Anatomical Classification of the Developmental Glaucomas

Hoskins, H. Dunbar; Shaffer, Robert N.; Hetherington, John

doi:10.1001/archopht.1984.01040031081030

Cited by 115 publications

(46 citation statements)

References 5 publications

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“…One is associated with iridocorneal angle abnormal ities, such as high insertion of the iris root, absence o f the angle recess, abnormal width of the trabecular band, promi nent line of Schwalbe and poorly developed scleral spur. This type has been termed developmental glaucoma or goniodysgenetic glaucoma [4,5]. The other form of juvenile glaucoma is not associated with gonioscopic abnormalities and has been considered to be an early-onset form of pri mary open angle glaucoma (POAG) and termed juvenile POAG [6,7], In some cases ofjuvenile glaucoma autosomal dominant inheritance has been reported.…”

Section: Introductionsupporting

confidence: 43%

Ultrastructural Changes in the Trabecular Meshwork of Juvenile Glaucoma

Furuyoshi

Furuyoshi²,

Futa³

et al. 1997

Ophthalmologica

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Trabeculectomy specimens from 11 patients with juvenile glaucoma were studied by electron microscopy and quantitatively evaluated. In all cases, large amounts of extracellular material arranged in a fingerprint-like pattern, resembling basement-membrane-like material (FBM) was found, similar to that described in steroid-induced glaucoma. This material was found mainly within the inner cribriform and outer corneoscleral regions of the trabecular meshwork, and caused the cribriform layer to be greatly thickened. FBM was also intimately associated with trabecular cells, which frequently appeared activated. In 3 cases, there was also an increase in fine fÍbrillar material which resembled that found in eyes with steroid-induced glaucoma. The amount of sheath-derived plaque material, which is increased in primary open angle glaucoma, was greatly increased in the subendothelial layer adjacent to Schlemm’s canal.

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Section: Introductionsupporting

confidence: 43%

Ultrastructural Changes in the Trabecular Meshwork of Juvenile Glaucoma

Furuyoshi

Furuyoshi²,

Futa³

et al. 1997

Ophthalmologica

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“…Congenital glaucoma is classified into three categories: primary congenital glaucoma (primary CG), glaucoma associated with congenital anomalies (associated glaucoma), and secondary glaucoma (SG) (Hoskins et al 1984). It is generally agreed that primary CG and associated glaucoma result from maldevelopment of the aqueous outflow system, and that SG results from damage to the aqueous outflow system caused by maldevelopment of some other ocular structure.…”

Section: Discussionsupporting

confidence: 40%

CHARGE association with congenital glaucoma due to maldevelopment of the anterior chamber angle

Katai

Urakawa

Sato

et al. 1997

Acta Ophthalmologica Scandinavica

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ABSTRACT.Purpose: We examined the clinicopathologic features of a male infant with the CHARGE association and bilateral congenital glaucoma. Methodc Trabeculectomy specimens were obtained from the anterior chamber angle and examined by light and electron microscopy. Results: Histopathologic examination of the trabeculectomy specimens showed immature development of the trabecular meshwork that was covered by the ciliary muscles. There were few intertrabecular spaces because the meshwork was almost completely filled with cells and extracellular substances. Deposition of a granular and/or homogeneous substance was observed in the subendothelial area of Schlemm's canal. Conclusions: Our patient exhibited features typical of the CHARGE association, but also had congenital glaucoma. We hypothesize that these clinical findings are all mediated by a neurocristopathic mechanism. Our findings suggest that the CHARGE association may predispose to anterior chamber angle maldevelopment, which can lead to congenital glaucoma.

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“…The management of glaucoma associated with SWS remains a difficult issue. Those patients that present at birth or during the first year of life are probably secondary to trabecular dysgenesis and are managed with trabeculotomy or goniotomy [3,4]. In older children, the cause of glaucoma is increased episcleral venous pressure, and if the intraocular pressure cannot be controlled with medications, the current approach consists of filtering procedures (trabeculectomy, nonpenetrating deep sclerectomy and tube-shunt surgery) [5][6][7].…”

Section: Introductionsupporting

confidence: 45%