Anaphylaxis Induced by Conlinin, a 2S Storage Protein in Flaxseed

Abstract

Palabras clave: Alergia a semillas de lino. Diagnóstico por componentes. Alergia a alimentos. Anafilaxia.The prevalence of allergy to seeds is highly influenced by the geographical area and eating habits. In Spain, according to data from Alergologica 2015 [1], allergy to tree nuts and seeds accounts for 28.4% of all cases of food allergy.Flaxseed is the seed of the plant Linum usitatissimum. It is consumed as a nutritional supplement because it is rich in dietary fiber, polyunsaturated fatty acids, and lignans.Flaxseed has rarely been reported to be a sensitizer [2], and there are few reports of anaphylaxis caused by flaxseed in the literature [3][4][5][6]. However, it is an increasingly common source of allergens as a result of its use in diets for its nutritional benefits and anticancer properties.Flaxseed contains many potential allergens. The storage protein content ranges from 10% to 37%, and has been reported to be as high as 20%-42% for conlinin (the low-molecularmass fraction [2S]) and 58%-66% for linin (the major protein fraction [12S]) [7]. A 56-kDa IgE-binding protein reported in 1 case [5] is thought to correspond to malate dehydrogenase-1. Other authors have recently suggested that the lipid transfer protein (LTP) was the relevant allergen in a case of flaxseed anaphylaxis [8].We present 2 cases of flaxseed-induced anaphylaxis. Patient 1 was a 46-year-old white woman with a personal history of bronchial asthma and rhinoconjunctivitis who presented with pharyngeal pruritus, lingual and palpebral angioedema, dyspnea, and profuse diarrhea immediately after eating multicereal biscuits (oat, rice, flaxseeds, egg, almonds, and raisins). Patient 2 was a 64-year-old white woman with a personal history of breast cancer, allergy to ceftriaxone, and allergic rhinoconjunctivitis due to pollens and pet dander. She presented palmoplantar itching, generalized urticaria, lip angioedema, and throat tightness immediately after eating a

Effect of flax seeds on lipids: Insulin and ghrelin in type 2 diabetic women with metabolic syndrome

“…Flaxseed is therefore considered to be of negligible risk [14]. Allergy to flax is rare [15]. there are very few case reports of anaphylaxis caused by flax since 1930 [16].…”

New arrivals in anaphylaxis to foods

“…Flaxseed (linseed) was originally utilised for its oil and was also a principal component of birdseed but is now consumed as a food and for medicinal/ health purposes. Whilst earlier case reports involved individuals sensitised to flaxseed probably through handling of birdseed [64], more recent cases report reactions to flaxseed in foods [65][66][67]. Most recently, a case of a nonatopic male who had four episodes of unexplained anaphylaxis, found that the last episode was linked to the consumption of a flaxseed product [68 & ].…”