Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Lv, Dan; Ou, Yangpan; Chen, Yunhui; Ding, Zhenning; Ma, Jidong; Zhan, Chuang; Yang, Ru; Shang, Tinghuizi; Zhang, Guangfeng; Bai, Xiaoyu; Sun, Zimin; Xiao, Jian; Wang, Xiaoping; Guo, Wenbin; Li, Ping

doi:10.1186/s12888-022-04103-x

Cited by 5 publications

(1 citation statement)

References 58 publications

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“…The postcentral gyrus is an important brain region in the sensorimotor network, and neuroimaging studies have shown that obsessive–compulsive disorder is often associated with abnormal activity in this region ( 38 ). It has been observed that patients with OCD have reduced short-range positive functional connectivity (spFC) and long-range positive FC (lpFC) at rest and that the spFC of the left anterior central gyrus/posterior central gyrus can distinguish OCD patients from healthy controls ( 39 ). Le Jeune et al ( 40 ) performed 18-fluorodeoxyglucose positron emission tomography (PET) in 10 patients with OCD and found hypermetabolism in the postcentral gyrus in non-stimulated OCD patients compared with healthy controls.…”

Section: Discussionmentioning

confidence: 99%

Different degrees of nodes behind obsessive–compulsive symptoms of schizophrenia

Hu¹,

Xu²,

Li³

et al. 2023

Front. Psychiatry

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Obsessive–compulsive symptoms are frequently observed in various psychiatric disorders, including obsessive–compulsive disorder, schizophrenia, depression, and anxiety. However, the underlying anatomical basis of these symptoms remains unclear. In this study, we aimed to investigate the mechanism of schizophrenia with obsessive–compulsive symptoms by using diffusion tensor imaging (DTI)-based structural brain connectivity analysis to assess the network differences between patients with obsessive–compulsive disorder (OCD), patients with schizophrenia showing obsessive–compulsive symptoms (SCH), schizophrenia patients with obsessive–compulsive symptoms due to clozapine (LDP), and healthy controls (CN). We included 21 patients with OCD, 20 patients with SCH, 12 patients with LDP, and 25 CN. All subjects underwent MRI scanning, and structural brain connections were estimated using diffusion tensor imaging for further analysis of brain connectivity. The topology and efficiency of the network and the characteristics of various brain regions were investigated. We assessed baseline YALE-BROWN OBSESSIVE COMPULSIVE SCALE (Y-BOCS), Positive and Negative Syndrome Scale (PANSS), and 24-item Hamilton Depression Scale (HAMD-24) scores. Our results showed significant differences among the SCH, OCD, and CN groups (p < 0.05) in the MRI-measured degree of the following nodes: the superior orbitofrontal gyrus (25Frontal_Med_Orb_L), lingual gyrus (47Lingual_L), postcentral gyrus (58Postcentral_R), and inferior temporal gyrus (90Temporal_Inf_R). Additionally, we found significant differences in the degree of the brain regions 02Precentral_R, 47Lingual_L, 58Postcentral_R, and 90Temporal_Inf_R between the CN, OCD, SCH, and LDP groups (p < 0.05). These findings suggest that alterations in the degree of nodes might be the mechanism behind obsessive–compulsive symptoms in schizophrenia.

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Section: Discussionmentioning

confidence: 99%

Different degrees of nodes behind obsessive–compulsive symptoms of schizophrenia

Hu¹,

Xu²,

Li³

et al. 2023

Front. Psychiatry

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Rich Club Reorganization in Nurses Before and After the Onset of Occupational Burnout: A Longitudinal MRI Study

Chen,

Su,

Zhao

et al. 2024

Magnetic Resonance Imaging

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BackgroundStudies on potential disruptions in rich club structure in nursing staff with occupational burnout are lacking. Moreover, existing studies on nurses with burnout are limited by their cross‐sectional design.PurposeTo investigate rich club reorganization in nursing staff before and after the onset of burnout and the underlying impact of anatomical distance on such reconfiguration.Study TypeProspective, longitudinal.PopulationThirty‐nine hospital nurses ( years old at baseline, years old at a follow‐up within 1.5 years, 38 female).Field Strength/SequenceMagnetization‐prepared rapid gradient‐echo and gradient‐echo echo‐planar imaging sequences at 3.0 T.AssessmentThe Maslach Burnout Inventory and Symptom Check‐List 90 testing were acquired at each MRI scan. Rich club structure was assessed at baseline and follow‐up to determine whether longitudinal changes were related to burnout and to changes in connectivities with different anatomical distances (short‐, mid‐, and long range).Statistical TestsChi‐square, paired‐samples t, two‐sample t, Mann–Whitney U tests, network‐based statistic, Spearman correlation analysis, and partial least squares regression analysis. Significance level: Bonferroni‐corrected .ResultsIn nurses who developed burnout: 1) Strengths of rich club, feeder, local, short‐, mid‐, and long‐range connectivities were significantly decreased at follow‐up compared with baseline. 2) At follow‐up, strengths of above connectivities and that between A5m.R and dlPu.L were significantly correlated with emotional exhaustion (r ranges from −0.57 to −0.73) and anxiety scores (r = −0.56), respectively. 3) Longitudinal change (follow‐up minus baseline) in connectivity strength between A5m.R and dlPu.L reflected change in emotional exhaustion score (r = 0.87). Longitudinal changes in strength of connectivities mainly involving parietal lobe were significantly decreased in nurses who developed burnout compared with those who did not.Data ConclusionIn nurses after the onset of burnout, rich club reorganization corresponded to significant reductions in strength of connectivities with different anatomical distances.Level of Evidence1Technical EfficacyStage 2

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Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies

Perera,

Gotsis,

Bailey

et al. 2024

Cerebral Cortex

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Obsessive-compulsive disorder (OCD) is a debilitating psychiatric condition that is difficult to treat due to our limited understanding of its pathophysiology. Functional connectivity in brain networks, as evaluated through neuroimaging studies, plays a pivotal role in understanding OCD. While both electroencephalography (EEG) and functional magnetic resonance imaging (fMRI) have been extensively employed in OCD research, few have fully synthesized their findings. To bridge this gap, we reviewed 166 studies (10 EEG, 156 fMRI) published up to December 2023. In EEG studies, OCD exhibited lower connectivity in delta and alpha bands, with inconsistent findings in other frequency bands. Resting-state fMRI studies reported conflicting connectivity patterns within the default mode network (DMN) and sensorimotor cortico-striato-thalamo-cortical (CSTC) circuitry. Many studies observed decreased resting-state connectivity between the DMN and salience network (SN), implicating the 'triple network model' in OCD. Task-related hyperconnectivity within the DMN-SN and hypoconnectivity between the SN and frontoparietal network suggest OCD-related cognitive inflexibility, potentially due to triple network dysfunction. In conclusion, our review highlights diverse connectivity differences in OCD, revealing complex brain network interplay that contributes to symptom manifestation. However, the presence of conflicting findings underscores the necessity for targeted research to achieve a comprehensive understanding of the pathophysiology of OCD.

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Anatomical distance affects functional connectivity at rest in medicine-free obsessive–compulsive disorder

Cited by 5 publications

References 58 publications

Different degrees of nodes behind obsessive–compulsive symptoms of schizophrenia

Different degrees of nodes behind obsessive–compulsive symptoms of schizophrenia

Rich Club Reorganization in Nurses Before and After the Onset of Occupational Burnout: A Longitudinal MRI Study

Exploring functional connectivity in large-scale brain networks in obsessive-compulsive disorder: a systematic review of EEG and fMRI studies

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