Anästhesie assoziierte Rhabdomyolyse - Diagnose, Therapie und Prävention des Skelettmuskelzerfalls

Schütte, Jan Karl; Gerbershagen, Mark U.; Wappler, Frank

doi:10.1055/s-2006-949505

Cited by 3 publications

(1 citation statement)

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“…Wäh-rend bei der Verdachtsdiagnose in beiden Fällen die Zufuhr der volatilen Anästhetika unverzüg-lich beendet wird, ist die Therapie mit Dantrolen im Fall der anästhesieinduzierten Rhabdomyolyse nicht indiziert, weil sie ineffektiv ist. Hier liegt der Schwerpunkt auf einer konsequenten Therapie der Rhabdomyolyse und Hyperkaliäme [16]. Eckpunkte der Therapie sind eine adäquate Volumentherapie, eine forcierte Diurese, ggf.…”

Section: Maligne Hyperthermieunclassified

Anästhesie bei neuromuskulären Erkrankungen

Gerbershagen¹,

Wappler²

2010

Anaesthesist

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Among the neuromuscular diseases (NMDs) over 800 individual entities have been identified. The vast majority of these diseases occur very seldom but all NMDs together add up to a prevalence of 1:1,500. Accordingly the conclusion "seldom diseases are common" seems to be appropriate. The scope of NMDs is very wide varying from the affection of single muscle groups to the complete musculature, from slowly progressive to fulminant progressive forms, from perinatal to the adult manifestation as well as number, course and character of associated comorbidities. Due to the wide heterogeneity concerning NMDs it is of great importance for anesthesiologists to be knowledgeable on relevant comorbidities as well as indications and contraindications for the various anesthetics.

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Section: Maligne Hyperthermieunclassified

Anästhesie bei neuromuskulären Erkrankungen

Gerbershagen¹,

Wappler²

2010

Anaesthesist

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Letale Hyperpyrexie bei einem jugendlichen Schwerbrandverletzten nach Verkehrsunfall

et al. 2016

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After a motorcycle accident a 16-year-old patient suffered severe burns to 40.5 % of the total body surface area (TBSA) of which 37 % were deep subdermal burns. After tangential and partly epifascial necrosectomy, Integra® was used as a temporary dermis replacement material for the lower extremities, combined with extensive negative pressure wound therapy (NPWT). In the further course of the treatment the patient developed uncontrollable hyperpyrexia with a fatal outcome. Possible influencing factors, such as the dermis replacement material combined with NPWT over large areas as well as the differential diagnoses propofol infusion syndrome, heatstroke and malignant hyperthermia are discussed.

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