Anastomotic leakage as a risk factor for the long-term outcome after curative resection of colon cancer

Circular anastomotic experimental fibrin sealant protection in deep colorectal anastomosis in pigs in a randomized 9-day survival study

“…This rate is within the range of literature-reported clinical situations in patients [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] and could be reduced significantly by a circumferential extraluminal experimental fibrin sealant to the site of the circular anastomosis.…”

“…In this respect, Flodeen [29] analyzed 45 patients with EAL and LAL after LAR for rectal cancer. In this trial, 60 % (n=27) of symptomatic leakage was diagnosed during the initial hospital stay on median of eight postoperative days (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). However, 40 % (n=18) were diagnosed after discharge from hospital on a median of 22 postoperative days (33-172).…”

“…The rate of a clinically apparent leakage of a circular double-stapled anastomosis (CDSA) after LAR without defunctioning stoma ranges from 8 to 37.% [1][2][3][4][5][6][7][8][9][10][11]. There are additional 30 % leaks following a stapled end-to-end colorectal anastomosis that are asymptomatic or non-clinically apparent [8].…”

Fibrin Glue Does Not Improve Healing of Gastrointestinal Anastomoses: A Systematic Review

“…Anastomotic leakage is a serious complication after gastrointestinal surgery resulting in a significant increase in the 30-day mortality and morbidity rates. The mortality rate of this complication may be as high as 13-27% [1,2,3,4,5,6,7,8]. The reported anastomotic leakage rates are 1-39%, but a comparative evaluation of the studies is difficult due to the lack of standardized definitions [9,10,11].…”

800 The Relationship Between Patient Physiology, the Systemic Inflammatory Response and Survival in Patients Undergoing Curative Resection of Colorectal Cancer

“…One possible explanation is that poor patient physiology is associated with an increased likelihood of post-operative complications such as an anastomotic leak; recognised to be associated with early recurrence and cancer death, independent of tumour stage (McArdle et al, 2005;Jung et al, 2008;Marra et al, 2009). Another possible explanation, examined in this study, is that a pre-operative systemic inflammatory response reflects, in part, the existence of physiological dysfunction (Roxburgh and McMillan, 2010b).…”