Ancient linkage of a POU class 6 and an anterior hox‐like gene in cnidaria: implications for the evolution of homeobox genes

Kamm, Kai; Schierwater, Bernd

doi:10.1002/jez.b.21196

Cited by 6 publications

(11 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the current assembly of the Trichoplax genome it is evident that the genes of the homeobox classes ANTP, PRD, LIM, TALE and Hnf are reciprocally linked. This supports the view that at least the founders of most metazoan homeobox classes have been ancestrally clustered (cf [21], [22]…”

Section: Supporting Informationsupporting

confidence: 85%

“…Comparison of the linkage patterns in sponges [16], cnidarians [11], [13], [15] and bilaterians [4], [7], [8], [10] suggests that most or all ANTP gene families have emerged from a single ancestral region and the remnants of linkage in Trichoplax conform to this scenario (Figure 1). Moreover, many of the remaining homeobox classes (Table 1) are reciprocally linked in the Trichoplax genome (Figure S3, Table S1), suggesting also ancient linkage of the predecessors of all metazoan homeobox classes (cf [21], [22]…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

et al. 2008

Self Cite

View full text Add to dashboard Cite

The evolution of ANTP genes in the Metazoa has been the subject of conflicting hypotheses derived from full or partial gene sequences and genomic organization in higher animals. Whole genome sequences have recently filled in some crucial gaps for the basal metazoan phyla Cnidaria and Porifera. Here we analyze the complete genome of Trichoplax adhaerens, representing the basal metazoan phylum Placozoa, for its set of ANTP class genes. The Trichoplax genome encodes representatives of Hox/ParaHox-like, NKL, and extended Hox genes. This repertoire possibly mirrors the condition of a hypothetical cnidarian-bilaterian ancestor. The evolution of the cnidarian and bilaterian ANTP gene repertoires can be deduced by a limited number of cis-duplications of NKL and “extended Hox” genes and the presence of a single ancestral “ProtoHox” gene.

show abstract

Section: Supporting Informationsupporting

confidence: 85%

Section: Resultsmentioning

confidence: 99%

The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

et al. 2008

Self Cite

View full text Add to dashboard Cite

show abstract

“…There are additional examples found in non-bilaterian lineages, such as clustering of a POU-class and ANTP-class gene in a cnidarian (Kamm and Schierwater, 2007). Also, a number of intriguing instances of homeobox clustering involving different gene classes are found in the placozoan Trichoplax adhaerens (Schierwater et al, 2008).…”

Section: The Antp-class Mega-homeobox Cluster Within a Homeobox Supermentioning

confidence: 99%

Evolution of Homeobox Gene Clusters in Animals: The Giga-Cluster and Primary vs. Secondary Clustering

Ferrier

2016

Front. Ecol. Evol.

View full text Add to dashboard Cite

The Hox gene cluster has been a major focus in evolutionary developmental biology. This is because of its key role in patterning animal development and widespread examples of changes in Hox genes being linked to the evolution of animal body plans and morphologies. Also, the distinctive organization of the Hox genes into genomic clusters in which the order of the genes along the chromosome corresponds to the order of their activity along the embryo, or during a developmental process, has been a further source of great interest. This is known as collinearity, and it provides a clear link between genome organization and the regulation of genes during development, with distinctive changes marking evolutionary transitions. The Hox genes are not alone, however. The homeobox genes are a large super-class, of which the Hox genes are only a small subset, and an ever-increasing number of further gene clusters besides the Hox are being discovered. This is of great interest because of the potential for such gene clusters to help understand major evolutionary transitions, both in terms of changes to development and morphology as well as evolution of genome organization. However, there is uncertainty in our understanding of homeobox gene cluster evolution at present. This relates to our still rudimentary understanding of the dynamics of genome rearrangements and evolution over the evolutionary timescales being considered when we compare lineages from across the animal kingdom. A major goal is to deduce whether particular instances of clustering are primary (conserved from ancient ancestral clusters) or secondary (reassortment of genes into clusters in lineage-specific fashion). The following summary of the various instances of homeobox gene clusters in animals, and the hypotheses about their evolution, provides a framework for the future resolution of this uncertainty.

show abstract

“…POU genes have only been recovered from Metazoa, suggesting that the POU S domain represents an animal novelty that was incorporated into a more ancient homeodomain containing gene during the early evolution of animals ( Degnan et al 2009 ). However, the presence of multiple, and often nonoverlapping, POU families in early-branching animal lineages makes rooting the POU gene tree difficult, and has led to conflicting topologies in gene tree reconstruction ( Kamm and Schierwater 2007 ; Larroux et al 2008 ; Ryan et al 2010 ).…”

Section: Introductionmentioning

confidence: 99%

The Early Expansion and Evolutionary Dynamics of POU Class Genes

Gold

Gates

Jacobs

2014

Molecular Biology and Evolution

View full text Add to dashboard Cite

The POU genes represent a diverse class of animal-specific transcription factors that play important roles in neurogenesis, pluripotency, and cell-type specification. Although previous attempts have been made to reconstruct the evolution of the POU class, these studies have been limited by a small number of representative taxa, and a lack of sequences from basally branching organisms. In this study, we performed comparative analyses on available genomes and sequences recovered through “gene fishing” to better resolve the topology of the POU gene tree. We then used ancestral state reconstruction to map the most likely changes in amino acid evolution for the conserved domains. Our work suggests that four of the six POU families evolved before the last common ancestor of living animals—doubling previous estimates—and were followed by extensive clade-specific gene loss. Amino acid changes are distributed unequally across the gene tree, consistent with a neofunctionalization model of protein evolution. We consider our results in the context of early animal evolution, and the role of POU5 genes in maintaining stem cell pluripotency.

show abstract

Ancient linkage of a POU class 6 and an anterior hox‐like gene in cnidaria: implications for the evolution of homeobox genes

Cited by 6 publications

References 37 publications

The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

The Early ANTP Gene Repertoire: Insights from the Placozoan Genome

Evolution of Homeobox Gene Clusters in Animals: The Giga-Cluster and Primary vs. Secondary Clustering

The Early Expansion and Evolutionary Dynamics of POU Class Genes

Contact Info

Product

Resources

About