Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature

Ha, Sang Ook; Kim, Dae Yong; Sohn, Chang Hwan; Lim, Kyoung Soo

doi:10.1007/s11739-013-1019-6

Cited by 65 publications

(59 citation statements)

References 21 publications

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“…For example, FITC could be immunogenic in humans (44), thereby limiting use of mAbCAR targeting for clinical translation. If so, antibody-tagging systems (e.g., nanocapsules, DNA bridges, Fc-tagging sequences) that proved to be safe in different clinical applications could be adapted for overcoming this possible limitation.…”

Section: Discussionmentioning

confidence: 99%

T cells expressing chimeric antigen receptor promote immune tolerance

Pierini¹,

Iliopoulou²,

Peiris³

et al. 2017

JCI Insight

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Section: Discussionmentioning

confidence: 99%

T cells expressing chimeric antigen receptor promote immune tolerance

Pierini¹,

Iliopoulou²,

Peiris³

et al. 2017

JCI Insight

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“…26 31 In fact, it is the only examination that can confirm the mere existence of a CNV, and is also used to evaluate the location and extent of classic and occult forms, particularly when it is coupled with indocyanine green angiography (ICGA). In addition to the location and the area of leakage, FA provides information about the dynamic exudative activity of the lesion.…”

Section: Introductionmentioning

confidence: 99%

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)

Schmidt‐Erfurth

Chong

Loewenstein³

et al. 2014

Br J Ophthalmol

528

456

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Age-related macular degeneration (AMD) is still referred to as the leading cause of severe and irreversible visual loss world-wide. The disease has a profound effect on quality of life of affected individuals and represents a major socioeconomic challenge for societies due to the exponential increase in life expectancy and environmental risks. Advances in medical research have identified vascular endothelial growth factor (VEGF) as an important pathophysiological player in neovascular AMD and intraocular inhibition of VEGF as one of the most efficient therapies in medicine. The wide introduction of anti-VEGF therapy has led to an overwhelming improvement in the prognosis of patients affected by neovascular AMD, allowing recovery and maintenance of visual function in the vast majority of patients. However, the therapeutic benefit is accompanied by significant economic investments, unresolved medicolegal debates about the use of off-label substances and overwhelming problems in large population management. The burden of disease has turned into a burden of care with a dissociation of scientific advances and real-world clinical performance. Simultaneously, ground-breaking innovations in diagnostic technologies, such as optical coherence tomography, allows unprecedented high-resolution visualisation of disease morphology and provides a promising horizon for early disease detection and efficient therapeutic follow-up. However, definite conclusions from morphologic parameters are still lacking, and valid biomarkers have yet to be identified to provide a practical base for disease management. The European Society of Retina Specialists offers expert guidance for diagnostic and therapeutic management of neovascular AMD supporting healthcare givers and doctors in providing the best state-of-the-art care to their patients.Trial registration numberNCT01318941.

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“…In addition, these modalities are invasive involving the use of intravenous contrast that can result in systemic side effects and rarely anaphylaxis. 4–6 …”

Section: Introductionmentioning

confidence: 99%

Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography

Novais

Adhi

Moult

et al. 2016

American Journal of Ophthalmology

141

111

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Purpose To compare visualization of choroidal neovascularization (CNV) secondary to age-related macular degeneration (AMD) using an ultra-high speed swept-source (SS)-optical coherence tomography angiography (OCTA) prototype versus a spectral-domain (SD)-OCTA device. Design Comparative analysis of diagnostic instruments. Methods Patients were prospectively recruited to be imaged on SD-OCT and SS-OCT devices on the same day. The SD-OCT device employed is the RTVue Avanti that operates at ~840nm wavelength and 70,000 A-scans/second. The SS-OCT device used is an ultra-high speed long-wavelength prototype that operates at ~1050nm wavelength and 400,000 A-scans/second. Two observers independently measured the CNV area on OCTA en face images from the two devices using ImageJ. The non-parametric Wilcoxon signed-rank test was used to compare area measurements and p-values of <0.05 were considered statistically significant. Results Fourteen eyes from 13 patients were enrolled. The CNV in 11 eyes (78.6%) were classified as type-1, 2 eyes (14.3%) as type-2, and 1 eye (7.1%) as mixed type. Total CNV area measured using SS-OCT and SD-OCT 3mm × 3mm OCTA were 0.949 ± 1.168mm2 and 0.340 ± 0.301mm2, respectively (p=0.001). For the 6mm × 6mm OCTA the total CNV area using SS-OCT and SD-OCT were 1.218 ± 1.284mm2 and 0.604 ± 0.597mm2, respectively (p=0.0019). The field of view did not significantly affect the measured CNV area (p=0.19 and p=0.18 for SS-OCT and SD-OCT respectively). Conclusion SS-OCTA yielded significantly larger CNV areas than SD-OCTA. It is possible that SS-OCTA is better able to demarcate the full extent of CNV vasculature.

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Anaphylaxis caused by intravenous fluorescein: clinical characteristics and review of literature

Cited by 65 publications

References 21 publications

T cells expressing chimeric antigen receptor promote immune tolerance

T cells expressing chimeric antigen receptor promote immune tolerance

Guidelines for the management of neovascular age-related macular degeneration by the European Society of Retina Specialists (EURETINA)

Choroidal Neovascularization Analyzed on Ultrahigh-Speed Swept-Source Optical Coherence Tomography Angiography Compared to Spectral-Domain Optical Coherence Tomography Angiography

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