Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Vella, Joseph; Cracchiolo, Bernadette; Heller, Debra S.

doi:10.1016/j.jpag.2005.11.005

Cited by 4 publications

(1 citation statement)

References 19 publications

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“…Ovarian mucinous carcinoma with anaplastic carcinoma lesions in adolescent females has already been reported [20]. In the present study, we reported the first bilateral ovarian epithelial tumor, with one side borderline with intraepithelial carcinoma, which included mural anaplastic carcinoma nodules, and has not yet been reported at home and abroad, and it is worthy of record and standardized follow-up.…”

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confidence: 49%

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents

2022

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Bilateral ovarian epithelial neoplasms in adolescents are rare. Moreover, borderline mucinous neoplasms with local intraepithelial carcinoma with anaplastic carcinoma are even more infrequent. Herein, we presented a single case (a 17-year-old female) with regular menstrual cycles and stomach pain when eating who was diagnosed with a left ovarian tumor accompanied by mural nodules. The right ovarian cyst, the left ovary, and the fallopian tube were removed by surgery. Intraoperative diagnosis suggested a bilateral ovarian tumor with mural nodules, which include three different pathological types: sarcomatoid transformation, anaplastic carcinoma, and sarcoma. Paclitaxel combined with carboplatin was given for 6 cycles after an operation, and gonadotropin-releasing hormone agonist (GnRHa) was given at the beginning of chemotherapy for 3 cycles for ovarian function protection. Regular follow-up (the last follow-up was performed 48 months after the operation) of gynecological ultrasound and tumor indicators did not indicate recurrence. In clinical practice, it is necessary to pay attention to the symptoms such as abdominal pain in adolescent females. Routine non-invasive pelvic ultrasound is recommended to fully evaluate the nature of the tumor before surgery, and decide the operation mode. Also, intraoperative frozen pathology of the tissue should be performed as soon as possible.

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Section: Discussionsupporting

confidence: 49%

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents

2022

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Primary undifferentiated carcinoma of the small intestine: an immunohistochemical study and review of the literature

et al. 2010

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Primary undifferentiated carcinoma of the small intestine is an extremely rare neoplasm. Here, we report a case of primary undifferentiated carcinoma that arose from the ileum in a 65-year-old woman. Laboratory data revealed anemia and slightly elevated inflammatory parameters. Computed tomography showed a heterogeneous mass in the pelvic cavity, and magnetic resonance imaging revealed that the margin of the tumor mass was clear. Positron emission tomography using (18)F-fluoro-2-deoxy-D: -glucose (FDG) showed accumulation of FDG on the tumor mass with a standardized uptake value of 8.3. Partial resection of the ileum to remove the tumor was performed under a clinical diagnosis of small intestinal carcinoma. The tumor was nodulated and had a circumscribed margin 6.5 x 5.5 x 4 cm in diameter. Microscopically, the tumor was composed of giant polygonal cells with cellular atypia. Immunohistochemical examination revealed that the tumor cells expressed epithelial markers including AE1/AE3, CAM5.2, and EMA; however, lymphocytic, mesenchymal, and gastrointestinal stromal tumor markers were not expressed. We made a final diagnosis of primary undifferentiated carcinoma of the small intestine. The prognosis of patients with undifferentiated carcinoma of the small intestine is very poor. To improve the outcome of treatment, early and accurate diagnosis is essential, and additional therapy, including multimodality adjuvant therapy or the administration of novel molecular targeted drugs, should be considered.

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2006

Photomedicine and Laser Surgery

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Anaplastic Carcinoma Arising in an Ovarian Mucinous Cystadenocarcinoma in a 17-Year-Old Female

Cited by 4 publications

References 19 publications

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents

Ovarian mucinous borderline tumor with anaplastic carcinomatous nodules in adolescents

Primary undifferentiated carcinoma of the small intestine: an immunohistochemical study and review of the literature

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