ANCA-associated vasculitis of the appendix

Leaver, Phillip J; Jang, Helena Sung-In; Soh, Hwei-Choo; Fernando, Suran L.

doi:10.1093/rap/rkz037

Cited by 1 publication

(3 citation statements)

References 10 publications

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“…Clinical findings of this syndrome are similar to that of Kawasaki's disease, with sudden fever-most of the time of unknown origin-and multisystem inflammation including heart, lungs, kidneys, liver, skin, eyes, brain, and the GI tracts [3,5,[12][13][14]. As of now, GI involvement appears to be the predominate pattern in MIS-C and seen in 92% of patients [9].…”

Section: Discussionsupporting

confidence: 56%

“…In general, vasculitis involving the gastrointestinal tract is most commonly associated with medium-vessel vasculitis, such as polyarteritis nodosa, and usually occurs as part of the systemic vasculitis process [5]. In children, vasculitis in the appendix is mainly associated with other systemic diseases such as systemic lupus erythematosus (SLE) or other autoimmune diseases [1].…”

Section: Discussionmentioning

confidence: 99%

“…Approximately 75% of patients show bilateral lung infiltrates on chest X-ray and eventually developing what is called a COVID pneumonia [5].…”

Section: Hammad Et Almentioning

confidence: 99%

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Microvascular injury in the appendix of a pediatric patient with history of COVID-19 infection: A case report

Maryam¹,

Ashok²

2021

Case Rep Int

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Introduction: A novel coronavirus (SARS-CoV-2) infection has emerged in the world causing a pandemic disease with severe forms of acute respiratory failure along with other organs manifestations. Besides, frequent association with multisystem inflammatory syndrome in children (MIS-C) as complication after the recovery has been recorded. Hereby we report the histological findings in the appendix of a female pediatric patient with history of COVID-19 infection.Case Report: In our case, an 8-year-old female patient presented to the emergency department of our main tertiary hospital in Bahrain with two days history of low grade fever, lower abdominal pain, nausea, and vomiting. She was admitted to the pediatric surgical unit for a suspected acute appendicitis. A diagnostic laparoscopy and laparoscopic appendectomy was performed. The appendix was sent to the histopathology examination which confirmed the diagnosis of acute suppurative appendicitis with focal endarteritis obliterans. Retrospectively history revealed the child was COVID-19 positive three months back. Conclusion:Microvascular injury in the appendix of our case adds to the preliminary available evidences in the literature indicating that endarteritis obliterans of the gastrointestinal (GI) tract organs could be a complication of the COVID-19 virus infection like in MIS-C which is a known post-infectious complication of the virus.

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