Anaphylaxis to both Decamethonium and Suxamethonium

Fisher, M. McD.; Chan, M. C. Y.

doi:10.1177/0310057x8201000213

Cited by 9 publications

(2 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In five other patients we have investigated who reacted to suxamethonium, five showed positive skin tests to suxamethonium and decamethonium, and originally we concluded that for subject 14 an error had been made on the first skin test. 9 Five years later, intradermal tests and the RIA were positive, and on a subsequent occasion two years later, the intradermal test for suxamethonium was negative while the RIA remained positive.…”

Section: Groupmentioning

confidence: 94%

See 1 more Smart Citation

Persistence of Allergy to Anaesthetic Drugs

Fisher

Baldo

1992

Anaesth Intensive Care

View full text Add to dashboard Cite

Intradermal testing and RIA testing for specific IgE antibodies to neuromuscular blocking drugs (NMBDs) were performed in patients referred to an Anaesthetic Allergy Clinic. Six patients were initially investigated four to 29 years after clinical anaphylaxis during anaesthesia and two of these patients and sixteen others were investigated by intradermal testing on two occasions at least four years apart. Seven patients had RIA tests for NMBD-specific IgE antibodies on two occasions at the time of skin testing. In all but two patients the evidence for drug-specific antibodies persisted 4-29 years after the reactions. In one patient all tests became negative and in another the skin test became negative but the positive RIA persisted. Evidence of antibodies to NMBDs persisted in 21 of 22 patientswho had had anaphylactic reactions to these drugs during anaesthesia. In the absence of evidence of allergy diminishing with time in the majority of patients it would seem wise to avoid drugs responsible for reactions for the rest of the patient's life.

show abstract

Section: Groupmentioning

confidence: 94%

“…One patient (Case 14) who has been described in detail 9 is worthy of individual mention. This patient initially reacted to decamethonium and one month later was skin test positive to decamethonium and skin test negative to suxamethonium, and had IgE serum antibodies to suxamethonium detected by RIA.…”

Section: Groupmentioning

confidence: 99%