Anatomic connections between nucleus reticularis rostroventrolateralis and some medullary cardiovascular sites in the rat

Chan, Samuel H.H.; Chan, Julie Y.H.; Ong, B.T.

doi:10.1016/0304-3940(86)90633-6

Cited by 17 publications

(2 citation statements)

References 16 publications

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“…Anatomic studies using anterograde and retrograde transport have shown that there is a projection from the midline medulla to the RVLM, but this appears to arise mainly from neurons located more rostral than the CMM sympathoinhibitory region (2,19,22,26,30). Thus the available evidence suggests that CMM-evoked sympathoinhibition is unlikely to be mediated by a direct monosynaptic projection to RVLM presympathetic neurons.…”

Section: Discussionmentioning

confidence: 98%

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Potas

Dampney

2003

American Journal of Physiology-Regulatory, Integrative and Comp

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Potas, J. R., and R. A. L. Dampney. Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway. Am J Physiol Regul Integr Comp Physiol 284: R1071-R1078, 2003. First published December 19, 2002 10.1152 10. /ajpregu.00559.2002tamate stimulation of the caudal midline medulla (CMM) causes profound sympathoinhibition due to GABAergic inhibition of presympathetic neurons in the rostral ventrolateral medulla (RVLM). We investigated whether the sympathoinhibitory pathway from CMM to RVLM, like the central baroreceptor reflex pathway, includes a glutamatergic synapse in the caudal ventrolateral medulla (CVLM). In pentobarbital sodium-anesthetized rats, the RVLM on one side was inhibited by a muscimol microinjection. Then the response evoked by glutamate microinjections into the CMM or by baroreceptor stimulation was determined before and after 1) microinjection of the GABA receptor antagonist bicuculline into the RVLM on the other side or 2) microinjections of the glutamate receptor antagonist kynurenate bilaterally into the CVLM. Bicuculline in the RVLM greatly reduced both CMM-and baroreceptorevoked sympathoinhibition. Compared with the effect of vehicle solution, kynurenate in the CVLM greatly reduced baroreceptor-evoked sympathoinhibition, whereas its effect on CMMevoked sympathoinhibition was not different from that of the vehicle solution. These findings indicate that the output pathway from CMM sympathoinhibitory neurons, unlike the baroreceptor and other reflex sympathoinhibitory pathways, does not include a glutamatergic synapse in the CVLM.

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Section: Discussionmentioning

confidence: 98%

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Potas

Dampney

2003

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Whereas the responses of sympathetic outflows to stimulation of vlPAG neurons have not been examined, the activity of RVLM neurons can be inhibited by electrical stimulation in the vlPAG (37,39), an effect that may be mediated by an indirect pathway through the raphe (39). Sympathoinhibition that can be evoked from raphe neurons is thought to be mediated in part by raphe-spinal projections (27), but there is evidence for raphe-RVLM projections (9,28,34,36) and axonal collaterals directed to RVLM from raphe-spinal axons (2,26).…”

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confidence: 99%

Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT_1A receptors in the RVLM

Bago

Dean

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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The role of 5-hydroxytryptamine 1A (5-HT(1A)) receptors located in the rostral ventrolateral medulla (RVLM) in the mediation of a sympathoinhibitory and depressor response elicited from the ventrolateral periaqueductal gray (vlPAG) matter of the midbrain was examined in pentobarbital sodium-anesthetized rats. Activation of neurons in the vlPAG evoked a decrease in renal and lumbar sympathetic nerve activities and a decrease in arterial blood pressure. After microinjection of the specific 5-HT(1A)-receptor antagonist WAY-100635 into the pressor area of the RVLM, the vlPAG-evoked sympathoinhibition and hypotension was attenuated to control levels (7 of 15 animals) or converted into a sympathoexcitation and pressor response (8 of 15 animals). Baroreflex inhibition of sympathetic nerve activity was not impaired by microinjection of WAY into the sympathoexcitatory region of the RVLM. These data suggest that sympathoinhibition and hypotension elicited by activation of neurons in the vlPAG are mediated by 5-HT(1A) receptors in the RVLM.

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The Panicogenic Effects of Cholecystokinin-Tetrapeptide Are Antagonized by L-365,260, a Central Cholecystokinin Receptor Antagonist, in Patients With Panic Disorder

Bradwejn

Koszycki²,

Tertre³

et al. 1994

Arch Gen Psychiatry

165

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Anatomic connections between nucleus reticularis rostroventrolateralis and some medullary cardiovascular sites in the rat

Cited by 17 publications

References 16 publications

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT_1A receptors in the RVLM

The Panicogenic Effects of Cholecystokinin-Tetrapeptide Are Antagonized by L-365,260, a Central Cholecystokinin Receptor Antagonist, in Patients With Panic Disorder

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Anatomic connections between nucleus reticularis rostroventrolateralis and some medullary cardiovascular sites in the rat

Cited by 17 publications

References 16 publications

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Sympathoinhibitory pathway from caudal midline medulla to RVLM is independent of baroreceptor reflex pathway

Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT1A receptors in the RVLM

The Panicogenic Effects of Cholecystokinin-Tetrapeptide Are Antagonized by L-365,260, a Central Cholecystokinin Receptor Antagonist, in Patients With Panic Disorder

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Sympathoinhibition from ventrolateral periaqueductal gray mediated by 5-HT_1A receptors in the RVLM