Anaplastic lymphoma kinase–positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3′ ALK gene insertion to chromosome 4 q22-24

Stachurski, Dariusz; Miron, Patricia M.; Al-Homsi, Samer; Hutchinson, Lloyd; Harris, Nancy L.; Woda, Bruce A.; Wang, Sa A.

doi:10.1016/j.humpath.2006.12.019

Cited by 50 publications

(30 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Remarkably, similar complex aberrations were detected in a case of IMT in which the SEC31A-ALK fusion was originally identified. 20 Whether another case of ALK + LBCL with a cryptic insertion of the 3' end of ALK at 4q22-24 reported by Stachurski et al, 21 targets SEC31A remains to be clarified. The duplication of the ALK fusion gene found in case 1 has been recurrently reported in ALK-positive lymphoma.…”

Section: Resultsmentioning

confidence: 95%

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

et al. 2010

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 95%

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

et al. 2010

View full text Add to dashboard Cite

“…This patient had the NPM1-ALK fusion, but displayed only cytoplasmic staining. Recently, Stachurski et al [18] demonstrated a new cytogenetic aberration associated with ALK þ DLBCL, a cryptic 3 0 -ALK gene insertion into chromosome 4q22-24. ALK staining in this case was also in a focal granular cytoplasmic pattern.…”

Section: Discussionmentioning

confidence: 99%

ALK‐positive diffuse large B‐cell lymphoma: report of three cases

Lee

Kım

Kim

et al. 2008

Hematological Oncology

View full text Add to dashboard Cite

Diffuse large B-cell lymphoma positive for anaplastic lymphoma kinase (ALK(+) DLBCL) is a rare variant of diffuse large B-cell lymphoma, with characteristic morphological, immunohistochemical and cytogenetic features. Only 34 cases of ALK-positive diffuse large B-cell lymphoma have so far been reported in the literature. We examined three new cases, which showed similar characteristics to previously reported cases, but with peculiar nuclear-membrane staining for ALK protein in one patient and a 5'-ALK gene deletion in another. All of them had stage IV disease at initial presentation, with poor outcomes. The tumour cells showed immunoblastic/plasmablastic histology and were positive for ALK and Oct2, but negative for CD3, CD20, CD79a, CD30 and PAX5. The staining pattern of ALK protein was cytoplasmic in two patients and associated with the nuclear membrane in one patient. Fluorescence in situ hybridization (FISH) analysis using the ALK break-apart probe revealed ALK gene rearrangements in all three patients, with a 5'-ALK gene deletion in one patient. These three cases suggest that different types of cytogenetic aberrations may involve the ALK gene in ALK-positive diffuse large B-cell lymphoma leading to peculiar immunohistochemical staining patterns.

show abstract

“…Histologically, they display monomorphic, large immunoblastic/plasmablastic cells, which are CD138-, EMA-, CD4-, and cytoplasmic IgA-positive but lack CD30 and B-cellrestricted markers , Reichard et al 2007). ALK C DLBCL are characterized by an aggressive outcome and poor response to treatment (Reichard et al 2007, Stachurski et al 2007, Choung et al 2008, Momose et al 2009). …”

Section: Alk Fusion Proteinsmentioning

confidence: 99%

Anaplastic lymphoma kinase in human cancer

Barreca

Lasorsa

Riera

et al. 2011

Journal of Molecular Endocrinology

122

View full text Add to dashboard Cite

The receptor tyrosine kinases (RTKs) play a critical role, controlling cell proliferation, survival, and differentiation of normal cells. Their pivotal function has been firmly established in the pathogenesis of many cancers as well. The anaplastic lymphoma kinase (ALK), a transmembrane RTK, originally identified in the nucleophosmin (NPM)-ALK chimera of anaplastic large cell lymphoma, has emerged as a novel tumorigenic player in several human cancers. In this review, we describe the expression of the ALK-RTK, its related fusion proteins, and their molecular mechanisms of activation. Novel tailored strategies are briefly illustrated for the treatment of ALK-positive neoplasms.

show abstract

Anaplastic lymphoma kinase–positive diffuse large B-cell lymphoma with a complex karyotype and cryptic 3′ ALK gene insertion to chromosome 4 q22-24

Cited by 50 publications

References 12 publications

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

ALK-positive large B-cell lymphomas with cryptic SEC31A-ALK and NPM1-ALK fusions

ALK‐positive diffuse large B‐cell lymphoma: report of three cases

Anaplastic lymphoma kinase in human cancer

Contact Info

Product

Resources

About