Anaplastic Pleomorphic Xanthoastrocytoma Presenting with Musical Hallucination

Oladiran, Oreoluwa; Nwosu, Ifeanyi; Obanor, Steve; Ogbonna-Nwosu, Chinyere; Le, Brian

doi:10.1155/2018/6428492

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…Although cases are infrequent in the young age group, such neoplasm could be diagnosed in a wide range of ages and are responsible for less than one percent of all brain tumors [ 9 ]. Furthermore, seizures in general are the most common presentation, and even musical hallucination was reported [ 11 ]. Concerning the anatomical distribution, the frontal lobe is affected in the third position of supratentorial sites, and the rarest cases were described as infratentorial [ 6 ].…”

Section: Discussionmentioning

confidence: 99%

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Pleomorphic Xanthoastrocytoma of the Frontal Lobe in a Child: A Rare Entity

Furtado¹,

Filho²,

G³

et al. 2021

Cureus

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Pleomorphic xanthoastrocytoma (PXA) is an infrequent neoplasm that affects children less commonly than adults. In this case report, a four-year-old boy presented with focal seizures has diagnosed with this tumor in the frontal lobe. Complete surgical resection was achieved, and histopathological features of PXA grade II were observed. During follow-up, the patient showed improvement of the focal seizures. In spite of the pleomorphic features, the PXA had a favorable prognosis.

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Section: Discussionmentioning

confidence: 99%

“…Therefore, the authors concluded that both radiotherapy and chemotherapy are not recommended for PXA [ 6 ]. Conversely, anaplastic PXA deserves a complementary therapy [ 7 , 11 ]. However, according to the latest WHO classification of 2016 [ 15 ], PXA and anaplastic PXA were considered as distinct entities.…”

Section: Discussionmentioning

confidence: 99%

Pleomorphic Xanthoastrocytoma of the Frontal Lobe in a Child: A Rare Entity

Furtado¹,

Filho²,

G³

et al. 2021

Cureus

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“…One case report identified an uncommon but increasingly recognized anti-IgLON5 disease accompanied by MHs [13], which demonstrates the diverse and ever-changing clinical phenotypes observed in autoimmune central nervous system diseases. Chronic pain, electrical stimulation of the anterior cingulate cortex for refractory chronic pain, anaplastic pleomorphic xanthoastrocytoma, hybrid cochlear implantation, insular glioma resection, left temporal lobectomy, abdominal pain, and electroconvulsive therapy were the other causes of MHs in the NOC group [14,24,28,36,58,61,65,67].…”

Section: Not Otherwise Classifiablementioning

confidence: 97%

The phenomenon of musical hallucinations: An updated review

Al-Awad

2023

ELECTRON J GEN MED

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Introduction: Musical hallucinations (MHs) is a heterogeneous phenomenon. Multiple case reports and series have improved our understanding of this complex phenomenon. This systematic review aims to assess the available evidence regarding MHs. Methods: PubMed and ProQuest databases were searched for articles published between 2005 and 2022. The keywords used for the search were “music,” “musical,” “hallucinations,” and “hallucinosis.” Results: The search identified 421 articles; however, only 67 were selected. A total of 77 patients were selected from case reports and series. We identified 50 articles with single cases, four articles with two cases, four articles with three cases, and one article with six cases. Eight additional articles that provided information regarding the prevalence of MHs were included in the review. Conclusions: MHs are common among older individuals, women, and hearing-impaired individuals. The etiologies include psychiatric, neurological, hearing impairments, and substances. Content of MHs is typically familiar songs/music. No randomized controlled studies are available for determining the treatment for MHs.

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A case series of pediatric survivors of anaplastic pleomorphic xanthoastrocytoma

Ronsley

Dunham

Yip

et al. 2021

Neuro-Oncology Advances

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Background Anaplastic pleomorphic xanthoastrocytoma (APXA) is a rare subtype of CNS astrocytoma. They are generally treated as high-grade gliomas; however, uncertainty exists regarding the optimal therapy. Here, we report on 3 pediatric cases of APXA. Methods Our institutional database was queried for cases of APXA and 3 cases were identified. Surgical samples were processed for methylation profiling and chromosomal microarray analysis. Methylation data were uploaded to the online CNS tumor classifier to determine methylation-based diagnoses to determine copy number variations (CNVs). Results Two patients were male, 1 female, and all were aged 12 years at diagnosis. All underwent a gross total resection (GTR) and were diagnosed with an APXA. Immunohistochemical analysis demonstrated that 2 cases were BRAF V600E positive. Methylation-based tumor classification supported the APXA diagnosis in all cases. CNV analyses revealed homozygous CKDN2A deletions in all and chromosome 9p loss in 2 cases. All patients received radiation therapy (54 Gy in 30 fractions) with concurrent temozolomide. Two patients received maintenance chemotherapy with temozolomide and lomustine for 6 cycles as per the Children’s Oncology Group ACNS0423. The third patient recurred and went on to receive a second GTR and 6 cycles of lomustine, vincristine, and procarbazine. All are alive with no evidence of disease >4 years post-treatment completion (overall survival = 100%, event free survival = 67%). Conclusions The natural history and optimal treatment of this rare pediatric tumor are not well understood. This case series supports the use of adjuvant chemoradiotherapy in the treatment of APXA. The genetic landscape may be informative for optimizing treatment and prognosis.

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Anaplastic Pleomorphic Xanthoastrocytoma Presenting with Musical Hallucination

Cited by 5 publications

References 23 publications

Pleomorphic Xanthoastrocytoma of the Frontal Lobe in a Child: A Rare Entity

Pleomorphic Xanthoastrocytoma of the Frontal Lobe in a Child: A Rare Entity

The phenomenon of musical hallucinations: An updated review

A case series of pediatric survivors of anaplastic pleomorphic xanthoastrocytoma

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