Anaphylaxis to food additives

Treudler, Regina; Simon, Jan C.

doi:10.1007/s40629-022-00203-y

Cited by 7 publications

(3 citation statements)

References 25 publications

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“…Guar gum (E412) was found in one toothpaste label, and arabic gum (E414) was an excipient in five of the surveyed chewing gums. Its use has been associated with the triggering of several clinical symptoms that, although generally rare, may include serious reactions, including anaphylactic reactions 27 .…”

Section: Resultsmentioning

confidence: 99%

Food allergens in oral care products

Coimbra

Costa

Evangelista

et al. 2023

Sci Rep

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Food allergies are a growing concern, especially in Western societies and can dramatically impact the quality of life of affected individuals. In recent years, various food allergens have been introduced into the oral care industry to improve product properties and provide the best possible treatment. Since small doses of food allergens may be sufficient to trigger allergic reactions, the non-discrimination of the sources of certain excipients in the product composition can compromise the patient's health. Therefore, knowledge and awareness of allergies and product composition among health professionals are critical on behalf of patients’ and consumers’ health. This study aimed to ascertain the presence of dairy products (e.g., cow's milk proteins and lactose), cereals (e.g., gluten, soy, and oats), fruits, nuts, spices, shellfish, and additives as excipients in oral care products for outpatients and products for professional use in the Dental Office. Among the 387 surveyed products, the highest prevalence of food allergens was found in toothpaste, fluoride varnishes, and alginates, mostly in spices and fresh fruits. As food allergies may occur because of erroneous information or a lack of labeling on the allergen list, manufacturers should be more rigorous in declaring allergens on product labeling regarding the safety of consumers.

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Section: Resultsmentioning

confidence: 99%

Food allergens in oral care products

Coimbra

Costa

Evangelista

et al. 2023

Sci Rep

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“…Patent blue V is a synthetic triarylmethane dye used primarily in the food industry, so that sensitization is also possible via food intake [ 2 ]. In pharmaceuticals, it may be added to laxatives or cold remedies, for example, or used as a pure substance to mark sentinel lymph nodes or varicoceles.…”

Section: Patent Blue V (E 131)mentioning

confidence: 99%

Anaphylaxis to drug excipients

Pfützner

2022

Allergo J Int

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SummaryIn addition to the therapeutic agent, drugs contain excipients such as stabilizers, preservatives, solubilizers, or dyes, some of which are identical to additives in foods. Anaphylaxis to these excipients is probably an underestimated problem. After the first descriptions of anaphylactic reactions to drug excipients appeared more than 30 years ago, the number of corresponding reports has increased significantly over the years. However, a diagnostic gap exists in the clarification of drug allergic reactions when the index product is not known and/or is not available for testing. In the present work, individual excipients are presented as examples for which publications on anaphylaxis are available. Furthermore, the options of allergological testing both in vivo and in vitro are discussed. The pathogenesis of such reactions is still unresolved in many cases, and current concepts are briefly presented in the conclusion. With increasing knowledge about anaphylaxis to drug excipients, it is assumed that these can then be recognized more often and diagnostically clarified.

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“…Patentblau V ist ein synthetischer Triarylmethan-Farbstoff, der in erster Linie in der Nahrungsmittelindustrie Verwendung findet, sodass Sensibilisierungen auch über Nahrungsmittelaufnahme möglich sind [ 2 ]. In Arzneimitteln kann er beispielsweise Laxativa oder Erkältungsmitteln beigemischt sein oder als Reinsubstanz zur Markierung von Schildwächterlymphknoten oder Varikozelen eingesetzt werden.…”

Section: Patentblau V (E 131)unclassified

Anaphylaxie auf Hilfsstoffe in Arzneimitteln

Pfützner¹

2022

Allergo J

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Neben dem therapeutischen Agens enthalten Arzneimittel Hilfsstoffe als beispielsweise Stabilisatoren, Konservierungsstoffe, Löslichkeitsvermittler oder Farbstoffe, die teilweise identisch mit Zusatzstoffen in Nahrungsmitteln sind. Anaphylaxien auf diese Hilfsstoffe sind ein vermutlich unterschätztes Problem. Nachdem erste Beschreibungen anaphylaktischer Reaktionen auf Arzneimittelhilfsstoffe bereits vor über 30 Jahren auftauchten, hat die Zahl entsprechender Berichte in den letzten Jahren deutlich zugenommen. Eine diagnostische Lücke besteht allerdings in der Abklärung arzneimittelallergischer Reaktionen, wenn das Indexpräparat nicht bekannt ist und/oder nicht als Originalpräparat für Testungen zur Verfügung steht. In der vorliegenden Arbeit werden einzelne Hilfsstoffe exemplarisch vorgestellt, für die Publikationen zu Anaphylaxien vorliegen. Des Weiteren werden die Optionen allergologischer Testungen sowohl in vivo als auch in vitro besprochen. Die Pathogenese derartiger Reaktionen ist vielfach noch unklar, hier werden abschließend aktuelle Konzepte kurz vorgestellt. Mit zunehmendem Wissen über Anaphylaxien auf Arzneimittelhilfsstoffe ist davon auszugehen, dass diese auch vermehrt wahrgenommen und diagnostisch aufgeklärt werden können. Zitierweise: Pfützner W. Anaphylaxis to drug excipients. Allergo J Int 2022;31:137-40 https://doi.org/10.1007/s40629-022-00214-9

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Anaphylaxis to food additives

Cited by 7 publications

References 25 publications

Food allergens in oral care products

Food allergens in oral care products

Anaphylaxis to drug excipients

Anaphylaxie auf Hilfsstoffe in Arzneimitteln

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