Anatomy and Pathology of the Placental Membranes

Cohen, Marta C.; Scheimberg, Irene; Hutchinson, J. Ciaran

doi:10.1007/978-3-030-84725-8_15

Cited by 2 publications

(3 citation statements)

References 429 publications

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“…p38 is expressed during the development of the fetal membrane (amniochorionic membranes) that lines the intrauterine cavity and which is constantly bathed in the amniotic fluid [ 10 , 11 , 13 , 15 ]. Fetal membranes’ structural and mechanical stability and antimicrobial properties are essential for fetal growth and pregnancy maintenance [ 13 , 16 ]. The pregnant uterine cavity experiences distinct oxidative environments at different trimesters where locally generated and tightly regulated ROS helps tissue growth and remodeling that is enabled by p38 [ 10 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

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Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

et al. 2022

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Oxidative stress (OS) induced activation of p38 mitogen-activated kinase (MAPK) and cell fate from p38 signaling was tested using the human fetal membrane’s amnion epithelial cells (AEC). We created p38 KO AEC using the CRISPR/Cas9 approach and tested cell fate in response to OS on an AEC-free fetal membrane extracellular matrix (ECM). Screening using image CyTOF indicated OS causing epithelial-mesenchymal transition (EMT). Further testing revealed p38 deficiency prevented AEC senescence, EMT, cell migration, and inflammation. To functionally validate in vitro findings, fetal membrane-specific conditional KO (cKO) mice were developed by injecting Cre-recombinase encoded exosomes intra-amniotically into p38αloxP/loxP mice. Amnion membranes from p38 cKO mice had reduced senescence, EMT, and increased anti-inflammatory IL-10 compared to WT animals. Our study suggested that overwhelming activation of p38 in response to OS inducing risk exposures can have an adverse impact on cells, cause cell invasion, inflammation, and ECM degradation detrimental to tissue homeostasis.

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Section: Introductionmentioning

confidence: 99%

“…Structurally, the AEC layer is attached to the collagen-rich extracellular matrix (ECM) region via Type IV collagen-rich basement membranes [ 16 ]. Transitioned AEC comprise the major population of amnion mesenchymal cells (AMC) that complete the ECM scaffold.…”

Section: Introductionmentioning

confidence: 99%

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

et al. 2022

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“…Macroscopically, the amnion is a thin layer (only 20% of the thickness of the fetal membranes) and is a transparent (translucent) structure. This amniotic membrane can easily be separated from the underlying chorion because the amnion is never completely fused with the chorion and is only passively attached by internal pressure from the amniotic fluid [15]. The amnion lacks blood vessels and obtains its required nutrients and oxygen supplied directly by diffusion from the surrounding amniotic fluid, fetal surface vessels, or the decidua [16].…”

Section: Literature Reviewmentioning

confidence: 99%

Relationship between Premature Rupture of the Membrane and Cesarean Delivery: Case from Jakarta, Indonesia

Sihombing

Miqbel

Sirait

2023

AJRID

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Premature rupture of membranes (PROM) is the spontaneous rupture of the membranes before the onset of signs of labor. It can occur both before term (<37 weeks) and after term (> 37 weeks). Caesarean delivery is a surgical technique to deliver the fetus through an incision in the abdominal wall and uterine wall. This procedure is performed to minimize all complications from premature rupture of membranes. This study aims to determine the relationship between premature rupture of membranes and delivery of sectio caesarea at the UKI General Hospital in the 2019 period by using a descriptive content analysis method (analysis of medical records documents) with a cross-sectional approach and obtained 65 samples who experienced premature rupture of membranes. The results showed that 53 samples (81.55%) experienced premature rupture of membranes and performed sectio caesarea, while 12 samples (18.45%) had premature rupture of membranes but did not perform sectio caesarea with p-value = 0.001 (p <0.05) from the results of the chi-square statistical test. From the results of the analysis, it was found that there was a relationship between premature rupture of membranes and delivery of cesarean section at the UKI General Hospital for the 2019 period. It is suggested that patients avoid the factors that can cause premature rupture of the membranes, which have been told by the doctor or health worker and the patient's family to support the patient to remind them to avoid factors that can cause premature rupture of the membranes.

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Anatomy and Pathology of the Placental Membranes

Cited by 2 publications

References 429 publications

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

Stress signaler p38 mitogen-activated kinase activation: a cause for concern?

Relationship between Premature Rupture of the Membrane and Cesarean Delivery: Case from Jakarta, Indonesia

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