Anaphylaxis after Treatment with an Endodontic Material Containing Polyethylene Glycol

Alnæs, Marie; Storaas, Torgeir; Vindenes, Hilde Kristin; Guttormsen, Anne Berit; Björkman, Lars

doi:10.1016/j.joen.2024.09.002

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Cited by 2 publications

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Insights Into the November 2024 Issue of the Journal of Endodontics

Aminoshariae,

Azarpazhooh,

Fouad

et al. 2024

Journal of Endodontics

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Insights Into the November 2024 Issue of the Journal of Endodontics

Aminoshariae,

Azarpazhooh,

Fouad

et al. 2024

Journal of Endodontics

View full text Add to dashboard Cite

Physicochemical properties and biological interaction of calcium silicate-based sealers - in vivo model

Janini,

Moraes,

Pelepenko

et al. 2024

Preprint

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Objectives: To investigate volumetric changes, in vivo biocompatibility, and systemic migration from eight commercial materials in paste/paste, powder/liquid, and pre-mixed forms. Material and Methods: After characterisation, tubes were implanted in Wistar rats’ alveolar bone and subcutaneous tissues. Micro-CT evaluated volumetric changes pre/post 30 days of implantation. Histological and immunohistochemistry analyses assessed biocompatibility. Kidney samples underwent spectrometry (ICP-MS) for tantalum, tungsten and zirconium. Statistical analysis determined normality and significance (p < 0.05). Results: Characterisation revealed calcium, silicon, and radiopacifiers in the materials. Volumetric changes showed greater alteration in subcutaneous tissues than alveolar bone; BioRoot RCS and MTApex (powder/liquid) were most stable. Histological analysis indicated intense inflammation for AH Plus Jet, moderate for others; IL-10 was marked positively for all materials. Unexpectedly, AH Plus Jet had an 18-fold higher tungsten and a 37-fold higher zirconium mass fraction in kidneys versus controls, while tantalum showed lower accumulation patterns. Conclusion: Root canal filling materials’ responses varied by implantation site and form, demonstrating acceptable biocompatibility. Tantalum and zirconium oxide radiopacifiers appear systemically safe; tungsten-based radiopacifiers are unsuitable due to metal accumulation risks. Clinical Relevance: This study highlights the need for further in vivo studies on endodontic sealers’ chemical, biological, and physical behaviors and their systemic migration.

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Anaphylaxis after Treatment with an Endodontic Material Containing Polyethylene Glycol

Cited by 2 publications

References 17 publications

Insights Into the November 2024 Issue of the Journal of Endodontics

Insights Into the November 2024 Issue of the Journal of Endodontics

Physicochemical properties and biological interaction of calcium silicate-based sealers - in vivo model

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