Anaplastic large cell lymphoma presenting as an epiphyseal lytic lesion—a case report with clinico-pathologic correlation

Mounasamy, Varatharaj; Berns, Stephen; Azouz, E. Michel; Giusti, Vincent; Knapp, D. Raymond

doi:10.1007/s00256-006-0087-3

Cited by 9 publications

(4 citation statements)

References 12 publications

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“…ALCL represents about 10-15% of NHL in children [2]. It generally arises dominal or mediastinal lymph nodes; primary bone and CNS involvement is ver After a review of English literature, we identified 17 cases of pediatric prim ALCL (Table 2) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The median age of onset was 10 years and 82% (14/17) we Multifocal and unifocal bone lesions were identified in 7 (41%) and 10 (59%) respectively.…”

Section: Discussionmentioning

confidence: 99%

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Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

Restivo

Mussolin

D’Angelo

et al. 2021

Hemato

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Anaplastic large cell lymphoma (ALCL) is a histological subtype of non-Hodgkin lymphoma, largely characterized by anaplastic lymphoma kinase (ALK) positivity, resulting from the chromosomal translocation t(2;5). We report a pediatric case of ALK-positive ALCL with primary concomitant involvement of bone and central nervous system (CNS); thereafter, a literature review about pediatric primary bone and primary CNS ALCL was conducted. According to the analyzed data, our case is unique because it is characterized by the contemporary involvement of the spine and CNS. During and after chemotherapy, our patient was monitored by detecting minimal residual disease (MRD) through the analysis of fusion transcript nucleophosmin-ALK. MRD assessment, not only in bone marrow but also in peripheral blood, seems to be a very powerful tool for predicting the prognosis of pediatric ALCL patients, as already described in the literature. Moreover, as shown in our case, it could be used during the follow-up for early recognition of relapse.

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Section: Discussionmentioning

confidence: 99%

“…After a review of English literature, we identified 17 cases of pediatric primary bone ALCL (Table 2) [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18]. The median age of onset was 10 years and 82% (14/17) were male.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

Restivo

Mussolin

D’Angelo

et al. 2021

Hemato

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“…Isolated bone lymphoma was diagnosed in 3 patients (5.3%), 2 adolescents with DLBCL and a 7-year-old girl with tibial ALCL. It is extremely rare for ALCL to manifest as a primary bone lesion [22,23].…”

Section: Comprehensive Analysis Of Nhl Prevalence and Clinical Presenmentioning

confidence: 99%

Pediatric Non-Hodgkin Lymphoma: A Retrospective 14-Year Experience with Berlin-Frankfurt-Münster (BFM) Protocols from a Tertiary Care Hospital in Serbia

Dokmanović

Krstovski

Vukanic

et al. 2012

Pediatric Hematology and Oncology

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“…This case report documents an epiphyseal primary lymphoma of bone, diffuse large B-cell subtype, in the left distal femur of a 13-year-old boy. This is the 5 th documented case of epiphyseal PLB, a rare diagnosis which has only been described in four other patients to date [6–8].…”

Section: Introductionmentioning

confidence: 96%

Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone

Kenan

Kahn

Edelman

et al. 2018

Case Reports in Pathology

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Primary lymphoma of bone (PLB) confined to the epiphysis has only been described in four other patients. Due to the rarity of this entity, diagnosis has often been delayed, leading to mismanagement with adverse clinical consequences. We report a fifth case of primary epiphyseal lymphoma of bone located in the left distal medial femoral epiphysis of a 13-year-old boy. Radiographic and histologic features of PLB are discussed, along with a review of the literature and pitfalls of misdiagnosis. The patient initially presented with six months of progressive left knee pain with an associated loss of passive range of motion. Imaging revealed a mixed radiolucent lesion within the left distal medial femoral epiphysis with cortical breakthrough. A core biopsy was performed revealing a blue round cell tumor. Thanks to modern immunohistochemistry techniques, a diagnosis of primary lymphoma of bone was quickly made. The patient thus avoided further surgical intervention and received the appropriate treatment of chemotherapy, with subsequent rapid resolution of the lesion. This case highlights the necessity of including primary lymphoma of bone in all epiphyseal lesion differential diagnoses, especially in the pediatric patient population when aggressive radiographic features are present.

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Anaplastic large cell lymphoma presenting as an epiphyseal lytic lesion—a case report with clinico-pathologic correlation

Cited by 9 publications

References 12 publications

Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

Pediatric Anaplastic Large Cell Lymphoma with Concomitant Involvement of Spine and Central Nervous System: A Case Report and Review of Literature

Pediatric Non-Hodgkin Lymphoma: A Retrospective 14-Year Experience with Berlin-Frankfurt-Münster (BFM) Protocols from a Tertiary Care Hospital in Serbia

Epiphyseal Primary Diffuse Large B-Cell Lymphoma of Bone

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