Ancient common ancestry of Crimean-Congo hemorrhagic fever virus

Carroll, Serena A.; Bird, Brian H.; Rollin, Pierre E.; Nichol, Stuart T.

doi:10.1016/j.ympev.2010.01.006

Cited by 81 publications

(74 citation statements)

References 42 publications

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“…This analysis indicates that the segment has evolved more slowly, and shows a correspondingly longer time to the most recent common ancestor, than the S-and Msegments (Carroll et al, 2010). Such reduced variation presumably reflects essential requirements for the efficient function of the RdRp.…”

Section: Genetic Driftmentioning

confidence: 94%

“…The articles from which the data were obtained are listed in Supplementary Table 1. To designate the lineages/clades of viruses isolated in various countries, we utilize both the Roman numeral system of Carroll et al (2010) and the geographic naming system of Hewson and co-workers (Atkinson et al, 2012b) ( Table 7).…”

Section: Geographic Range Of Cchfvmentioning

confidence: 99%

“…Within each of the trees, we identified six separate viral lineages or clades originating from the same branch points, indicating that their members share a common ancestor. We have labeled these clades I-VI, using the system employed by some other investigators (Carroll et al, 2010). As shown in Table 7, other researchers have identified 7, rather than 6 virus lineages, and have utilized a different labeling system.…”

Section: Genetic Diversity Of Cchfvmentioning

confidence: 99%

“…Three research groups have used sequence data to estimate the rate at which CCHFV is evolving over time (Anagnostou and Papa, 2009;Carroll et al, 2010;Chen, 2012). Both found that the three genome segments undergo roughly 10 À4 changes per nucleotide per year, or about two base changes per year for the entire genome.…”

Section: Genetic Driftmentioning

confidence: 99%

“…scenario, based on the recent finding that the CCHFV S and the M segments both originated approximately 3000-3500 years ago (Carroll et al, 2010). Interestingly, the investigators found that currently existing L segments pre-dated them, sharing a common ancestor some 7000 years before the present.…”

Section: Evidence Of Long-distance Virus Transportmentioning

confidence: 99%

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Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Bente, Dennis A.; Forrester, Naomi L.; Watts, Douglas M.; McAuley, Alexander J.; Whitehouse, Chris A.; and Bray, Mike, "CrimeanCongo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity" (2013 b s t r a c tCrimean-Congo hemorrhagic fever (CCHF) is the most important tick-borne viral disease of humans, causing sporadic cases or outbreaks of severe illness across a huge geographic area, from western China to the Middle East and southeastern Europe and throughout most of Africa. CCHFV is maintained in vertical and horizontal transmission cycles involving ixodid ticks and a variety of wild and domestic vertebrates, which do not show signs of illness. The virus circulates in a number of tick genera, but Hyalomma ticks are the principal source of human infection, probably because both immature and adult forms actively seek hosts for the blood meals required at each stage of maturation. CCHF occurs most frequently among agricultural workers following the bite of an infected tick, and to a lesser extent among slaughterhouse workers exposed to the blood and tissues of infected livestock and medical personnel through contact with the body fluids of infected patients. CCHFV is the most genetically diverse of the arboviruses, with nucleotide sequence differences among isolates ranging from 20% for the viral S segment to 31% for the M segment. Viruses with diverse sequences can be found within the same geographic area, while closely related viruses have been isolated in far distant regions, suggesting that widespread dispersion of CCHFV has occurred at times in the past, possibly by ticks carried on migratory birds or through the international livestock trade. Reassortment among genome segments during co-infection of ticks or vertebrates appears to have played an important role in generating diversity, and represents a potential future source of novel viruses. In this article, we first review current knowledge of CCHFV, summarizing its molecular biology, maintenance and transmission, epidemiology and geographic range. We also include an extensive discussion of CCHFV genetic diversity, including maps of the range of the virus with superimposed phylogenetic trees. We then review the features of CCHF, including the clinical syndrome, diagnosis, treatment, pathogenesis, vaccine development and laboratory animal models of CCHF. The paper ends with a discussion of the possible future geographic range of the virus. For the benefit of researchers, we include a Supplementary Table listing all published reports of CCHF cases and outbreaks in the English-language literature, plus some principal articles in other languages, with total case numbers, case fatality rates and all CCHFV strains on GenBank.

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Section: Genetic Driftmentioning

confidence: 94%

Section: Geographic Range Of Cchfvmentioning

confidence: 99%

Section: Genetic Diversity Of Cchfvmentioning

confidence: 99%

Section: Genetic Driftmentioning

confidence: 99%

Section: Evidence Of Long-distance Virus Transportmentioning

confidence: 99%

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Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

et al. 2013

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Whole‐genome sequencing of Crimean−Congo hemorrhagic fever virus circulating in Pakistan during 2022

Umair

Rehman

Haider

et al. 2023

Journal of Medical Virology

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Pakistan is an endemic country for Crimean−Congo hemorrhagic fever (CCHF) and its Balochistan province is considered a hotspot region for circulation of the virus whereas sporadic cases have been reported from other parts of the country. Our study aims to investigate the genomic diversity of the CCHF virus circulating in Punjab and Khyber Pakhtunkhwa provinces of Pakistan. Between April to September 2022, 46 samples from suspected CCHF patients were tested, with 6 (13%) showing positive RT-PCR results. Among the positive cases, all were male, aged 14−48 years among which 4 were butchers. Three CCHF patients succumbed to the disease. The complete S-M-L-gene fragments of 4 positive samples were sequenced. The S and L segments belonged to the Asia-1 clade and clustered with regional strains from Iran, India, and Afghanistan. One M segment sequence grouped into Africa-2 along with those reported from India during 2016−2019. We report the detection of a reassorted virus (NIH-PAK-CCHF-03|2022) having Asia-1-Africa-2-Asia-1 (S-M-L) segment pattern for the first time from Pakistan. Mutational analysis showed M segments harboring eight mutations (T55A,

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A Brief Historical Overview of the Discovery of Arboviruses in the USSR and Russia

Lvov,

Alkhovsky

2023

History of Arbovirology: Memories From the Field

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Ancient common ancestry of Crimean-Congo hemorrhagic fever virus

Cited by 81 publications

References 42 publications

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Crimean-Congo hemorrhagic fever: History, epidemiology, pathogenesis, clinical syndrome and genetic diversity

Whole‐genome sequencing of Crimean−Congo hemorrhagic fever virus circulating in Pakistan during 2022

A Brief Historical Overview of the Discovery of Arboviruses in the USSR and Russia

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