Anastomotic configuration and mucosal 5-aminosalicylic acid (5-ASA) concentrations in patients with crohn's disease: a GISC study

Abstract

The different mucosal concentrations in these two groups may be explained by the difference in segmental transit time induced by the different anastomotic configurations. A slower preanastomotic transit time, demonstrated in patients with end-to-side or side-to-side anastomosis, could offer a prolonged contact time between the intestinal content and the mucosa, resulting in an increase in drug absorption.

Comparing Outcomes Between Side‐to‐Side Anastomosis and Other Anastomotic Configurations After Intestinal Resection for Patients with Crohn’s Disease: A Meta‐Analysis

“…On more detailed review, four more trials were excluded because comparison was not made between an SSA group and an EA group [24][25][26][27]. Three studies were excluded because the outcomes of interest were not suitably reported [28][29][30]. A further three studies were discarded because of overlap of the patient population [31][32][33].…”