Anaplastic large cell lymphoma, ALK-negative

Ferreri, Andrés J.M.; Govi, Silvia; Pileri, Stefano; Savage, Kerry J.

doi:10.1016/j.critrevonc.2012.06.004

Cited by 137 publications

(136 citation statements)

References 54 publications

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“…De estos casos CD3-, más del 90% presentaron un reordenamiento clonal de los receptores de linfocitos T (TCR) 16 . El CD4 es el marcador T que se conserva en la mayoría de los casos LACG ALK+ al comparar con otros marcadores T como CD2, CD3, CD5 y CD7, y también las células neoplásicas son positivas para CD45, CD45RO y CD25 19 . En nuestros casos utilizamos CD4, CD45RO y CD5 para corroborar la estirpe T de las lesiones.…”

Section: C B Aunclassified

“…El CD8 es usualmente negativo, pero hay informes de casos positivos. Algunos casos son positivos para CD68/KP1, pero no para CD68/PGM1, y la mayoría de los LACG ALK+ son negativos para BCL2 2,19 . Además, se ha informado de que estos linfomas pueden presentar inmunorreacción a marcadores mieloides como CD33 y CD13, y también a p63 2 .…”

Section: C B Aunclassified

“…Hay positividad para la clusterina en el 80-100% de los LACG, no así en los LACG primarios de piel 11 . Ni los LACG ALK+ ni los ALK-tienen inmunorreacción para el VEB, tanto por inmunohistoquímica (latent membrane protein-1 [LMP-1]) como por hibridación in situ y EBV-encoded small RNA (EBER) 19 . Los LACG ALK+ están asociados con una translocación cromosómica específica, la t(2;5)(p23;q35), con fusión del gen de cinasa, ALK, a un gen de la proteína nucleolar, NPM 1.…”

Section: C B Aunclassified

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Linfoma anaplásico de células grandes: estudio clínico-patológico e inmunohistoquímica de 20 casos clasificados de acuerdo a la revisión de la Organización Mundial de la Salud de neoplasias linfoides de 2016

Sevilla-Lizcano¹,

Ortíz-Hidalgo²

2022

GAMO

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Section: C B Aunclassified

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Linfoma anaplásico de células grandes: estudio clínico-patológico e inmunohistoquímica de 20 casos clasificados de acuerdo a la revisión de la Organización Mundial de la Salud de neoplasias linfoides de 2016

Sevilla-Lizcano¹,

Ortíz-Hidalgo²

2022

GAMO

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“…ALK-negative ALCL presents with lymph-node involvement in 70 % of cases, and extranodal spread is less common compared with ALK-positive ALCL [40]. The patients have an overall survival rate that lies between those of patients with PTCL, NOS and ALKpositive ALCL [36,41]. Because the distinction between PTCL, NOS, and ALK-negative ALCL is not always clearcut, ALK-negative ALCL was included in the WHO 2008 classification as a provisional entity; however, emerging evidence shows that it is distinct from PTCL, NOS.…”

Section: Alk-negative Alclmentioning

confidence: 99%

“…T-cell neoplasm that is not reproducibly distinguishable based on morphological features from ALKpositive ALCL, but lacks the ALK protein, according to the 2008 WHO classification [40]. In conjunction with strong and abundant CD30 expression in almost all cells, other features that favor this diagnosis are the absence of a B-cell program, as demonstrated by the lack of Pax5 expression (with the exception of cases with PAX5 gene amplification), loss of T-cell markers, expression of EMA, a cytotoxic phenotype, and lack of T-cell receptor (TCR) expression [41,42]. ALK-negative ALCL presents with lymph-node involvement in 70 % of cases, and extranodal spread is less common compared with ALK-positive ALCL [40].…”

Section: Alk-negative Alclmentioning

confidence: 99%

Peripheral T cell lymphoma in Asia

Park

2014

Int J Hematol

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Peripheral T-cell lymphomas (PTCLs) comprise a heterogeneous group of mature T-and NK-cell neoplasms, the incidence of which is higher in Asian countries than in Western countries. Although its etiology is mainly unknown, several risk factors (such as genetic factors, abnormal immunity, environmental factors, and infectious causes) have been proposed. PTCL are classified based on a combination of several parameters, including morphology, site of presentation, viral status, immunophenotype, and specific genetic alterations. Their classification is ongoing, with the emergence of new entities and refinement of existing entities because of the development of diagnostic markers and new genetic alterations. This review presents epidemiologic data for PTCL in Asia, together with recent progress in the pathology of PTCL compared with the WHO 2008 classification.Epidemiology T-and NK-cell lymphomas are uncommon: overall, they represent fewer than 25 % of all non-Hodgkin's lymphoma (NHL) [1][2][3]. The occurrence rates of various subtypes of T-and NK-cell lymphomas in Asia are significantly different from those observed in Western countries, and even among Asian countries. The incidence and distribution of T-and NK-cell lymphomas in several Asian countries is summarized in Fig. 1 and Table 1 [ [4][5][6][7][8][9][10][11][12][13][14][15].The frequencies of T-and NK-cell lymphomas seem to increase from West to East Asia. The occurrence rate of Tand NK-cell lymphomas are relatively low (\20 % of NHL) mainly in West Asia (Turkey 16.2 %, Iraq 19 %, and Kuwait 18 %) and South Asia (Pakistan 11.3 %, and India 20.2 %), but relatively high mainly in East Asia (China 32.5 %, Korea 22 %, and Japan 24.9 %) and Southeast Asia (Thailand 25 %). The proportion of T-and NK-cell lymphomas in Taiwan is very low (13.3 %) compared with that of other East Asian countries. Regarding the subtypes of T-and NK-cell lymphomas, two West (Turkey and Iraq) and one South (Pakistan) Asian countries share similar distribution patterns, presenting T lymphoblastic lymphoma (T-LBL) as the most common subtype, followed by peripheral T-cell lymphoma (PTCL) or anaplastic largecell lymphoma (ALCL). The frequency of mycosis fungoides/sezary syndrome (MF/SS) is very high in Kuwait. The distribution patterns of T-and NK-cell lymphomas in Thailand, Taiwan, and Korea are similar, whereas adult T-cell leukemia/lymphoma (ATLL) represents a high proportion of T-and NK-cell lymphomas in Japan. When ATLL is excluded, four countries (Thailand, Taiwan, Korea, and Japan) exhibit very similar patterns of subtype distribution of T-and NK-cell lymphomas. Extranodal NK/ T-cell lymphoma (ENKL) is frequent in China (48 %) and Korea (28.7 %), but is less frequent in Japan (10.4 %), as reported by a recent study performed by an international T-cell project [2]. In China, the frequency of T-or NK-cell lymphoma varies according to geographic region

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Flow Cytometry of Hematological Malignancies

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Anaplastic large cell lymphoma, ALK-negative

Cited by 137 publications

References 54 publications

Linfoma anaplásico de células grandes: estudio clínico-patológico e inmunohistoquímica de 20 casos clasificados de acuerdo a la revisión de la Organización Mundial de la Salud de neoplasias linfoides de 2016

Linfoma anaplásico de células grandes: estudio clínico-patológico e inmunohistoquímica de 20 casos clasificados de acuerdo a la revisión de la Organización Mundial de la Salud de neoplasias linfoides de 2016

Peripheral T cell lymphoma in Asia

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