“…For a sinonasal variant to be considered relevant, 1 of the following 4 must be true: The variant impairs normal drainage pathways, hinders endoscopic access to distal areas, serves as a focus for occult disease, or increases the risk of surgical error. 1 Examples of anatomic variants detectable on CT that may increase the risk of iatrogenic injury include sphenoethmoid (Onodi) cells, optic nerve or internal carotid artery protrusion into the sphenoid sinus, insertion of the intersphenoid sinus septum onto the carotid canal, and aeration of the anterior clinoid process. A sphenoethmoid cell is a posterior ethmoid cell that pneumatizes superiorly above the sphenoid sinus and posteriorly beyond the anterior sphenoid face, with the optic nerve being intimately related to its lateral wall.…”