In this work, a highly efficient
multifunctional non-enzymatic
electrochemical sensor is successfully fabricated based on a facile
two-step synthetic strategy. It resolves two important challenges
of poor stability and low reproducibility compared to conventional
electrochemical enzyme-based sensors. Herein, a metal–organic
framework (UiO-66) is selected as a sacrificial template to construct
the corresponding Prussian blue analogue (PBA) target to improve its
stability and conductivity, namely, PBA/UiO-66/NF. Target PBA/UiO-66/NF
exhibits excellent electrochemical sensing performance as hydrogen
peroxide (H2O2) and glucose sensors with ultrahigh
sensitivity of up to 1903 μA mM–1 cm–2 for H2O2 and 22,800 μA mM–1 cm–2 for glucose, as well as a very low detection
limit of 0.02 μM (S/N = 3) for H2O2 and
0.28 μM for glucose. Especially, extremely high stability can
be observed, which will be beneficial for practical application.