Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

Takemura, Hiromasa; Palomero‐Gallagher, Nicola; Axer, Markus; Gräßel, David; Jorgensen, Matthew J.; Woods, Roger P.; Zilles, Karl

doi:10.7554/elife.55444

Cited by 27 publications

(22 citation statements)

References 160 publications

(318 reference statements)

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“…Area V1 is the cytoarchitectonically most differentiated isocortical area in the primate brain, with a unique sublamination of layer IV (Zilles et al 2015b). This cytoarchitectonic uniqueness is mirrored by its receptor architecture, which clearly reveals the border to V2, as revealed not only in the macaque (present results;Hendry et al 1990;Rakic et al 1988;Rakic and Lidow 1995;Rosier et al 1991;Zilles and Clarke 1997;Zilles and Palomero-Gallagher 2017a) but also in the vervet brain (Takemura et al 2020).…”

Section: Receptor Architectonic Subdivisions Of Cytoarchitectonically Identified Visual Areas In the Macaque Brainsupporting

confidence: 67%

Receptor architecture of macaque and human early visual areas: not equal, but comparable

et al. 2021

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Existing cytoarchitectonic maps of the human and macaque posterior occipital cortex differ in the number of areas they display, thus hampering identification of homolog structures. We applied quantitative in vitro receptor autoradiography to characterize the receptor architecture of the primary visual and early extrastriate cortex in macaque and human brains, using previously published cytoarchitectonic criteria as starting point of our analysis. We identified 8 receptor architectonically distinct areas in the macaque brain (mV1d, mV1v, mV2d, mV2v, mV3d, mV3v, mV3A, mV4v), and their respective counterpart areas in the human brain (hV1d, hV1v, hV2d, hV2v, hV3d, hV3v, hV3A, hV4v). Mean densities of 14 neurotransmitter receptors were quantified in each area, and ensuing receptor fingerprints used for multivariate analyses. The 1st principal component segregated macaque and human early visual areas differ. However, the 2nd principal component showed that within each species, area-specific differences in receptor fingerprints were associated with the hierarchical processing level of each area. Subdivisions of V2 and V3 were found to cluster together in both species and were segregated from subdivisions of V1 and from V4v. Thus, comparative studies like this provide valuable architectonic insights into how differences in underlying microstructure impact evolutionary changes in functional processing of the primate brain and, at the same time, provide strong arguments for use of macaque monkey brain as a suitable animal model for translational studies.

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Section: Receptor Architectonic Subdivisions Of Cytoarchitectonically Identified Visual Areas In the Macaque Brainsupporting

confidence: 67%

Receptor architecture of macaque and human early visual areas: not equal, but comparable

et al. 2021

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“…The use of PLI to image brain tissue has been demonstrated in human (Axer et al, 2011a,b; Caspers et al, 2015; Mollink et al, 2017; Zeineh et al, 2017; Henssen et al, 2019), seal (Dohmen et al, 2015), rat (Schubert et al, 2016, 2018), pigeon (Herold et al, 2018; Stacho et al, 2020), and vervet monkey (Takemura et al, 2020). Examples of the detailed visualizations of cortical and white-matter fiber architecture that can be achieved by PLI are shown in Fig.…”

Section: Validation Of Fiber Orientationsmentioning

confidence: 99%

Post mortem mapping of connectional anatomy for the validation of diffusion MRI

Yendiki

Axer

Howard

et al. 2021

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Despite the impressive advances in diffusion MRI (dMRI) acquisition and analysis that have taken place during the Human Connectome era, dMRI tractography is still an imperfect source of information on the circuitry of the brain. In this review, we discuss methods for post mortem validation of dMRI tractography, fiber orientations, and other microstructural properties of axon bundles that are typically extracted from dMRI data. These methods include anatomic tracer studies, Klingler's dissection, myelin stains, label-free optical imaging techniques, and others. We provide an overview of the basic principles of each technique, its limitations, and what it has taught us so far about the accuracy of different dMRI acquisition and analysis approaches.

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“…The Dejerines themselves remarked on the limits of even masterful brain dissection skills for identification of terminations in pathway-dense regions, limiting the extent of guidance that postmortem dissections can provide. The continuous improvement in MRI tractography angular resolution, and the development of alternative models, have made some headway 53 , 54 , 59 .…”

Section: Discussionmentioning

confidence: 99%

Occipital Intralobar fasciculi: a description, through tractography, of three forgotten tracts

et al. 2021

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Diffusion MRI paired with tractography has facilitated a non-invasive exploration of many association, projection, and commissural fiber tracts. However, there is still a scarcity of research studies related to intralobar association fibers. The Dejerines’ (two of the most notable neurologists of 19th century France) gave an in-depth description of the intralobar fibers of the occipital lobe. Unfortunately, their exquisite work has since been sparsely cited in the modern literature. This work gives a modern description of many of the occipital intralobar lobe fibers described by the Dejerines. We perform a virtual dissection and reconstruct the tracts using diffusion MRI tractography. The dissection is guided by the Dejerines’ treatise, Anatomie des Centres Nerveux. As an accompaniment to this article, we provided a French-to-English translation of the treatise portion concerning five intra-occipital tracts, namely: the stratum calcarinum, the stratum proprium cunei, the vertical occipital fasciculus of Wernicke, the transverse fasciculus of the cuneus and the transverse fasciculus of the lingual lobule of Vialet. It was possible to reconstruct all but one of these tracts. For completeness, the recently described sledge runner fasciculus, although not one of the Dejerines’ tracts, was identified and successfully reconstructed.

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Anatomy of nerve fiber bundles at micrometer-resolution in the vervet monkey visual system

Cited by 27 publications

References 160 publications

Receptor architecture of macaque and human early visual areas: not equal, but comparable

Receptor architecture of macaque and human early visual areas: not equal, but comparable

Post mortem mapping of connectional anatomy for the validation of diffusion MRI

Occipital Intralobar fasciculi: a description, through tractography, of three forgotten tracts

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