Anaphylaktische Reaktion auf Humaninsulin: Erfolgreiche Hyposensibilisierung

Wintermantel, C; Fischer, Nina; Müller, Philip C.; Hg, Velcovsky; Lischka, G; Eggstein, M.

doi:10.1055/s-2008-1067783

Cited by 4 publications

(1 citation statement)

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“…These cases present interesting and unique aspects because insulin allergy in gestational diabetes is extremely infrequent owing to its immunosuppressive state [ 2 ]. To our knowledge, less than 10 cases of allergy to insulin in gestational diabetes have been reported globally [ 15 16 17 18 19 20 21 22 ] and this is the first report of insulin allergy in gestational diabetes in Korea. Therefore, we report two cases of allergic reaction to insulin in patients with gestational diabetes and a review of the literature.…”

Section: Discussionmentioning

confidence: 99%

Two Cases of Allergy to Insulin in Gestational Diabetes

Kim

et al. 2015

Endocrinol Metab

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Allergic reaction to insulin is uncommon since the introduction of human recombinant insulin preparations and is more rare in pregnant than non-pregnant females due to altered immune reaction during pregnancy. Herein, we report two cases of allergic reaction to insulin in gestational diabetes that were successfully managed. One case was a 33-year-old female using isophane-neutral protamine Hagedorn human insulin and insulin lispro. She experienced dyspnea, cough, urticaria and itching sensation at the sites of insulin injection immediately after insulin administration. We discontinued insulin therapy and started oral hypoglycemic agents with metformin and glibenclamide. The other case was a 32-year-old female using insulin lispro and insulin detemer. She experienced pruritus and burning sensation and multiple nodules at the sites of insulin injection. We changed the insulin from insulin lispro to insulin aspart. Assessments including immunoglobulin E (IgE), IgG, eosinophil, insulin antibody level and skin biopsy were performed. In the two cases, the symptoms were resolved after changing the insulin to oral agents or other insulin preparations. We report two cases of allergic reaction to human insulin in gestational diabetes due to its rarity.

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