Anatomic mapping and clinicopathologic analysis of benign acral melanocytic neoplasms: A comparison between adults and children

Kim, Na Hee; Choi, Yoo Duk; Seon, Hyun Ju; Lee, Jee-Bum; Yun, Sook Jung

doi:10.1016/j.jaad.2017.02.041

Cited by 15 publications

(26 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nodular melanoma (NM) and superficial spreading melanoma (SSM) are not common in acral melanoma (Jung et al, 2013). Acral melanocytic nevus, which sometimes can show atypical features, is important in the differential diagnosis of acral melanoma along with clinicopathological correlations (Bravo Puccio and Chian, 2011; Kim et al, 2017). Recently, somatic oncogenic mutations in cutaneous melanoma have emerged as both effective biomarkers and therapeutic targets.…”

Section: Introductionmentioning

confidence: 99%

Genetic Alterations in Primary Acral Melanoma and Acral Melanocytic Nevus in Korea: Common Mutated Genes Show Distinct Cytomorphological Features

Moon

Choi

Kim

et al. 2018

Journal of Investigative Dermatology

Self Cite

View full text Add to dashboard Cite

Acral melanoma occurring on the palms, soles, and nails is the most common subtype of cutaneous melanoma in Asians. Genetic alterations in acral melanoma and acral melanocytic nevus are not well known. We performed next-generation sequencing and evaluated the correlations between genetic information and the clinicopathologic characteristics from 85 Korean patients with acral melanocytic neoplasms. Of the 64 patients with acral melanoma, most had lesions at the T2 stage or higher, and the heel was the most common anatomical site of melanoma (n = 34 [53.1%]). The five most common mutations were BRAF (22 [34.4%]), NRAS (14, [21.9%]), NF1 (11, [17.2%]), GNAQ (12, [17.2%]), and KIT (7, [10.9%]). In the 21 acral melanocytic nevi, those five gene mutations were also common. Copy number variations were also frequently detected in 75% of acral melanomas and 47.6% of acral melanocytic nevi, and amplification was more common than deletion in both lesions. BRAF mutation was associated with round epithelioid cells and NRAS and NF1 mutations with bizarre cells. NF1 and GNAQ mutations showed elongated and spindle cells with prominent dendrites in acral melanomas. KIT mutations were common in amelanotic acral melanoma. This study suggests that common mutated genes are associated with distinct cytomorphological features in acral melanocytic lesions.

show abstract

Section: Introductionmentioning

confidence: 99%

Genetic Alterations in Primary Acral Melanoma and Acral Melanocytic Nevus in Korea: Common Mutated Genes Show Distinct Cytomorphological Features

Moon

Choi

Kim

et al. 2018

Journal of Investigative Dermatology

Self Cite

View full text Add to dashboard Cite

show abstract

“…These nevi may also occur on the volar surface of the fingers and toes. Acral melanocytic nevi have a different distribution on volar sites than acral melanomas, and primarily affect non-weight-bearing areas [ 13 , 14 , 15 ]. Most of these lesions present as brown-to-black small (less than 6 mm) macules or papules.…”

Section: Acral Melanocytic Nevusmentioning

confidence: 99%

Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective

Park

Yun

2022

Dermatopathology

View full text Add to dashboard Cite

Acral melanocytic neoplasms, including acral melanocytic nevus and acral melanoma, are common melanocytic lesions in Asian populations. Both lesions occur on the volar surface of the hands and feet, and on nail units. Acral melanocytic nevi occur on the arch area of the sole, whereas acral melanomas frequently occur on weight-bearing areas of the sole, and on the fingernails. Therefore, the development of acral melanoma may be associated with chronic pressure, physical stress, or trauma. Dermoscopy is a useful adjunctive diagnostic tool for differential diagnosis. Acral melanocytic nevus is characterized by a parallel furrow pattern, whereas acral melanoma has a parallel ridge pattern. Genetic alterations are also different between the two types of lesion. BRAF and NRAS mutations are common in acral melanocytic nevus, whereas acral melanoma shows lower rates of KIT, NF1, BRAF, and NRAS mutations and remarkable copy number variations in genes such as CCND1, CDK4, hTERT, PAK1, and GAB2. Sentinel lymph node biopsy is important for staging and prognosis. Contemporary treatments for melanoma include targeted therapy for mutations and immunotherapy, such as anti-PD1 inhibitors.

show abstract

“…2 AMs are more common on certain weight-bearing areas of the feet in Japanese and white patients 3,4 ; acral melanocytic nevi (AMN) are more common on noneweight-bearing areas in Korean patients. 5 II, available online at www.jaad. org).…”

Section: Density and Distribution Of Acral Melanocytic Nevi And Acral Melanomas On The Plantar Surface Of The Footmentioning

confidence: 99%

“…3 Additional studies found AMN concentrated in noneweight-bearing areas of the feet. 5 A recent study using targeted sequencing of AM and AMN found that the mutational profile of AMN was akin to common cutaneous nevi. 1 Future studies are needed to delineate the mutational landscape and evolutionary pathways of AM and AMN.…”

Section: Density and Distribution Of Acral Melanocytic Nevi And Acral Melanomas On The Plantar Surface Of The Footmentioning

confidence: 99%

Density and distribution of acral melanocytic nevi and acral melanomas on the plantar surface of the foot

Ghanavatian

Costello

Buras

et al. 2019

Journal of the American Academy of Dermatology

View full text Add to dashboard Cite

Anatomic mapping and clinicopathologic analysis of benign acral melanocytic neoplasms: A comparison between adults and children

Cited by 15 publications

References 24 publications

Genetic Alterations in Primary Acral Melanoma and Acral Melanocytic Nevus in Korea: Common Mutated Genes Show Distinct Cytomorphological Features

Genetic Alterations in Primary Acral Melanoma and Acral Melanocytic Nevus in Korea: Common Mutated Genes Show Distinct Cytomorphological Features

Acral Melanocytic Neoplasms: A Comprehensive Review of Acral Nevus and Acral Melanoma in Asian Perspective

Density and distribution of acral melanocytic nevi and acral melanomas on the plantar surface of the foot

Contact Info

Product

Resources

About