Anatomic Basis for Lymph Node Counts as Measure of Lymph Node Dissection Extent: A Cadaveric Study

Davies, Judson D.; Simons, Christopher M.; Ruhotina, Nedim; Barocas, Daniel A.; Clark, Peter E.; Morgan, Todd M.

doi:10.1016/j.urology.2012.10.025

Cited by 44 publications

(25 citation statements)

References 17 publications

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“…The extent (unilateral vs. bilateral) of PLND was defined by the treating surgeon. Although this variable would have been of value in our assessment, data from PLND in bladder cancer suggest that substantial individual differences exist in the lymph node numbers within specific dissection templates [25]. This combined with potential variations in pathological assessment of nodal specimen at different centers suggests that node count may have limited utility as a surrogate for the anatomical extent of PLND.…”

Section: Discussionmentioning

confidence: 99%

Extent of pelvic lymph node dissection in penile cancer may impact survival

et al. 2015

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Section: Discussionmentioning

confidence: 99%

Extent of pelvic lymph node dissection in penile cancer may impact survival

et al. 2015

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“…The authors indicated that upper level of dissection was more important than the number of lymph nodes removed. [22] In another publication, Roth et al [23] dissected 13-72 lymph nodes using standard PLND. Canda et al [24] indicated that they dissected an average of 24 lymph nodes in their series.…”

Section: Discussionmentioning

confidence: 99%

Robotic radical cystectomy for the management of bladder cancer: Analysis of operative and pathological outcomes of eighteen patient

İslamoğlu

Anıl

Erol

et al. 2018

Turkish Journal of Urology

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Objective: To present the surgical and pathological results of robotic radical cystectomy (RRC) operations performed in our clinic. Material and methods:A total of 18 patients, who underwent RRC and intracorporeal urinary diversion between October 2016 and September 2017 for clinically localized bladder cancer in our clinic, were included in the study. The results were evaluated under three headings. 1. operative outcomes (total operation time, perioperative blood loss, postoperative hematocrit decrease) 2. recovery period (pull-off drain day, hospitalization time) 3. oncological results (pathologic stage, surgical margin, number, and characteristics of lymph nodes removed). Complications within the postoperative 30-day period, were evaluated and the Clavien classification system was used to classify the complications. Results:The mean age of the patients was 64.4 (52-80) years. Seventeen male patients and one female patient underwent robotic cystectomy. At the operative outcomes, the mean blood loss was 325 mL, and the mean hematocrit decrease was 3.15%. The mean duration of the surgery was 471 minutes (330-630), while the median operative time was 450 minutes. Complications occured in 6 patients during the early postoperative period. Six of them (75%) had minor complications (Clavien grade 1), two patients (25%) had major complications (Clavien grade 4). Conclusion:Our initial experience with RRC is that, this surgical technique has acceptable operative, oncological and short-term clinical outcomes. However, prospective randomized studies are needed to assess whether there is a clear advantage compared to open surgery.

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“…Despite the fact that the rate of clinically significant PC was very similar between centers, one cannot rule out an interobserver variability in the pathological assessment of RC specimens. Although we report on the number of retrieved lymph nodes as a surrogate marker for the meticulousness of pelvic LND, its association to the anatomical extent of LND is limited [21]. However, all patients were treated in academic centers by surgeons dedicated to the management of patients with muscle-invasive BC.…”

Section: Discussionmentioning

confidence: 99%

Prognostic Significance of Incidental Prostate Cancer at Radical Cystoprostatectomy for Bladder Cancer

Gakis¹,

Rink²,

Fritsche³

et al. 2016

Urol Int

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Objective: The aim of the study was to evaluate the impact of the clinical significance of incidental prostate cancer (PC) on overall survival (OS) after radical cystoprostatectomy (RC) for bladder cancer (BC). Methods: A total of 822 consecutive men underwent RC in 3 academic centers between 1996 and 2011. The clinical significance of incidental PC was determined according to the Epstein criteria. The Kaplan-Meier analysis with log-rank was used to investigate the impact of PC on OS and univariate and multivariate Cox regression analyses for risk factors of OS. The median follow-up was 36 months (interquartile range 10-49). Results: Of the 822 men, 117 (14.2%) had clinically significant, 243 (29.6%) insignificant and 462 (56.2) no PC at RC. Men with PC were at higher risk for lymphovascular invasion (LVI) of BC compared to men without PC (p < 0.001). The 5-year OS for men with clinically significant, insignificant and no PC was 33.3, 51.3 and 51.5%, respectively (p = 0.050). In the subgroup of pN0 patients (n = 601), clinically significant PC was significantly associated with inferior OS (p = 0.044) but not in multivariable analysis (p = 0.46). Conclusions: We did not find the clinical significance of incidental PC to be an independent predictor. However, the positive correlation between incidental PC and LVI of BC deserves further investigation.

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Anatomic Basis for Lymph Node Counts as Measure of Lymph Node Dissection Extent: A Cadaveric Study

Cited by 44 publications

References 17 publications

Extent of pelvic lymph node dissection in penile cancer may impact survival

Extent of pelvic lymph node dissection in penile cancer may impact survival

Robotic radical cystectomy for the management of bladder cancer: Analysis of operative and pathological outcomes of eighteen patient

Prognostic Significance of Incidental Prostate Cancer at Radical Cystoprostatectomy for Bladder Cancer

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