Anatomically based targeting of prefrontal cortex for rTMS

Herbsman, Tal; Nahas, Ziad

doi:10.1016/j.brs.2011.01.004

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…Heterogeneous effects of NIBS on the DLPFC on working memory performance might be explained by a variability of NIBS parameters and also by individual differences, such as anatomical variability (15). In terms of the former, individual anatomical brain biomarkers, including cortical volume and cortical thickness, were, respectively, found to be related to NIBS response in depression (16,17) and for tDCS in decision-making processes (18). Some studies with rTMS also showed that changes in longitudinal cortical thickness are associated with rTMS responders in depression (19).…”

Section: Introductionmentioning

confidence: 99%

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Razza,

Vanderhasselt,

Luethi

et al. 2023

Braz J Med Biol Res

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Non-invasive brain stimulation (NIBS) probing the dorsolateral prefrontal cortex (DLPFC) has been shown to have little effect on working memory. The variability of NIBS responses might be explained by inter-subject brain anatomical variability. We investigated whether baseline cortical brain thickness of regions of interest was associated with working memory performance after NIBS by performing a secondary analysis of previously published research. Structural magnetic resonance imaging data were analyzed from healthy subjects who received transcranial direct current stimulation (tDCS), intermittent theta-burst stimulation (iTBS), and placebo. Twenty-two participants were randomly assigned to receive all the interventions in a random order. The working memory task was conducted after the end of each NIBS session. Regions of interest were the bilateral DLPFC, medial prefrontal cortex, and posterior cingulate cortex. Overall, 66 NIBS sessions were performed. Findings revealed a negative significant association between cortical thickness of the bilateral dorsolateral prefrontal cortex and reaction time for both tDCS (left: P=0.045, right: P=0.037) and iTBS (left: P=0.007, right: P=0.007) compared to placebo. A significant positive association was found for iTBS and posterior cingulate cortex (P=0.03). No association was found for accuracy. Our findings provide the first evidence that individual cortical thickness of healthy subjects might be associated with working memory performance following different NIBS interventions. Therefore, cortical thickness could explain - to some extent - the heterogeneous effects of NIBS probing the DLPFC.

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Section: Introductionmentioning

confidence: 99%

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Razza,

Vanderhasselt,

Luethi

et al. 2023

Braz J Med Biol Res

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“…This may lead to suboptimal clinical responses when compared to individualized targeting techniques based on structural brain scanning. Research and clinical studies require accuracy and precision not offered by these probabilistic targeting methods (Herbsman and Nahas 2011). For example, a common and easy method for the positioning of the coil in psychiatric therapies uses the standardized T3P3 site according to the International 10-20 system of EEG electrode positioning (Jasper 1958).…”

Section: Introductionmentioning

confidence: 99%

GeodesicSlicer: a Slicer Toolbox for Targeting Brain Stimulation

et al. 2020

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NonInvasive Brain Stimulation (NIBS) is a potential therapeutic tool with growing interest, but neuronavigation-guided software and tools available for the target determination are mostly either expensive or closed proprietary applications. To address these limitations, we propose GeodesicSlicer, a customizable, free, and open-source NIBS therapy research toolkit. GeodesicSlicer is implemented as an extension for the widely used 3D Slicer medical image visualization and analysis application platform. GeodesicSlicer uses cortical stimulation target from either functional or anatomical images to provide functionality specifically designed for NIBS therapy research. The provided algorithms are tested and they are accessible through a convenient graphical user interface. Modules have been created for NIBS target determination according to the position of the electrodes in the 10-20 system electroencephalogram and calculating correction factors to adjust the repetitive Transcranial Magnetic Stimulation (rTMS) dose for the treatment. Two illustrative examples are processing with the module. This new open-source software has been developed for NIBS therapy: GeodesicSlicer is an alternative for laboratories that do not have access to neuronavigation system. The triangulation-based MRI-guided method presented here provides a reproducible and inexpensive way to position the TMS coil that may be used without the use of a neuronavigation system.

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“…One way is to take into account the anatomical variability since previous reports have shown that the effects of the stimulation are proportional to the distance from the stimulation to the target (Cohen et al, 1990;Fadini et al, 2009). However, most clinical applications are based on standardized targeting methods that do not take into account for individual anatomy, which can contribute to suboptimal clinical responses compared to other methods such as personalized targeting techniques based on individual brain imaging (Herbsman and Nahas, 2011).…”

Section: Introductionmentioning

confidence: 99%

A new toolbox to compare target localizations for non-invasive brain stimulation: An application of rTMS treatment for auditory hallucinations in schizophrenia

Briend

Nathou

Delcroix

et al. 2020

Schizophrenia Research

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Background: Most repetitive transcranial magnetic stimulation (rTMS) studies aiming to reduce auditory verbal hallucinations (AVH) in schizophrenia target the left temporo-parietal junction (TPJ), but the efficacy of this approach remains controversial. The observed differences in efficacy could be attributed to inaccurate target localization. Here, to precisely quantify anatomical bias induced by localization method, we developed a free open-source software (GeodesicSlicer) that computes shortest curved path (i.e. geodesic) between rTMS targets. Here we compare a personalized target with accurate anatomical criteria with a standardized target based on the 10-20 EEG system (the middle between T3 and P3 electrodes: T3P3). Methods: We compare in 69 patients with schizophrenia the geodesic distances of two approaches for rTMS target localization within the left TPJ. In addition, we characterize the personalized target according to the 10-20 EEG system. Results: A differential of 3 cm in term of geodesic distance between rTMS localization approaches was observed. Moreover, this personalized target to treat AVH is located at 25% in the T3-P3 axis. Conclusions: This software for rTMS localization comparison demonstrates the difference between standardized and personalized rTMS target. This difference has the potential to explain a part of the dissonant clinical results found in previous rTMS studies.

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Anatomically based targeting of prefrontal cortex for rTMS

Cited by 6 publications

References 12 publications

Cortical thickness is related to working memory performance after non-invasive brain stimulation

Cortical thickness is related to working memory performance after non-invasive brain stimulation

GeodesicSlicer: a Slicer Toolbox for Targeting Brain Stimulation

A new toolbox to compare target localizations for non-invasive brain stimulation: An application of rTMS treatment for auditory hallucinations in schizophrenia

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