Anatomy and physiology of the reproductive system

Szmelskyj, Irina

doi:10.1016/b978-0-7020-5010-7.00002-3

Cited by 7 publications

(6 citation statements)

References 45 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, the friction between the normal sperm models and the internal wall increases and decelerates the velocity of the normal sperm models toward the ovary. Our study thus confirms the results of previous studies in this field about the defects in function and selection ability of the human fallopian tube due to women’s aging ( Pinero and Foraker, 1963 ; Bouyer et al, 2003 ; Maheshwari et al, 2008 ; Briceag et al, 2015 ; Szmelskyj et al, 2015 ).…”

Section: Discussionsupporting

confidence: 92%

“…This region includes finger-like fimbria, which catch the released oocyte from the ovary during each menstrual cycle ( Vue et al, 2018 ; Winuthayanon and Li, 2018 ; Narang et al, 2019 ). The fallopian tube length averages 10–12 cm and has a lumen diameter of less than 1 mm ( Han et al, 2013 ; Szmelskyj, 2015 ; Narang et al, 2019 ). The wall of the fallopian tube is particularly composed of a mucosal layer.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Evaluation of women’s aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling

Nassir,

Levi,

Wiser

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The fallopian tubes play an important role in human fertility by facilitating the spermatozoa passage to the oocyte as well as later actively facilitating the fertilized oocyte transportation to the uterus cavity. The fallopian tubes undergo changes involving biological, physical, and morphological processes due to women aging, which may impair fertility. Here, we have modelled fallopian tubes of women at different ages and evaluated the chances of normal and pathological sperm cells reaching the fertilization site, the ampulla. For this purpose, we present a dynamic three-dimensional (3D) mechanical model of human sperm cells swimming through the human fallopian tube for different women’s age groups. By utilizing a unique combination of simulative tools, we implemented dynamic 3D detailed geometrical models of many normal and pathological sperm cells swimming together in 3D geometrical models of three fallopian tubes describing different women’s age groups. By tracking the sperm cell swim, we found that for all age groups, the quantity of normal sperm cells in the ampulla is the highest, compared with the pathological sperm cells. On the other hand, the number of normal sperm cells in the fertilization site decreases due to the morphological and mechanical changes that occur in the fallopian tube with age. Moreover, in older ages, the normal sperm cells swim with lower velocities and for shorter distances inside the ampulla toward the ovary. Thus, the changes that the human fallopian tube undergoes due to women’s aging have a significant influence on the human sperm cell motility. Our model of sperm cell motility through the fallopian tube in relation to the woman’s age morphological changes provides a new scope for the investigation and treatment of diseases and infertility cases associated with aging, as well as a potential personalized medicine tool for evaluating the chances of a natural fertilization per specific features of the man’s sperm and the woman’s reproductive system.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Evaluation of women’s aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling

Nassir,

Levi,

Wiser

et al. 2024

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…The mechanisms underlying follicular quiescence and maintenance of oocyte viability are still poorly understood [11,29]. After birth, only approximately 1 million oocytes survive the process of follicle degeneration, commonly known as atresia [30]. Since the process of atresia continues during growth and adulthood, at puberty there are only Fig.…”

Section: Homo Sapiensmentioning

confidence: 99%

Oogenesis Signaling from Development to Environmental Plasticity and Aging

Marques

Matos

Martinho

2020

Tissue-Specific Cell Signaling

View full text Add to dashboard Cite

Oogenesis is a unique process of cell division and differentiation, where a mature oocyte is formed from a germ cell precursor. In this chapter, the complex regulatory network responsible for oocyte differentiation and maturation in Drosophila melanogaster and human female gametogenesis is discussed. There is a focus in the hormonal and non-hormonal signaling pathways responsible for the communication between the oocyte and the surrounding somatic cells, with a special emphasis to starvation-dependent and age-dependent loss of female fertility.

show abstract

“…The entire ovarian reserve of oocytes is produced during fetal development [88,89]. A human female has 14 million oocytes at 20 weeks of gestation, but this number will decline during the female s life [81,89,90]. At the time of birth, the ovary contains ~1-2 million oocytes; at puberty, this number drops to ~300,000, and at menopause, the ovary has < 100 oocytes [81,89,[91][92][93][94][95].…”

Section: Female Reproductionmentioning

confidence: 99%

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction

González-Alvarez,

Antwi-Boasiako,

Keating

2024

Toxics

View full text Add to dashboard Cite

Per- and poly-fluoroalkylated substances (PFAS) are a large group of chemicals that persist both in the environment and in the body. Legacy PFAS, e.g., perfluorooctanoic acid and perfluorooctane sulfonic acid, are implicated as endocrine disruptors and reproductive and developmental toxicants in epidemiological and animal model studies. This review describes female reproductive outcomes of reported studies and includes where associative relationships between PFAS exposures and female reproductive outcomes have been observed as well as where those are absent. In animal models, studies in which PFAS are documented to cause toxicity and where effects are lacking are described. Discrepancies exist in both human and animal studies and are likely attributable to human geographical contamination, developmental status, duration of exposure, and PFAS chemical identity. Similarly, in animal investigations, the model used, exposure paradigm, and developmental status of the female are important and vary widely in documented studies. Taken together, support for PFAS as reproductive and developmental toxicants exists, although the disparity in study conditions and human exposures contribute to the variation in effects noted.

show abstract

Anatomy and physiology of the reproductive system

Cited by 7 publications

References 45 publications

Evaluation of women’s aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling

Evaluation of women’s aging influence on sperm passage inside the fallopian tube using 3D dynamic mechanical modeling

Oogenesis Signaling from Development to Environmental Plasticity and Aging

Effects of Per- and Polyfluoroalkylated Substances on Female Reproduction

Contact Info

Product

Resources

About