Anatomical Confirmation of Computed Tomography-Based Diagnosis of the Atherosclerosis Discovered in 17th Century Korean Mummy

Kim, Myeung Ju; Kim, Yi Suk; Oh, Chang Seok; Go, Jai Hyang; Lee, In Sun; Park, Won Kyu; Cho, Seok Min; Kim, Soon Kwan; Shin, Dong Hoon

doi:10.1371/journal.pone.0119474

Cited by 26 publications

(14 citation statements)

References 46 publications

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“…2). By anatomical, histological, radiological and molecular investigations, signs of congenital or acquired diseases have been identifi ed [2,3,5,6,9,10,11,13]. Th e above-noted research techniques employed in collaborative research have driven the expansion of our understanding of Joseon societies to an unexpectedly high level.…”

Section: Introductionmentioning

confidence: 99%

Tracing the historical origin of Joseon mummies considering the structural similarities between the burial systems of Korean and Chinese dynasties

Kang

Hong

et al. 2017

PoA

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Joseon mummies have proved to be excellent subjects for scientific research on the health and disease statuses of pre-modern Korean peoples. Despite its academic significance, the origins of the Hoegwakmyo tomb in which the Joseon mummy was discovered have not yet been entirely revealed. Meanwhile, over the past several decades, there have been some reports on mummies and cultural artifacts preserved very well in the tombs of several Chinese dynasties (especially Song, Yuan, Ming and Qing). Although the Chinese tombs were very diverse in structure, we note that some graves among them were structurally very similar to Joseon Hoegwakmyo tombs. Before the Hoegwakmyo tomb in Korea, there were already similar tombs in China, inside which dead persons were mummified like the Joseon mummies. Considering that the Hoegwakmyo tomb of the Joseon Dynasty was established by the influence of the Confucian ideology, the Korean and Chinese mummies might share common cultural origins in history.

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Section: Introductionmentioning

confidence: 99%

Tracing the historical origin of Joseon mummies considering the structural similarities between the burial systems of Korean and Chinese dynasties

Kang

Hong

et al. 2017

PoA

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“…In particular, to assess whether atherosclerosis was a condition dependent on the lifestyle of Egyptian elites or if it was also encountered in ancient populations with different subsistence strategies (Allam et al, 2009(Allam et al, , 2011Thompson et al, 2013). Studies have demonstrated atherosclerosis in other prehistoric and historic mummies, including the chalcolithic Iceman, a mummy from the Joseon dynasty, and a pre-agricultural hunter-gatherer population from the Aleutian Islands (Murphy et al, 2003;Abdelfattah et al, 2013;Kim et al, 2015). While research seems to indicate that atherosclerosis is an inherent component of the aging process , it is undeniable that it some cases, such as the mummies from Vilnius, Lithuania, diet and behavior must have played a role (Piombino-Mascali et al, 2014).…”

Section: Discussionmentioning

confidence: 99%

Paleopathology in the Piraino mummies as illustrated by X-rays

Piombino‐Mascali

Zink

Panzer³

2017

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This paper presents the first radiological investigation of a collection of Sicilian mummies held in a crypt beneath the Mother Church of Piraino, Italy. The chamber contains 26 preserved bodies of religious dignitaries, either conserved vertically in special wall niches or horizontally on wooden shelves. The majority of bodies are clothed, and transportation outside of the crypt was not feasible. Therefore assessment of the remains via paleoradiological methods appeared to be the most convenient approach to investigate this precious ethno-anthropological heritage. Radiological examination of 23 of these mummies yielded information relating to their funerary treatment and some of the pathological alterations associated with the remains. These included osteoarthritis, diffuse idiopathic skeletal hyperostosis, and neoplasms, as well as any trauma present. These analyses provided insights into mortuary behavior and the osteobiographies of these clerical figures.

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“…It has been found in paleopathological studies of ancient and medieval mummies. The first finding of atherosclerosis confirmed by morphological evidence was made in Egyptian mummies thousands of years old at the beginning of the 20th century (Kim et al, 2015).…”

Section: Introductionmentioning

confidence: 92%

Research Article Polymorphisms of the genes eNOS, GSTT1 and GSTM1 are significantly associated with atherosclerotic disease in hypertensive patients

Moraes¹,

Silva²,

Lagares³

et al. 2019

Genet. Mol. Res.

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Atherosclerosis is a multifactorial chronic inflammatory disease that occurs in response to endothelial aggression. Systemic arterial hypertension is the main risk factor for the formation of atheromas, increasing the risk of cardiovascular diseases. Several genes are involved in atherogenesis and hypertension. We analyzed polymorphisms of candidate genes that potentially participate in processes related to this pathology, including G894T and T786C of eNOS, as well as GSTT1 and GSTM1 in 167 hypertensive patients and 100 controls. Blood samples were from patients attended at the Angiogenesis/Vascular Surgery and Cardiology Department of the Angiogyn clinic in Goiania. There was significant prevalence of the genotype GT (76%) and the mutant allele T (56%) of the T786C (eNOS) polymorphism in the patients. For the polymorphism T786C (eNOS), the heterozygote genotype (TC) was found in 58% of the samples; allele C was found in 61%, but there was no significant difference compared to controls. The ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 18 (1): gmr18089 M.P. Moraes et al. 2 GSTT1 genotype was found in 84% and GSTM1 was found in 73%; for both their predominance was significant. There are many possible explanations for how these polymorphisms affect the development of atherosclerosis and hypertension, but more studies are necessary for their elucidation.

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Anatomical Confirmation of Computed Tomography-Based Diagnosis of the Atherosclerosis Discovered in 17th Century Korean Mummy

Cited by 26 publications

References 46 publications

Tracing the historical origin of Joseon mummies considering the structural similarities between the burial systems of Korean and Chinese dynasties

Tracing the historical origin of Joseon mummies considering the structural similarities between the burial systems of Korean and Chinese dynasties

Paleopathology in the Piraino mummies as illustrated by X-rays

Research Article Polymorphisms of the genes <i>eNOS</i>, <i>GSTT1</i> and <i>GSTM1</i> are significantly associated with atherosclerotic disease in hypertensive patients

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