Anaplastic Transformation of Follicular Thyroid Cancer in the Lung, Liver, Bone, and Adrenal Gland

Abstract

Anaplastic transformation of differentiated thyroid cancer at distant metastatic sites is extremely rare and has a poor prognosis. It usually occurs in the thyroid gland or cervical lymph nodes. Here we report a case of anaplastic transformation arising at multiple distant metastatic sites including the lung, liver, adrenal gland, bone, and lymph nodes in a patient 3 years after total thyroidectomy for follicular thyroid cancer.

Histopathological Spectrum of Non-Neoplastic and Neoplastic Lesions of Thyroid: A Descriptive Cross-sectional Study

“…1 , 8 , 17 Anaplastic transformation of FC in metastatic sites was observed in 72 years old person by Lee W et al while Nakayama R et al also reported anaplastic transformation of FC in the skeletal metastatic site in 55 years old woman. 24 , 25 We also uncovered a case of FC with anaplastic transformation in 45 years old female. Unlike the above-mentioned reports, we identified the anaplastic transformation in the primary site as opposed to the metastatic site.…”

Occult multifocal papillary thyroid carcinoma presenting as anaplastic carcinoma in the metastatic neck deposit – A rare case report along with review of literature

“…This period varied from a year to as long as 25 years. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Distant metastasis can occur rarely in lung, brain, maxilla, bone and retroperitoneum. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Sixteen out of thirty cases showed distant metastasis as depicted in Table 1.…”

“…[2][3][4][5][6][7][8][9][10][11][12][13][14][15] Distant metastasis can occur rarely in lung, brain, maxilla, bone and retroperitoneum. [2][3][4][5][6][7][8][9][10][11][12][13][14][15] Sixteen out of thirty cases showed distant metastasis as depicted in Table 1. Solomon et al, reported a case of distant metastasis where retroperitoneal metastasis showed AT, 25 years after thyroidectomy.…”

“…6 Similarly cases described by Takeshita et al, Ambilil et al, Lee W and KimD, Nakayama et al, Abe et al, Kaushalet al showed metastasis at varied interval to different sites as cited in Table 1. [7][8][9][10][11][12] Fourteen cases of AT of thyroid carcinoma were found in cervical lymph node and soft tissue (Table 2). Case reported by Khairy G was an elderly lady who had an untreated huge thyroid mass since past 10 years; was operated and found to have PTC with AT in cervical nodes.…”