Anaphylaxie

Przybilla, Bernhard; Ring, Johannes; Ruëff, Franziska

doi:10.1007/s00105-007-1434-6

Cited by 10 publications

(3 citation statements)

References 26 publications

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“…Asthmatic reactions have been attributed to reflex activation of the parasympathetic system by the irritating effect of sulfites, possibly enhanced by a deficiency of sulfite oxidase. Besides this pseudoallergic mechanism, in at least some cases of sulfite hypersensitity, an immunoglobulin E (IgE)-mediated immediatetype allergic reaction must be considered (95). Sulfites may be contained in wine, but they are also contained in foods that are poor in histamine, such as fruit juice, frozen vegetables, and lettuce.…”

Section: Histamine and Foodmentioning

confidence: 99%

Histamine and histamine intolerance

Maintz

Novak

2007

The American Journal of Clinical Nutrition

710

665

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Histamine intolerance results from a disequilibrium of accumulated histamine and the capacity for histamine degradation. Histamine is a biogenic amine that occurs to various degrees in many foods. In healthy persons, dietary histamine can be rapidly detoxified by amine oxidases, whereas persons with low amine oxidase activity are at risk of histamine toxicity. Diamine oxidase (DAO) is the main enzyme for the metabolism of ingested histamine. It has been proposed that DAO, when functioning as a secretory protein, may be responsible for scavenging extracellular histamine after mediator release. Conversely, histamine N-methyltransferase, the other important enzyme inactivating histamine, is a cytosolic protein that can convert histamine only in the intracellular space of cells. An impaired histamine degradation based on reduced DAO activity and the resulting histamine excess may cause numerous symptoms mimicking an allergic reaction. The ingestion of histamine-rich food or of alcohol or drugs that release histamine or block DAO may provoke diarrhea, headache, rhinoconjunctival symptoms, asthma, hypotension, arrhythmia, urticaria, pruritus, flushing, and other conditions in patients with histamine intolerance. Symptoms can be reduced by a histamine-free diet or be eliminated by antihistamines. However, because of the multifaceted nature of the symptoms, the existence of histamine intolerance has been underestimated, and further studies based on double-blind, placebo-controlled provocations are needed. In patients in whom the abovementioned symptoms are triggered by the corresponding substances and who have a negative diagnosis of allergy or internal disorders, histamine intolerance should be considered as an underlying pathomechanism.

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Section: Histamine and Foodmentioning

confidence: 99%

Histamine and histamine intolerance

Maintz

Novak

2007

The American Journal of Clinical Nutrition

710

665

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“…Systemic anaphylaxis is generally recognized as a severe allergic reaction caused by IgE-mediated activation of mast cells, leading to a massive release of vasoactive mediators that induce acute hypotension and shock. The worst manifestations are cardiovascular collapse, bronchospasm and laryngeal oedema [3,4]. The diagnosis of anaphylaxis is based primarily on clinical criteria and is valid even if the results of laboratory tests, such as serum total tryptase levels [5], are within normal limits.…”

Section: Introductionmentioning

confidence: 99%

The awareness of anaphylaxis reaction to local anesthesia in Dentistry

Eskandari¹,

Nekourad²,

Bastan³

2014

J Allergy Asthma

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Background: Anaphylaxis is one of the rare clinical events specifically related to anesthesia leading to morbidity and mortality. In this manner, the aim of our study was to determine knowledge of Iranian dentists about symptom, sign and management of anaphylaxis to local anesthesia. Methods: The study was designed with a questionnaire (16 questions) related to anaphylaxis to local anesthesia in Iran. The dentists working in their private office and clinic of medical dentist randomly selected and asked to complete questionnaire. Results: 72% of dentists accepted to take part in the study. Although all attendants knew one or more symptoms and signs of anaphylaxis but none of them marked all options related to anaphylaxis. In relation to, about 72.9% of dentists knew epinephrine as the first choice in the treatment of anaphylaxis shock, but only 20% of them had kept emergency equipments and facilities such as drugs in their offices to treat shock. This study showed that less than 10% of the dentists were aware of the recommended dose of epinephrine to use in adults or children. Conclusion: Our study concludes that some of dentists are not aware of this emergency vital clinical condition. Therefore, dentists should be developed their knowledge on the subject of the causes and treatment of anaphylaxis shock alternatively with attendance in related courses which holding by academic centers.

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“…Sodium metabisulfite (Na 2 S 2 O 5 ) is commonly used as a preservative in a variety of food products, wine, and drugs due to its antimicrobial and antioxidant properties [1]. In the process of wine production, it can inhibit the growth of bacteria, control the activities of fermentation microorganisms, and delay the start time of fermentation.…”

Section: Introductionmentioning

confidence: 99%

Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response

Jin

Zhao

Zhou

et al. 2021

Cells

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Sodium metabisulfite (Na2S2O5) is widely used as a preservative in the food and wine industry. However, it causes varying degrees of cellular damage to organisms. In order to improve our knowledge regarding its cyto-toxicity, a genome-wide screen using the yeast single deletion collection was performed. Additionally, a total of 162 Na2S2O5-sensitive strains and 16 Na2S2O5-tolerant strains were identified. Among the 162 Na2S2O5 tolerance-related genes, the retromer complex was the top enriched cellular component. Further analysis demonstrated that retromer complex deletion leads to increased sensitivity to Na2S2O5, and that Na2S2O5 can induce mislocalization of retromer complex proteins. Notably, phosphatidylinositol 3-monophosphate kinase (PI3K) complex II, which is important for retromer recruitment to the endosome, might be a potential regulator mediating retromer localization and the yeast Na2S2O5 tolerance response. Na2S2O5 can decrease the protein expressions of Vps34, which is the component of PI3K complex. Therefore, Na2S2O5-mediated retromer redistribution might be caused by the effects of decreased Vps34 expression levels. Moreover, both pharmaceutical inhibition of Vps34 functions and deletions of PI3K complex II-related genes affect cell tolerance to Na2S2O5. The results of our study provide a global picture of cellular components required for Na2S2O5 tolerance and advance our understanding concerning Na2S2O5-induced cytotoxicity effects.

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Anaphylaxie

Cited by 10 publications

References 26 publications

Histamine and histamine intolerance

Histamine and histamine intolerance

The awareness of anaphylaxis reaction to local anesthesia in Dentistry

Retromer Complex and PI3K Complex II-Related Genes Mediate the Yeast (Saccharomyces cerevisiae) Sodium Metabisulfite Resistance Response

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