Anatomic basis for differential regulation of the rostrolateral peri–locus coeruleus region by limbic afferents

Bockstaele, Elisabeth J. Van; Peoples, James; Valentino, Rita J.

doi:10.1016/s0006-3223(99)00213-9

Cited by 149 publications

(100 citation statements)

References 25 publications

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“…We demonstrate here that CRH activates LC neurons directly even when synaptic activity is prevented. This direct action is consistent with ultrastructural evidence for synaptic contacts between CRH- immunoreactive terminals and LC dendrites and by the presence of CRH 1 receptors on LC neurons (Van Bockstaele et al, 1999;Fox et al, 2002). Our in vitro studies do not, however, rule out the possibility of additional presynaptic actions of CRH in vivo.…”

Section: Site Of Action Of Crh On Lc Neuronssupporting

confidence: 75%

“…Although sharp electrodes are unlikely to achieve a good space clamp, space-clamp problems with LC neurons have been reported even in whole-cell recordings, especially when using horizontal slices (Travagli et al, 1996). We used horizontal slices to preserve the extracerulear dendritic arborizations of LC neurons because the majority of the CRH innervation of LC neurons occurs in the pericerulear region outside of the nucleus proper (Van Bockstaele et al, 1999). Washout of the intracellular messengers involved in the cAMP cascade has been reported for LC neurons Aghajanian, 1991, 1995).…”

Section: Methodological Considerationsmentioning

confidence: 99%

“…The major source of norepinephrine (NE) in the CNS, the locus ceruleus (LC), receives CRH afferents from the brainstem nuclei paragigantocellularis, prepositus hypoglossi, and Barrington's and the central nucleus of the amygdala and the paraventricular nucleus of the hypothalamus (Valentino et al, 1992;Van Bockstaele et al, 1999). Some CRH afferents preferentially target the LC proper, whereas others target the rostromedial and dorsolateral pericerulear regions (Van Bockstaele et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

“…Some CRH afferents preferentially target the LC proper, whereas others target the rostromedial and dorsolateral pericerulear regions (Van Bockstaele et al, 2001). Furthermore, CRH terminals contact LC dendrites and presynaptic terminals, thereby providing a neuroanatomical substrate for interaction between CRH and noradrenergic activity throughout the entire forebrain (Van Bockstaele et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

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Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro

Jedema¹,

Grace²

2004

J. Neurosci.

158

126

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The neuropeptide corticotropin-releasing hormone (CRH) activates locus ceruleus (LC) neurons, thereby increasing norepinephrine levels throughout the CNS. Despite anatomical and physiological evidence for CRH innervation of the LC, the mechanism of CRH-evoked activation of LC neurons is unknown. Moreover, given the apparent absence of mRNA for CRH receptors in LC neurons, the exact location of action of CRH within the cerulear region is debated. Using in vitro intracellular recordings from rat brainstem, we examined whether CRH exerts a direct effect on LC neurons and which ionic currents are likely affected by CRH. We demonstrate that CRH dose-dependently increases the firing rate of LC neurons through a direct (TTX-and cadmium-insensitive) mechanism by decreasing a potassium conductance. The CRH-evoked activation of LC neurons is, at least in part, mediated by CRH 1 receptors and a cAMP-dependent second messenger system. These data provide additional support that CRH functions as an excitatory neurotransmitter in the LC and the hypothesis that dysfunction of the CRH peptidergic and noradrenergic systems observed in patients with mood and anxiety disorders are functionally related.

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Section: Site Of Action Of Crh On Lc Neuronssupporting

confidence: 75%

Section: Methodological Considerationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro

Jedema¹,

Grace²

2004

J. Neurosci.

158

126

View full text Add to dashboard Cite

show abstract

“…It works by having an electrode attached from a pacemaker implanted on the left side of the chest to the left vagus nerve in the neck 106,107 . Although its mechanism of action remains elusive, it has been suggested that impulses from the vagus nerve are transmitted to the following regions: locus ceruleus, raphe nuclei, and nucleus tractus soliarious, which then project to other regions of the brain, ultimately affecting the limbic system [109][110][111][112][113] . Therefore, this may be a less focal method of electrical stimulation.…”

Section: Vagus Nerve Stimulation (Vns)mentioning

confidence: 99%

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

Brunoni

Teng

Correa³

et al. 2010

Arq. Neuro-Psiquiatr.

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The use of neuromodulation as a treatment for major depressive disorder (MDD) has recently attracted renewed interest due to development of other non-pharmacological therapies besides electroconvulsive therapy (ECT) such as transcranial magnetic stimulation (TMS), transcranial direct current stimulation (tDCS), deep brain stimulation (DBS), and vagus nerve stimulation (VNS). Method: We convened a working group of researchers to discuss the updates and key challenges of neuromodulation use for the treatment of MDD. results: The state-of-art of neuromodulation techniques was reviewed and discussed in four sections: [1] epidemiology and pathophysiology of MDD; [2] a comprehensive overview of the neuromodulation techniques; [3] using neuromodulation techniques in MDD associated with non-psychiatric conditions; [4] the main challenges of neuromodulation research and alternatives to overcome them. Discussion: ECT is the first-line treatment for severe depression. TMS and tDCS are strategies with a relative benign profile of side effects; however, while TMS effects are comparable to antidepressant drugs for treating MDD; further research is needed to establish the role of tDCS. DBS and VNS are invasive strategies with a possible role in treatment-resistant depression. In summary, MDD is a chronic and incapacitating condition with a high prevalence; therefore clinicians should consider all the treatment options including invasive and non-invasive neuromodulation approaches. Key words: comprehensive review, major depressive disorder, ECT, TMS, clinical guidelines.Estratégias de neuromodulação para o tratamento da depressão maior: desafios e recomendações de uma força-tarefa rEsuMo O uso de técnicas de neuromodulação para o tratamento do transtorno depressivo maior (TDM) tem despertado um renovado interesse nos últimos anos com o desenvolvimento de outras intervenções não-farmacólogicas além da eletroconvulsoterapia (ECT), como a estimulação magnética transcraniana (EMT), a estimulação transcraniana por corrente continua (ETCC), a estimulação cerebral profunda (DBS) e a estimulação de nervo vago (VNS). Método: Nós organizamos um grupo de trabalho com vários pesquisadores para discutir os avanços recentes e os principais desafios para o uso da neuromodulação no tratamento os principais desafios da pesquisa na neuromodulação e alternativas para superá-los. Discussão: ECT é o tratamento de primeira linha para depressão grave. EMT e ETCC são estratégias com um perfil benigno de efeitos adversos; contudo, enquanto os efeitos da EMT são comparáveis ao das drogas antidepressivas para o tratamento da TDM, a eficácia da ETCC ainda precisa ser estabelecida por mais pesquisas clínicas. DBS e VNS são intervenções invasivas com um papel possível para a depressão refratária. Em resumo, TDM é uma condição crônica, incapacitante e de alta prevalência; portanto na prática clínica todas as opções de tratamento possíveis, incluindo as farmacológicas e não-farmacológicas, devem ser consideradas. Palavras-chave: artigo de revisão, tra...

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More than one-half of a decade of experience with venlafaxine dual serotonin-norepinephrine reuptake inhibitor

Nemeroff¹

2000

Depress. Anxiety

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Anatomic basis for differential regulation of the rostrolateral peri–locus coeruleus region by limbic afferents

Cited by 149 publications

References 25 publications

Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro

Corticotropin-Releasing Hormone Directly Activates Noradrenergic Neurons of the Locus Ceruleus RecordedIn Vitro

Neuromodulation approaches for the treatment of major depression: challenges and recommendations from a working group meeting

More than one-half of a decade of experience with venlafaxine dual serotonin-norepinephrine reuptake inhibitor

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