Anatomic Bases of Event-Related Potentials and Their Relationship to Novelty Detection in Humans

Knight, Robert T.; Scabini, Donatella

doi:10.1097/00004691-199801000-00003

Cited by 296 publications

(225 citation statements)

References 79 publications

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“…As mentioned earlier, we selected the seed voxels for our analysis in the hippocampus because of considerable evidence in the literature about the involvement of the hippocampus in novelty detection [1,2,[5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]47]. It is also generally accepted that novelty detection involves regions beyond the hippocampus [ 1,2,12,17,19,20].…”

Section: Discussionmentioning

confidence: 99%

Memory encoding and hippocampally-based novelty/familiarity discrimination networks

et al. 2003

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Novelty discrimination refers to the ability to decide whether information is new or has been previously encountered. Recent functional neuroimaging work has demonstrated that the hippocampus plays an important function in novelty discrimination. In the study described here, we explored the idea that novelty discrimination does not depend on the hippocampus alone but involves large-scale functional neural networks consisting of spatially remote brain regions. We measured blood flow with positron emission tomography (PET) while subjects semantically encoded visually and auditorily presented situationally novel and familiar words. Following each PET scan, subjects' memory was tested with a standard yes/no recognition test. Blood flow data were analyzed with the covariance-based seed partial least squares (PLS) method. Behaviorally, subjects' recognition performance was higher for novel than familiar words. Neurally, two large-scale functional networks involving the same region of the hippocampus were identified which showed coherent activity either during the encoding of situationally novel (but not familiar) items or situationally familiar (but not novel) items. These findings indicate that different neural networks are active in the processing of situationally novel and familiar information. The observation that the hippocampus participates in both networks supports the principle of neural context.

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Section: Discussionmentioning

confidence: 99%

Memory encoding and hippocampally-based novelty/familiarity discrimination networks

et al. 2003

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“…The P3a has a shorter peak latency than does the P3b and is distributed more anteriorly than the P3b, reflecting the involvement of different neural generators (Halgren et al, 1998;Knight and Scabini, 1998). The P3a is sensitive to contextual salience (or novelty) of the eliciting stimulus, and is assumed to be a manifestation of the frontal lobe function related to orienting of attention.…”

Section: Voluntary Stimulus Productionmentioning

confidence: 99%

Voluntary stimulus production enhances deviance processing in the brain

Nittono

2006

International Journal of Psychophysiology

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Humans often get information by voluntary action. However, little is known about how stimulus processing is modulated by self-production of stimuli. In the present study, event-related brain potentials were recorded from sixteen student volunteers performing an auditory three-stimulus oddball task in two conditions. In the self condition, the stimuli were triggered by participants' voluntary button presses. In the auto condition, the same stimuli were presented automatically by a computer with the same interstimulus intervals as those in the self condition. Perceptually deviant nontarget stimuli elicited a larger P3 and a larger subsequent positivity in the self condition than in the auto condition, whereas low-deviant target stimuli elicited a P3 with equally high amplitude in both conditions. The findings suggest that voluntary stimulus production enhances orienting of attention (reflected in the P3a component) and subsequent memory updating (reflected in the P3b component) for deviant stimuli, but does not affect the response to task-relevant stimuli. Voluntary action may activate the perceptual representation of its most frequent outcomes and this anticipatory activation may make deviant stimuli more salient in the context.

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“…An earlier latency positive potential (300 to 400 ms; P3a) indexes attention switching to non-target novel events [7]. Lesion, brain imaging and intracranial studies propose anatomical and functionally distinct neural sources for the switching (P3a) and updating (P3b) mechanisms [12]. For instance, the prefrontal cortex (PFC) plays a key role in triggering the P3a potential [10], but has a less critical involvement in P3b elicitation [11].…”

Section: Introductionmentioning

confidence: 99%