Ancestry and dental development: A geographic and genetic perspective

Dhamo, Brunilda; Kragt, Lea; Grgić, Olja; Vučić, Strahinja; Medina‐Gomez, Carolina; Rivadeneira, Fernando; Jaddoe, Vincent W. V.; Wolvius, Eppo B.; Ongkosuwito, Edwin M.

doi:10.1002/ajpa.23351

Cited by 29 publications

(20 citation statements)

References 39 publications

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“…Across traits, several significant positive correlations were observed, with the strongest occurring between SS and DS, in both upper and lower incisors. Possible explanations for these correlations include admixture linkage disequilibrium (particularly for traits present with high frequencies in parental populations) and pleiotropic effects of certain genetic variants influencing dental development (Dhamo et al, ; Hillson, ; Hughes & Townsend, ; Townsend, Hughes, Luciano, Bockmann, & Brook, ).…”

Section: Resultsmentioning

confidence: 99%

“…Furthermore, the biodistance analysis and the average estimates of ancestry in the Colombian sample obtained from dental morphological data are consistent with the genetic estimates of ancestry: a predominant European ancestry, with substantial Native American ancestry and a relatively small African contribution. The correlation of certain dental features with specific genetic ancestries suggests that aspects of tooth morphology are likely to be influenced by alleles differentiated in frequency between continental populations (see Hubbard, Guatelli‐Steinberg, & Irish, ; Rathmann et al, ), probably involving loci impacting on tooth development (Dhamo et al, ; Edgar & Ousley, ). The three traits correlated with African ancestry detected here (C5UM2, CNLM1, and C7LM1) have been reported to show markedly higher frequencies in Sub‐Saharan Africans relative to other continental populations (Irish, , ; Scott & Irish, ; Scott & Turner, ).…”

Section: Discussionmentioning

confidence: 98%

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Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Delgado

Ramírez

Adhikari

et al. 2018

American J Phys Anthropol

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Objectives: To investigate the variation in dental nonmetric traits and to evaluate the utility of this variation for inferring genetic ancestry proportions in a sample of admixed Latin Americans. Materials and Methods:We characterized a sample from Colombia (N = 477) for 34 dental traits and obtained estimates of individual Native American, European, and African ancestry using genome-wide SNP data. We tested for correlation between dental traits, genetic ancestry, age, and sex. We carried out a biodistance analysis between the Colombian sample and reference continental population samples using the mean measure of divergence statistic calculated from dental trait frequencies. We evaluated the inference of genetic ancestry from dental traits using a regression approach (with 10-fold cross-validation) as well as by testing the correlation between estimates of ancestry obtained from genetic and dental data. Results: Latin Americans show intermediate dental trait frequencies when compared to NativeAmericans, Europeans, and Africans. Significant correlations were observed for several dental traits, genetic ancestry, age, and sex. The biodistance analysis displayed a closer relationship of Colombians to Europeans than to Native Americans and Africans. Mean ancestry estimates obtained from the dental data are similar to the genetic estimates (Native American: 32% vs. 28%, European: 59% vs. 63%, and African: 9% vs. 9%, respectively). However, dental features

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 98%

Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Delgado

Ramírez

Adhikari

et al. 2018

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…Ancestral genetics and geographical factors were purported to play a part in odontogenic development and maturity in populations with different races. Those of Caucasian descent were reported to have lower odontogenic potential and slower tooth development 48 , 49 . In contrast, the London Atlas showed no difference in dental maturity between British children of Caucasian origin and British children of Bangladeshi origin, and no differences in children from eight countries 50 – 52 .…”

Section: Discussionmentioning

confidence: 99%

Deep orofacial phenotyping of population-based infants with isolated cleft lip and isolated cleft palate

Yow

Hermann

Yuan

et al. 2020

Sci Rep

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Isolated orofacial clefts (OFC) are common with poorly understood aetiology. Heterogeneous phenotypes and subphenotypes confound aetiological variant findings. To improve OFC phenome understanding, population-based, consecutive, pre-treatment infants with isolated unilateral cleft lip (UCL, n = 183) and isolated cleft palate (CP, n = 83) of similar ancestry were grouped for deep phenotyping. Subphenotypes stratified by gender and cleft severity were evaluated for primary dental malformations and maturation using radiographs. We found that cleft severity and tooth agenesis were inadequate to distinguish heterogeneity in infants with UCL and CP. Both groups featured slow dental maturity, significantly slower in males and the UCL phenotype. In 32.8% of infants with UCL, supernumerary maxillary lateral incisors were present on the cleft lip side, but not in infants with CP, suggesting a cleft dental epithelium and forme fruste cleft dentoalveolus of the UCL subphenotype. The findings underscored the importance of deep phenotyping to disclose occult OFC subphenotypes.

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“…The ICC for the scored teeth ranged between 0.65 and 0.80, which is considered to be ‘substantial’ agreement according to the conventional criteria. 29 , 33 Central incisors were not taken into account due to the absence of variation in the stage of tooth development fitting with age of the children.…”

Section: Methodsmentioning

confidence: 99%

The association of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development

Dhamo

Jaddoe

Steegers

et al. 2021

Comm Dent Oral Epid

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Objective Low folic acid, folate and vitamin B12 might affect tooth formation and mineralization. The conversion of folic acid into folate is catalysed by the methylenetetrahydrofolate (MTHFR) enzyme which is encoded by the MTHFR gene. Among 3728 mothers and their 10‐year‐old children from the Generation R Study, we investigated associations of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development. Secondly, we checked the modifying effect of MTHFR‐C677T polymorphism. Methods Information on folic acid supplementation was obtained by questionnaires. Concentrations of folate and vitamin B12 were measured from venous samples taken in early pregnancy. Developmental stages of teeth were defined by the Demirjian method at the age‐10 assessment. In addition, dental age of the children was calculated using the Dutch standard. GLM and multivariate linear regression models were built to study the associations. Results Folic acid supplementation started when pregnancy was known (β = −0.09; 95% CI: −0.17, −0.01) and folic acid supplementation started prior to known pregnancy (β = −0.12; 95% CI: −0.20, −0.04) were both associated with decelerated dental development by 1‐2 months lower dental age of 10‐year‐old children. Folate (β = −0.02, 95% CI: −0.05, 0.02) and vitamin B12 (β = 0.03, 95% CI: −0.00, 0.06) were not associated with dental age. MTHFR‐C677T did not modify the associations. Conclusions Maternal folic acid supplementation delays dental development of children by 1‐2 months dental age, whereas maternal folate and vitamin B12 concentrations in early pregnancy do not affect the timing of child dental development.

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Ancestry and dental development: A geographic and genetic perspective

Cited by 29 publications

References 39 publications

Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Variation in dental morphology and inference of continental ancestry in admixed Latin Americans

Deep orofacial phenotyping of population-based infants with isolated cleft lip and isolated cleft palate

The association of maternal folic acid supplementation and prenatal folate and vitamin B12 concentrations with child dental development

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