Anaphylaxis to scorpion antivenin and its management following envenomation by Indian red scorpion, <i>Mesobuthus tamulus</i>

Bhoite, R. R.; Bhoite, Girija Ramesh; Bagdure, Dayanand; Bawaskar, Himmatrao Saluba

doi:10.4103/0972-5229.164807

Cited by 4 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Pacientes com história prévia de reações de hipersensibilidade ao soro equino e pacientes com doenças atópicas, principalmente asma grave, apresentam um maior risco de desenvolverem reações anafiláticas ao tratamento com SAEsc, por isso, devem de ser administrados apenas em casos de envenenamento sistêmico, em que o benefício do soro é prevalente. Ademais, não existem contraindicações absolutas ao tratamento com soro antiescorpiônico (BHOITE et al, 2015).…”

Section: Discussão Soro Antiescorpiônicounclassified

“…Os sinais e sintomas de reações de hipersensibilidade vão de apresentações cutâneas, como prurido, rubor, edema e urticária, até reações sistêmicas mais graves, como broncoespasmos, dificuldade respiratória, edema de glote, hipotensão e arritmias. No entanto, as reações de hipersensibilidade podem estar mascaradas pelas altas concentrações de catecolaminas decorrente do envenenamento pelo escorpião (BHOITE et al, 2015;CUPO et al, 1991).…”

Section: Reações De Hipersensibilidadeunclassified

See 1 more Smart Citation

Soroterapia Antiescorpiônica E Reações De Hipersensibilidade Em Pacientes Com Envenenamento Por Escorpião

Ramalho,

Branco,

Franco

et al. 2024

REASE

View full text Add to dashboard Cite

No Brasil são registrados anualmente mais de 170 mil casos de acidente por picada de escorpião, com uma taxa de mortalidade de aproximadamente 0,15%, sendo mais comum na população pediátrica, no qual o choque cardiogênico e o edema agudo pulmonar são as principais causas de morte por escorpionismo. O tratamento compreende a abordagem sintomática, associado ao suporte e monitoramento de condições vitais dos pacientes, além de infusão intravenosa de soro antiveneno para escorpião, que depende da clínica e idade do paciente. Este estudo tem como objetivo apresentar as indicações de soroterapia antiescorpiônica, além de relatar as reações imediatas de hipersensibilidade envolvendo o soro antiescorpiônico. O tratamento com o SAEsc é indicado em casos de escorpionismo moderado e grave. No entanto, reações de hipersensibilidade, como anafilaxia e doença do soro, podem ser observados. Mas estudos evidenciam que as altas concentrações de catecolaminas após envenenamento por escorpião protege os pacientes contra as reações anafiláticas imediatas do soro antiescorpiônico.

show abstract

Section: Discussão Soro Antiescorpiônicounclassified

Section: Reações De Hipersensibilidadeunclassified

Soroterapia Antiescorpiônica E Reações De Hipersensibilidade Em Pacientes Com Envenenamento Por Escorpião

Ramalho,

Branco,

Franco

et al. 2024

REASE

View full text Add to dashboard Cite

show abstract

Section: Clinical Take-home Messagementioning

confidence: 99%

“…Venom-induced and antivenom-induced anaphylaxis should be considered in these patients since some symptoms of anaphylaxis can overlap with symptoms of severe systemic envenomation [126][127][128][129]. Furthermore, adrenergic storm in severe envenomations can mask the symptoms of anaphylaxis or even protect against it [126,130]. Cutaneous signs (generalized pruritus, urticaria, and rash), eosinophilic leukocytosis, and quick onset of symptoms (within minutes) are in favor of anaphylaxis [129].…”

Section: Clinical Take-home Messagementioning

confidence: 99%

Scorpion envenomation-associated myocarditis: A systematic review

et al. 2023

View full text Add to dashboard Cite

Background Scorpion envenomation is associated with several complications. One of the most serious complications is the cardiac involvement in the form of myocarditis that remains the main reason for mortalities associated with scorpion envenomation. The present review aims to elucidate clinical and paraclinical findings associated with scorpion-related myocarditis, and to explore different management strategies and subsequent outcomes. Methods We searched PubMed, Web of Science, Scopus, and Google Scholar for articles related to keywords of myocarditis associated with scorpion envenomation up to May 1, 2022. Each article was carefully reviewed by two independent researchers. In case of disagreement for inclusion, we sought a third researcher opinion. Results A total of 703 cases from 30 case reports and 34 case series were included in our review. Myocarditis associated with scorpion envenomation was usually reported in children presenting with cardiopulmonary symptoms including pulmonary edema (60.7%) and shock or hypotension (45.8%). The most common ECG findings are sinus tachycardia (82%) followed by ST-T changes (64.6%). The management typically included inotropes (especially dobutamine), prazosin, diuretics, nitroglycerine and digoxin, when indicated. Mechanical ventilation was required in 36.7% of the patients. Mortality in confirmed scorpion-related myocarditis cases is estimated at 7.3%. Almost all survived cases showed rapid recovery and improvement in the left ventricular function. Conclusion Even though myocarditis associated with scorpion envenomation is rare, it remains a serious and in some of cases a fatal consequence of scorpion sting. In case of relative presentations, particularly in envenomed children, diagnosis of myocarditis should be considered. Early screening using serial cardiac markers and echocardiography can guide the treatment. Prompt treatment that focuses on cardiogenic shock and pulmonary edema usually results in a favorable outcome.

show abstract

“…Devi et al (1970);Rahimtoola et al (1970);Gueron et al (1992);Sibley et al (1993);Bawaskar and Bawaskar, (1994); Reddy, (2013);Pandurang et al (2014);Bhoite et al (2015);Akella et al (2016);Junior et al (2019) …”

mentioning

confidence: 99%

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins

2021

View full text Add to dashboard Cite

The Indian red scorpion (Mesobuthus tamulus) is one of the world’s deadliest scorpions, with stings representing a life-threatening medical emergency. This species is distributed throughout the Indian sub-continent, including eastern Pakistan, eastern Nepal, and Sri Lanka. In India, Indian red scorpions are broadly distributed in western Maharashtra, Saurashtra, Kerala, Andhra Pradesh, Tamil Nadu, and Karnataka; however, fatal envenomations have been recorded primarily in the Konkan region of Maharashtra. The Indian red scorpion venom proteome comprises 110 proteins belonging to 13 venom protein families. The significant pharmacological activity is predominantly caused by the low molecular mass non-enzymatic Na+ and K+ ion channel toxins. Other minor toxins comprise 15.6% of the total venom proteome. Indian red scorpion stings induce the release of catecholamine, which leads to pathophysiological abnormalities in the victim. A strong correlation has been observed between venom proteome composition and local (swelling, redness, heat, and regional lymph node involvement) and systemic (tachycardia, mydriasis, hyperglycemia, hypertension, toxic myocarditis, cardiac failure, and pulmonary edema) manifestations. Immediate administration of antivenom is the preferred treatment for Indian red scorpion stings. However, scorpion-specific antivenoms have exhibited poor immunorecognition and neutralization of the low molecular mass toxins. The proteomic analysis also suggests that Indian red scorpion venom is a rich source of pharmacologically active molecules that may be envisaged as drug prototypes. The following review summarizes the progress made towards understanding the venom proteome of the Indian red scorpion and addresses the current understanding of the pathophysiology associated with its sting.

show abstract

Anaphylaxis to scorpion antivenin and its management following envenomation by Indian red scorpion, Mesobuthus tamulus

Cited by 4 publications

References 10 publications

Soroterapia Antiescorpiônica E Reações De Hipersensibilidade Em Pacientes Com Envenenamento Por Escorpião

Soroterapia Antiescorpiônica E Reações De Hipersensibilidade Em Pacientes Com Envenenamento Por Escorpião

Scorpion envenomation-associated myocarditis: A systematic review

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins

Contact Info

Product

Resources

About