Anatomische Beiträge zur Lehre von der Pickschen umschriebenen Großhirnrinden-Atrophie („Picksche Krankheit“)

Onari, K.; Spatz, H.

doi:10.1007/978-3-642-49740-7_24

Cited by 50 publications

(48 citation statements)

References 2 publications

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“…Additional examples of frontal and/or temporal cortical atrophy with or without argyrophilic inclusions were subsequently reported and the clinical condition was called "Pick's disease" (Onari and Spatz 1926;Stertz 1926). Unlike Pick, who believed to have described atypical forms of senile dementia, Onari and Spatz considered Pick's disease to be a distinct entity.…”

Section: The Concept Of Frontotemporal Dementia: Historical Overviewmentioning

confidence: 99%

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Goedert¹,

Ghetti²,

Spillantini³

2011

Cold Spring Harbor Perspectives in Medicine

138

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Section: The Concept Of Frontotemporal Dementia: Historical Overviewmentioning

confidence: 99%

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Goedert¹,

Ghetti²,

Spillantini³

2011

Cold Spring Harbor Perspectives in Medicine

138

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“…1 The international consensus criteria for FTLD describe 3 clinical subtypes: frontotemporal dementia (FTD), progressive nonfluent aphasia (PNFA), and semantic dementia (SD), believed to result from characteristic patterns of cortical atrophy. 2 FTD is characterized by early changes in personality and comportment, whereas aphasia is absent at onset.…”

mentioning

confidence: 99%

Cortical Morphometric Subclassification of Frontotemporal Lobar Degeneration

Lindberg¹,

Östberg²,

Zandbelt³

et al. 2009

AJNR Am J Neuroradiol

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BACKGROUND AND PURPOSE:Frontotemporal lobar degeneration (FTLD) is a primary neurodegenerative disease comprising 3 clinical subtypes: frontotemporal dementia (FTD), semantic dementia (SD), and progressive nonfluent aphasia (PNFA). The subdivision is primarily based on the characteristic clinical symptoms displayed by each subtype. We hypothesized that these symptoms would be correlated to characteristic patterns of brain atrophy, which could be indentified and used for subclassification of subjects with FTLD.

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“…In 1911, Alzheimer [1] found the presence of argyrophilic inclusions (Pick bodies, PB) and ballooned neurons (Pick cells, PC) in the brain in such cases. Onari and Spatz [23] defined PD as a disease entity in 1926, although the presence or absence of PB and PC was not declared in the diagnostic criteria of PD. Constantinidis et al [3] divided cases with lobar atrophy into three groups; group A with PB and PC in the atrophied cortex, group B with PC but without PB, and group C without PB and PC.…”

Section: Introductionmentioning

confidence: 99%

Clinicopathological Study of Two Subtypes of Pick’s Disease in Japan

Odawara

Iseki²,

Kanai³

et al. 2002

Dement Geriatr Cogn Disord

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We examined the clinical and neuropathological findings in 3 cases of Pick’s disease with Pick bodies (PiD) and 7 cases of atypical Pick’s disease without Pick bodies (aPiD). PiD and aPiD cases corresponded clinically to frontotemporal dementia and semantic dementia, respectively, based on the clinical diagnostic criteria of frontotemporal lobar degeneration. Brain CT showed that cerebral atrophy was accentuated at an early stage of the illness in the anterior portion of the frontal lobes in PiD cases and in the anterior portion of the temporal lobes in aPiD cases. Neuropathologically, PiD cases showed more circumscribed lobar atrophy than aPiD cases. Both PiD and aPiD cases revealed moderate to severe degeneration with neuronal loss and gliosis in the affected cerebral cortex and subcortical nuclei, but only aPiD cases had pyramidal tract degeneration. Immunohistochemical analyses demonstrated that tauopathy with phosphorylated tau accumulation in the Pick bodies in PiD cases, while aPiD cases showed ubiquitinopathy with ubiquitin accumulation in the intraneuronal and dendritic inclusions. These findings suggested that two subtypes of Pick’s disease in Japan can be distinguished not only neuropathologically but also clinically based on differences in pathogenesis.

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Anatomische Beiträge zur Lehre von der Pickschen umschriebenen Großhirnrinden-Atrophie („Picksche Krankheit“)

Cited by 50 publications

References 2 publications

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Frontotemporal Dementia: Implications for Understanding Alzheimer Disease

Cortical Morphometric Subclassification of Frontotemporal Lobar Degeneration

Clinicopathological Study of Two Subtypes of Pick’s Disease in Japan

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