Anatomical variations of the dentate gyrus in normal adult brain

Haładaj, Robert

doi:10.1007/s00276-019-02298-5

Cited by 9 publications

(7 citation statements)

References 25 publications

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“…We chose to retain these categorical descriptions while changing the language to "well-de ned", "moderately de ned", and "illde ned". While previous results found that 67.5% were well-developed, 22.5% were underdeveloped, and 10% were hypoplastic, we found that 36% were well-de ned, 51% were moderately de ned, and 13% were ill-de ned [7]. Both ndings indicate that there is in fact variation in the qualitative scoring of the dentate gyrus, but there are some differences in the speci c results (e.g.…”

Section: Discussioncontrasting

confidence: 90%

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A Cadaveric Study of Anatomical Variations in the Limbic System

Nation

Morgan

2023

Preprint

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PURPOSE The limbic system is a collection of brain structures responsible for affective processing, spatial coding, and certain types of memory. A comprehensive investigation of numerous limbic system components is necessary to thoroughly understand anatomical and pathological differences in individuals with related disorders (e.g., Alzheimer’s, depression, etc.). This study examines anatomical variations of limbic system structures including the hippocampus, dentate gyrus, amygdala, and cingulate gyrus.METHODS This cadaveric study includes the dissection of 47 formalin-fixed brain hemispheres and measurements of pertinent structures. The dentate gyrus, hippocampus, and amygdala were given categorical results: ill-defined, moderately defined, and well-defined; additionally, quantitative measurements were taken for all structures.RESULTS Our results indicate variations in the classification of the dentate gyrus (36% well-defined, 51% moderately defined, and 13% ill-defined) and amygdala (58% well-defined, 40% moderately defined, and 2% ill-defined). All hippocampus samples were well-defined (100%).CONCLUSION The knowledge of typical anatomy and morphology furthers our understanding of the limbic system and could be used to better understand clinical presentations. Future studies may be able to link anatomical variations and any potential relationships reported in this study to observed behavior. In summary, a thorough understanding of these variations will be useful for diagnostic purposes and future research.

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Section: Discussioncontrasting

confidence: 90%

“…One potential cause for this could be the hemispheres utilized. Haladaj reported the use of forty hemispheres but did not indicate if those were left, right, or both sides [7]. Given that this study utilized both this could be a potential cause for varying results.…”

Section: Discussionmentioning

confidence: 91%

A Cadaveric Study of Anatomical Variations in the Limbic System

Nation

Morgan

2023

Preprint

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“…If the goal is to postulate about the function of specific brain regions, inferring the sought activity requires knowledge about the underlying brain structures and the exact electrode locations. However, subject brain and general anatomical characteristics present a significant variability (Bartley et al, 1997 ; Yang et al, 2019 ; Haładaj, 2020 ). Individual head shapes also cause differences in the relative placement and studies show that the considered electrode locations can greatly affect analyses results (Schwartz et al, 1996 ; Van Hoey et al, 2000 ; Wang and Gotman, 2001 ; Dalal et al, 2014 ; Hirth et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of individualized brain anatomies and EEG electrode positions on inferred activity of the primary auditory cortex

Ignatiadis

Barumerli

Tóth

et al. 2022

Front. Neuroinform.

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Due to its high temporal resolution and non-invasive nature, electroencephalography (EEG) is considered a method of great value for the field of auditory cognitive neuroscience. In performing source space analyses, localization accuracy poses a bottleneck, which precise forward models based on individualized attributes such as subject anatomy or electrode locations aim to overcome. Yet acquiring anatomical images or localizing EEG electrodes requires significant additional funds and processing time, making it an oftentimes inaccessible asset. Neuroscientific software offers template solutions, on which analyses can be based. For localizing the source of auditory evoked responses, we here compared the results of employing such template anatomies and electrode positions versus the subject-specific ones, as well as combinations of the two. All considered cases represented approaches commonly used in electrophysiological studies. We considered differences between two commonly used inverse solutions (dSPM, sLORETA) and targeted the primary auditory cortex; a notoriously small cortical region that is located within the lateral sulcus, thus particularly prone to errors in localization. Through systematical comparison of early evoked component metrics and spatial leakage, we assessed how the individualization steps impacted the analyses outcomes. Both electrode locations as well as subject anatomies were found to have an effect, which though varied based on the configuration considered. When comparing the inverse solutions, we moreover found that dSPM more consistently benefited from individualization of subject morphologies compared to sLORETA, suggesting it to be the better choice for auditory cortex localization.

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“…If the goal is to postulate about the function of specific brain regions, inferring the sought activity requires knowledge about the underlying brain structures and the exact electrode locations. However, subject brain and general anatomical characteristics present a significant variability (Haładaj, 2020; Yang et al, 2019; Bartley et al, 1997). Individual head shapes also cause differences in the relative placement and studies show that the considered electrode locations can greatly affect analyses results (Hirth et al, 2020; Van Hoey et al, 2000; Wang and Gotman, 2001; Dalal et al, 2014; Schwartz et al, 1996).…”

Section: Introductionmentioning

confidence: 99%

Benefits of individualized brain anatomies and EEG electrode positions for auditory cortex localization

Ignatiadis

Barumerli

Tóth

et al. 2022

Preprint

View full text Add to dashboard Cite

Due to its high temporal resolution and non-invasive nature, electroencephalography (EEG) is considered a method of great value for the field of auditory cognitive neuroscience. In performing source space analyses, localization accuracy poses a bottleneck, which precise forward models based on individualized attributes such as subject anatomy or electrode locations aim to overcome. Yet acquiring anatomical images or localizing EEG electrodes requires significant additional funds and processing time, making it an oftentimes inaccessible asset. Neuroscientific software offers template solutions, on which analyses can be based. For localizing the source of auditory evoked responses, we here compared the results of employing such template anatomies and electrode positions versus the subject-specific ones, as well as combinations of the two. All considered cases represented approaches commonly used in electrophysiological studies. We considered differences between two commonly used inverse solutions (dSPM, sLORETA) and targeted the primary auditory cortex; a notoriously small cortical region that is located within the lateral sulcus, thus more prone to errors in localization. Through systematical comparison of the outcomes in terms of auditory activity attributes and leakage quantification, we assessed how the individualization steps impacted the analyses outcomes. Both electrode locations as well as subject anatomies were found to have an effect, which though varied based on the configuration considered. When comparing the inverse solutions, we moreover found that dSPM more consistently benefited from individualization of subject characteristics. Based on the scientific question considered, our results may be used to facilitate the planning of auditory neuroscientific experiments in terms of expected infrastructure, personnel and funds.

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Anatomical variations of the dentate gyrus in normal adult brain

Cited by 9 publications

References 25 publications

A Cadaveric Study of Anatomical Variations in the Limbic System

A Cadaveric Study of Anatomical Variations in the Limbic System

Effects of individualized brain anatomies and EEG electrode positions on inferred activity of the primary auditory cortex

Benefits of individualized brain anatomies and EEG electrode positions for auditory cortex localization

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