Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder

Ahn, Mary S.; Breeze, Janis L.; Makris, Nikos; Kennedy, David N.; Hodge, Steven; Herbert, Martha R.; Seidman, Larry J.; Biederman, Joseph; Caviness, Verne S.; Frazier, Jean A.

doi:10.1016/j.jad.2007.04.015

Cited by 45 publications

(35 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, putamen activation has been found elevated in fMRI studies of bipolar youth (Blumberg et al, 2003; Chang et al, 2004; Rich et al, 2006). Globus pallidus volume has not been reported abnormal in youth with BD (DelBello et al, 2004; Ahn et al, 2007). In youth with ADHD, both putamen and globus pallidus volumes have been reported decreased compared with controls (Ellison-Wright et al, 2008; Qiu et al, 2009).…”

Section: Discussionmentioning

confidence: 90%

“…Putamen volumes followed the same patterns as for caudate, whereas GP volume was affected only by BD diagnosis (increased). Putamen volume has previously been found increased in some (DelBello et al, 2004) but not all studies of youth with BD (Ahn et al, 2007) or in offspring of bipolar patients (Hajek et al, 2009). However, putamen activation has been found elevated in fMRI studies of bipolar youth (Blumberg et al, 2003; Chang et al, 2004; Rich et al, 2006).…”

Section: Discussionmentioning

confidence: 92%

See 1 more Smart Citation

Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

Liu

Howe

Garrett

et al. 2011

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

The most prevalent comorbid disorder in pediatric bipolar disorder (BD) is attention-deficit/hyperactivity disorder (ADHD). As caudate volume abnormalities have been demonstrated in both BD and ADHD, this study sought to determine whether these findings could be attributed to separable effects from either diagnosis. High resolution anatomical magnetic resonance (MRI) images were obtained from youth in 4 groups: BD with comorbid ADHD (n = 17), BD without comorbid ADHD (n = 12), youth with ADHD alone (n = 11), and healthy control subjects (n = 24). Caudate, putamen, and globus pallidus volumes were manually traced for each subject using Brain Image Java software by a reliable rater blinded to diagnosis. There was a significant effect of diagnosis on striatal volumes, with ADHD associated with decreased caudate and putamen volumes, and BD associated with increased caudate, putamen, and globus pallidus volumes. Thus, the presence or absence of comorbid ADHD in patients with BD was associated with distinct alterations in caudate volumes, suggesting that these groups have different, but related, mechanisms of neuropathology.

show abstract

Section: Discussionmentioning

confidence: 90%

Section: Discussionmentioning

confidence: 92%

Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

Liu

Howe

Garrett

et al. 2011

Psychiatry Research: Neuroimaging

View full text Add to dashboard Cite

show abstract

“…Besides, Yamashita K et al showed that the trend for rightward asymmetry in caudate volume and the asymmetry index increased with age [31]. Moreover, Xu et al showed a trend for rightward asymmetry in the volume of caudate and putamen nucleus in both sexes [30] while Ahn et al showed no significant asymmetry in the striate nucleus [32]. Besides, this study showed that elder men exhibited significant age-related asymmetry in the putamen volume which was not observed in women.…”

Section: Discussionmentioning

confidence: 99%

Morphometric and volumetric study of caudate and putamen nuclei in normal individuals by MRI: Effect of normal aging, gender and hemispheric differences.

et al. 2013

View full text Add to dashboard Cite

SummaryBackground:The aim of this study was to determine age, gender, and hemispheric differences in the volume of the human neostriatum (striatum) nucleus in healthy humans.Material/Methods:This study was performed on 120 normal human subjects (60 males, 60 females, right-handed) 15–65 years old, divided into two groups: young (<40 yrs) and old (=≥40 yrs). Sectional brain images were obtained via magnetic resonance imaging (MRI), analyzed and processed using the Image-J software, and the striatum volume was calculated using the Cavalieri’s principle, retrospectively.Results:The analyses revealed bilateral age-related shrinkage of the putamen in both genders and the putamen and caudate nucleus were significantly smaller in older than in younger subjects (P-value <0.001). The age-related shrinkage of the caudate and putamen nucleus in men and women was about 5%, 5% and 4%, 4%, respectively, and there were statistically significant volume differences between males and females (P-value <0.05). In both genders, a significant rightward asymmetry was observed in the caudate and putamen nucleus (3.89%, 4.21% in men and 4.51%, 3.32% in women).Conclusions:Bilateral age-related shrinkage and rightward asymmetry of the striate nucleus was found in healthy adults and there were significant volume differences between men and women. Obtained results provide useful baseline data on age and gender-related changes of the volume of the striatum.

show abstract

“…A recent study of 46 youths with bipolar disorder and 22 healthy controls found a trend toward enlargement of the right nucleus accumbens (an area within the basal ganglia) in those with bipolar disorder [14]. However, other studies of adults and youths have not shown consistent differences in basal ganglia areas [3••,5].…”

Section: Neuroanatomic Observationsmentioning

confidence: 99%

Biologic basis of bipolar disorder in children and adolescents

Kloos

Weller²,

Weller³

2008

Curr Psychiatry Rep

View full text Add to dashboard Cite

Bipolar disorder is a serious and difficult-to-treat condition in any age group. In childhood and adolescence, diagnosis and treatment present specific challenges, as the disorder often manifests in atypical presentations, such as marked irritability and frequent alterations of mood states not typically seen in adults. The lack of double-blind, placebo-controlled studies in pediatric populations also leads to many difficult pharmacologic challenges. In this paper, we review available studies in neuroanatomy, neurochemistry, neurocognitive functioning, and genetics to further explore the underlying neurobiologic mechanisms of child and adolescent bipolar disorder. Future investigation should elicit distinct mechanisms for diagnosing and treating bipolar disorder from a neurobiologic perspective.

show abstract

Anatomic brain magnetic resonance imaging of the basal ganglia in pediatric bipolar disorder

Cited by 45 publications

References 32 publications

Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

Striatal volumes in pediatric bipolar patients with and without comorbid ADHD

Morphometric and volumetric study of caudate and putamen nuclei in normal individuals by MRI: Effect of normal aging, gender and hemispheric differences.

Biologic basis of bipolar disorder in children and adolescents

Contact Info

Product

Resources

About