Anaphylaxis to olive fruit due to lipoprotein sensitization

Olive juice dry extract containing hydroxytyrosol, as a nontoxic and safe substance: Results from pre-clinical studies and review of toxicological studies

“…Results showed that the young men consuming extra virgin olive oil (doses not reported, but stated as containing sterols) for 3 weeks, had a statistically significant increase in serum testosterone and luteinizing hormone levels [66] . These effects are considered as a positive action on the androgen hormonal profile of men [75] and cannot be only attributed to phenolics compounds due to the additional presence sterols in the product used in this study [70] .…”

“…However, food allergy due to olive fruit is a rare pathology described in the literature, despite widespread consumption [75] . Nevertheless, sporadic case reports of olive food allergy have been identified [71] .…”

Allergens Responsible for Anaphylaxis After Olive Fruit Ingestion

“…Ole e 13 is a thaumatin-like protein of 21 kDa, which has been described to be responsible for job-related respiratory allergy in an olive oil mill worker who does not experience allergic symptoms after ingestion of edible olives [9]. Some authors have related allergy to olive ingestion with lipophilic proteins, however in our case the IgE reactive proteins are hydrophilic [4].…”

“…Olive fruit is widely consumed as food and it is also used as crude material to obtain olive oil. In spite of its common intake, cases of allergy to olive fruit have been seldomly reported [1][2][3][4]. Some olive fruit allergens have been identified as the thaumatin-like protein Ole e 13, which is responsible of occupational allergy in olive oil mill workers [5].…”

“…After olive ingestion anaphylaxis [2,3] and urticaria [4] have been described in the literature. Skin prick test and specific IgE have been used for diagnosis.…”