Saphenous nerve entrapment is a painful condition of the thigh. It is commonly managed conservatively, but there is a lack of consensus on the application of new treatment options such as injections with platelet rich plasma (PRP) or sugar water 5% (S5W). Over the last decade, regional PRP and S5W injections have become more recognized for the treatment of orthopedic complaints, sports injuries and peripheral neuropathies because of easy application and interesting safety profile. Sugar water injections also come with a low cost. This article describes a 44-year-old runner suffering from bilateral pain in the inner thighs, knees and inner calves for two years. He was treated successfully with three weekly ultrasound-guided S5W injections. This case report is an invitation to design more research to confirm whether this novel approach may become one of the new tools for athletes suffering from saphenous nerve entrapment.