Anaphylaxis to sunflower seed

Noyes, J.H.; Boyd, George K.; Settipane, Guy A.

doi:10.1016/0091-6749(79)90107-6

Cited by 39 publications

(30 citation statements)

References 11 publications

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“…Sunflower seed products are used extensively as consumable commodities in margarine, and cooking and salad oils for humans, as well as for poultry [1]. In spite of their popularity, sunflower seeds have been reported to cause anaphylactic reactions after ingestion [2, 3, 4]and rhinitis and asthmatic reactions after occupational exposure to sunflower seed dust [5]. The identity of sunflower seed allergens is unknown.…”

Section: Introductionmentioning

confidence: 99%

Identification of Sunflower Seed IgE-Binding Proteins

Kelly¹,

Hlywka²,

Hefle³

2000

Int Arch Allergy Immunol

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Background: Sunflower seed can cause severe anaphylactic reactions in some susceptible individuals. It is conceivable that the 2S sunflower seed protein is an allergen based on its high degree of homology (34%) with the allergenic mature 2S albumin protein of the Brazil nut. The first step in determining the allergenicity of sunflower seed proteins is to identify IgE-binding proteins. Methods: Sera from sunflower seed-sensitive individuals were evaluated by radioallergosorbent test (RAST), isoelectric focusing (IEF) and sodium dodecyl sulfate-polyacrylamide gel electrophoresis immunoblotting with sunflower seed proteins. Results: Positive RAST scores (>2) were observed in 3 individuals and immunoblotting demonstrated IgE-binding to 2–7 distinct proteins ranging in size from 10 to 50 kD. Two out of 3 sera recognized two proteins between 16 and 17 kD. The lower molecular weight protein (16 kD) approximates to the prepo region of the precursor methionine-rich 2S albumin protein found in sunflower seed (SFA-8/SSA). IEF followed by immunoblotting demonstrated several IgE-binding proteins, including two proteins with isoelectric points of 5.97 and 5.3, respectively, which are consistent with the mature and immature forms of the SFA-8/SSA region. Conclusions: Sunflower seed contains several IgE-binding proteins, including regions of the high-methionine 2S albumin SFA-8/SSA.

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Section: Introductionmentioning

confidence: 99%

Identification of Sunflower Seed IgE-Binding Proteins

Kelly¹,

Hlywka²,

Hefle³

2000

Int Arch Allergy Immunol

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“…Sunflower seeds are commonly used as bird feed, and in some cases, the first reaction following ingestion was preceded by sensitization through handling, reflecting a role by skin contact or inhalation (12,13,15). Hypersensitivity after consuming the sunflower seed for the first time was reported in two children with atopic dermatitis (17,23) with one case sensitization apparently occurred by contact with impaired skin barrier (23).…”

Section: Anaphylaxis and Other Ige-mediated Reactions By Ingestionmentioning

confidence: 99%

“…Scattered case reports suggest that allergy to sunflower seed is not as common (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23). Sunflower seeds are commonly used as bird feed, and in some cases, the first reaction following ingestion was preceded by sensitization through handling, reflecting a role by skin contact or inhalation (12,13,15).…”

Section: Anaphylaxis and Other Ige-mediated Reactions By Ingestionmentioning

confidence: 99%

Hypersensitivities to sesame and other common edible seeds

Patel

Bahna

2016

Allergy

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Several seeds have been increasingly incorporated in various food items, with consequent risk of hypersensitivity reactions that are often severe. Identification of the specific seed as the culprit is often not explored or is difficult to verify. In this article, we reviewed the English literature from January 1930 to March 2016 using PubMed and Google Scholar searching for publications relevant to hypersensitivity to common edible seeds, namely sesame, sunflower seed, poppy seed, pumpkin seed, flaxseed, and mustard seed. Considering the worldwide consumption of those seeds, the number of published articles on the subject was relatively small and was mainly as case reports rather than large series. Allergy to sesame was more reported than to other seeds, with an estimated prevalence of 0.1-0.2%. In this review, we summarize the information relevant to each of the six seeds and their oils regarding the manifestations, routes of exposure, identified major allergens, and cross-reactivity with other seeds or other foods. We also addressed the important role of a thorough history taking in suspecting seed allergy, the limited reliability of routine diagnostic procedures, and the importance of verification by appropriate challenge tests. At present, management is basically dietary avoidance and the use of symptomatic medications that may include epinephrine auto-injectors. We did not encounter any well-designed studies on immunotherapy for seed allergy, but it is hoped that such a gap be filled by the development of safe effective protocols in the near future.With the growing trend of incorporating seeds in diet, hypersensitivity reactions have been increasingly occurring but are rarely suspected. The problem is compounded by the difficulty in identifying the culprit and the apparent underreporting. MethodsIn this article, we review the English literature from January 1930 to March 2016 using PubMed and Google Scholar. Special attention was directed to hypersensitivity reactions to commonly consumed seeds, namely sesame, sunflower, poppy, flaxseed, and pumpkin seed, and their respective oils. We also summarize the studies on the identified allergens and the cross-reactivities among these seeds and with other foods.

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“…Several reports have been published on sensitization and allergy to sunflower seeds (Noyes et al 1979;Axelsson et al 1994) and sensitivity seems to be provoked by birch or mugwort pollen (Vieths et al 2002). Sunflower seed lipid transfer protein has been identified as an allergen (Yagami 2010), while profilin in this species has been shown to be non-allergenic (Asturias et al 1998).…”

Section: Pistachios and Cashewsmentioning

confidence: 99%

An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens

Fisher¹,

Nawrocki²

2015

aliso

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Tree nut allergies are some of the most common and serious allergies in the United States. Patients who are sensitive to nuts or to seeds commonly called nuts are advised to avoid consuming a variety of different species, even though these may be distantly related in terms of their evolutionary history. This is because studies in the literature report that patients often display sensitivity to multiple nut species (crosssensitivity) if they have an existing nut allergy. These reports suggest that cross-sensitivity in patients with nut allergies may be caused by an IgE antibody reacting with epitopes present in the seed proteins of different species (cross-reactivity), for example, if IgE isolated from the serum of a patient were able to bind to both almond and peanut allergens. We hypothesize that allergenic proteins in seeds may have similar amino acid sequences that cause the observed cross-sensitivity. Here, we test the hypothesis that similarity in the protein sequences of allergenic nuts drives cross-sensitivity and cross-reactivity by reconstructing the gene trees of three allergenic seed-storage proteins (vicilin, legumin, and 2S albumin) from species sampled across vascular plants. We generate estimates of their phylogenetic relationships and compare these to the allergen cross-sensitivity and cross-reactivity data that is reported in the literature. In general, evolutionary relationships of the three proteins are congruent with the current understanding of plant species relationships. However, we find little evidence that distantly related nut species reported to be crossreactive share similar vicilin, legumin, or 2S albumin amino acid sequences. Our data thus suggests that features of the proteins other than their amino acid sequences may be driving the cross-reactivity observed during in vitro tests and skin tests. Our results support current treatment guidelines to limit nut and seed consumption if allergies are present in a patient. More studies are necessary to better understand the characteristics of allergenic proteins and patterns of cross-sensitivity in patients who suffer from nut allergies.

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Anaphylaxis to sunflower seed

Cited by 39 publications

References 11 publications

Identification of Sunflower Seed IgE-Binding Proteins

Identification of Sunflower Seed IgE-Binding Proteins

Hypersensitivities to sesame and other common edible seeds

An Evolutionary Perspective on Human Cross-sensitivity to Tree Nut and Seed Allergens

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