Anatomic guide and sonography for surgical repair of leg muscle lacerations

Ballard, David H.; Campbell, Kevin J.; Hedgepeth, Krystle B.; Hollister, Anne M.; Simoncini, Alberto; Pahilan, M. Elaine; Youssef, Asser M.

doi:10.1016/j.jss.2013.03.037

Cited by 5 publications

(4 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Skeletal muscle has a remarkable capacity of self-repair and regeneration, particularly following recoverable injuries like contusion and laceration injuries [Hayashi et al, 2012;Ballard et al, 2013;Delos et al, 2013;Oliva et al, 2013;Cameron and Owens, 2014]. This inherent regenerative capacity of the muscle relies primarily on quiescent satellite cells located beneath the basal lamina of myofibers that are activated upon injury.…”

Section: Introductionmentioning

confidence: 99%

A Porcine Urinary Bladder Matrix Does Not Recapitulate the Spatiotemporal Macrophage Response of Muscle Regeneration after Volumetric Muscle Loss Injury

Aurora¹,

Corona²,

Walters³

2016

Cells Tissues Organs

View full text Add to dashboard Cite

Volumetric muscle loss (VML) results in irrecoverable loss of muscle tissue making its repair challenging. VML repair with acellular extracellular matrix (ECM) scaffolds devoid of exogenous cells has shown improved muscle function, but limited de novo muscle fiber regeneration. On the other hand, studies using minced autologous and free autologous muscle grafts have reported appreciable muscle regeneration. This raises the fundamental question whether an acellular ECM scaffold can orchestrate the spatiotemporal cellular events necessary for appreciable muscle fiber regeneration. This study compares the macrophage and angiogenic responses including the remodeling outcomes of a commercially available porcine urinary bladder matrix, MatriStem™, and autologous muscle grafts. The early heightened and protracted M1 response of the scaffold indicates that the scaffold does not recapitulate the spatiotemporal macrophage response of the autograft tissue. Additionally, the scaffold only supports limited de novo muscle fiber formation and regressing vessel density. Furthermore, scaffold remodeling is accompanied by increased presence of transforming growth factor and α-smooth muscle actin, which is consistent with remodeling of the scaffold into a fibrotic scar-like tissue. The limited muscle formation and scaffold-mediated fibrosis noted in this study corroborates the findings of recent studies that investigated acellular ECM scaffolds (devoid of myogenic cells) for VML repair. Taken together, acellular ECM scaffolds when used for VML repair will likely remodel into a fibrotic scar-like tissue and support limited de novo muscle fiber regeneration primarily in the proximity of the injured musculature. This is a work of the US Government and is not subject to copyright protection in the USA. Foreign copyrights may apply. Published by S. Karger AG, Basel

show abstract

Section: Introductionmentioning

confidence: 99%

A Porcine Urinary Bladder Matrix Does Not Recapitulate the Spatiotemporal Macrophage Response of Muscle Regeneration after Volumetric Muscle Loss Injury

Aurora¹,

Corona²,

Walters³

2016

Cells Tissues Organs

View full text Add to dashboard Cite

show abstract

“…A ultrassonografia também pode ser útil para a realização de procedimentos terapêuticos e no tratamento cirúrgico das lesões musculares. 44,45 Tratamento cirúrgico Há indicações precisas nas quais a intervenção cirúrgica é necessária. Estas indicações incluem: pacientes com grandes hematomas intramusculares, lesões ou roturas completas (grau III) com pouca ou nenhuma musculatura agonista associada e lesões parciais nas quais mais da metade do músculo esteja roto.…”

Section: Ultrassomunclassified

“…Ultrasound may also be useful for the performance of therapeutic procedures and in the surgical treatment of muscle injuries. 44 45 …”

Section: Treatmentmentioning

confidence: 99%

See 1 more Smart Citation

Lesão muscular: Fisiopatologia, diagnóstico e tratamento

SantAnna

Pedrinelli

Hernandez

et al. 2022

Rev Bras Ortop (Sao Paulo)

View full text Add to dashboard Cite

ResumoO tecido muscular esquelético possui a maior massa do corpo humano, correspondendo a 45% do peso total. As lesões musculares podem ser causadas por contusões, estiramentos ou lacerações. A atual classificação separa as lesões entre leves, moderadas e graves. Os sinais e sintomas das lesões grau I são edema e desconforto; grau II, perda de função, gap e equimose eventual; grau III, rotura completa, dor intensa e hematoma extenso. O diagnóstico pode ser confirmado por ultrassom (dinâmico e barato, porém examinador-dependente); e ressonância magnética (RM) (maior definição anatômica). A fase inicial do tratamento se resume à proteção, ao repouso, ao uso otimizado do membro afetado e crioterapia. Anti-inflamatórios não hormonais (AINHs), ultrassom terapêutico, fortalecimento e alongamento após a fase inicial e amplitudes de movimento sem dor são utilizados no tratamento clínico. Já o cirúrgico possui indicações precisas: drenagem do hematoma, reinserção e reforço musculotendíneos.

show abstract

Triceps Surae

Orlandi

Corazza

2014

Ultrasound Anatomy of Lower Limb Muscles

View full text Add to dashboard Cite

Anatomic guide and sonography for surgical repair of leg muscle lacerations

Cited by 5 publications

References 13 publications

A Porcine Urinary Bladder Matrix Does Not Recapitulate the Spatiotemporal Macrophage Response of Muscle Regeneration after Volumetric Muscle Loss Injury

A Porcine Urinary Bladder Matrix Does Not Recapitulate the Spatiotemporal Macrophage Response of Muscle Regeneration after Volumetric Muscle Loss Injury

Lesão muscular: Fisiopatologia, diagnóstico e tratamento

Triceps Surae

Contact Info

Product

Resources

About