Anatomy of the hepatic arteries and their extrahepatic branches in the human liver: A cadaveric study

Garg, Shweta; Kumar, Ketan; Sahni, Daisy; Yadav, Thakur Deen; Aggarwal, Anjali; Gupta, Tulika

doi:10.1016/j.aanat.2019.07.010

Cited by 12 publications

(7 citation statements)

References 25 publications

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“…The liver receives blood from the hepatic artery and portal vein and has a rich blood supply [ 25 ]. Therefore, the liver will be exposed to intestinal-derived microorganisms and food-derived harmless antigens at a high level for a long time, giving the liver a unique immune privilege [ 7 ].…”

Section: Discussionmentioning

confidence: 99%

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

et al. 2022

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Background The combined application of immune cells and specific biomarkers related to the tumor immune microenvironment has a better predictive value for the prognosis of HCC. The purpose of this study is to construct a new prognostic model based on immune-related genes that regulate cross-talk between immune and tumor cells to assess the prognosis and explore possible mechanisms. Method The immune cell abundance ratio of 424 cases in the TCGA-LIHC database is obtained through the CIBERSORT algorithm. The differential gene analysis and cox regression analysis is used to screen IRGs. In addition, the function of IRGs was preliminarily explored through the co-culture of M2 macrophages and HCC cell lines. The clinical validation, nomogram establishment and performing tumor microenvironment score were validated. Results We identified 4 immune cells and 9 hub genes related to the prognosis. Further, we identified S100A9, CD79B, TNFRSF11B as an IRGs signature, which is verified in the ICGC and GSE76427 database. Importantly, IRGs signature is closely related to the prognosis, tumor microenvironment score, clinical characteristics and immunotherapy, and nomogram combined with clinical characteristics is more conducive to clinical promotion. In addition, after co-culture with M2 macrophages, the migration capacity and cell pseudopod of MHCC97H increased significantly. And CD79B and TNFRSF11B were significantly down-regulated in MHCC97H, Huh7 and LM3, while S100A9 was up-regulated. Conclusion We constructed an IRGs signature and discussed possible mechanisms. The nomogram established based on IRGs can accurately predict the prognosis of HCC patients. These findings may provide a suitable therapeutic target for HCC.

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Section: Discussionmentioning

confidence: 99%

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

et al. 2022

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“…Blood flows from the abdominal aorta to a branch called the celiac artery. This artery is divided into the left gastric, splenic and hepatic arteries [21]. The hepatic artery delivers 25% of the incoming blood to the liver.…”

Section: Discussionmentioning

confidence: 99%

Comparative Anatomical Study Between the Human and Swine Liver and Its Importance in Xenotransplantation

Ntonas¹,

Katsourakis²,

Galanis³

et al. 2020

Cureus

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The liver is a multifunctional organ; due to its functional and structural complexity, there are many factors that may lead it to function inadequately, a state called liver failure. Transplantation is the only appropriate therapy for patients in cases of liver failure. However, there are many limitations to this treatment, and the scientific community has considered methods based on pigs because of their unique structural and cellular compatibility with humans. In this review, we conducted an anatomic comparative study of the liver's parenchyma and vascular network between humans and pigs to extract useful information for xenotransplantation and autologous cell or organ generation in pigs. We reviewed articles from 2007 to 2019 and used the databases of Scopus, PubMed and Google Scholar. We concluded that, despite the difference concerning the shape of the human and pig livers, the number of segments and the bile and vascular system are similar, making the pig liver useful in experimental surgery for xenotransplantation.

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“…(37) In the most dominant anatomical pattern the common hepatic artery (CHA) originates from the coeliac trunk (CT). (19) Past the branch-off point, CHA runs forwards and laterally, reaching the superior surface of the duodenum. (45)Then it divides into the gastroduodenal artery (GDA) and the proper hepatic artery (PHA).…”

Section: Introductionmentioning

confidence: 99%

“…(45)This vessel divides into the left hepatic artery (LHA) and the right hepatic artery (RHA). (19)They supply the right and left lobes of the liver, respectively. (2) The liver is the largest internal organ in the human body.…”

Section: Introductionmentioning

confidence: 99%

Assessment of the incidence of accessory hepatic arteries: a literature review

et al. 2022

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Anatomy of the hepatic arteries and their extrahepatic branches in the human liver: A cadaveric study

Cited by 12 publications

References 25 publications

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

A new nomogram model for prognosis of hepatocellular carcinoma based on novel gene signature that regulates cross-talk between immune and tumor cells

Comparative Anatomical Study Between the Human and Swine Liver and Its Importance in Xenotransplantation

Assessment of the incidence of accessory hepatic arteries: a literature review

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