2010
DOI: 10.1073/pnas.1002257107
|View full text |Cite
|
Sign up to set email alerts
|

Ancient origin of the integrin-mediated adhesion and signaling machinery

Abstract: The evolution of animals (metazoans) from their unicellular ancestors required the emergence of novel mechanisms for cell adhesion and cell-cell communication. One of the most important cell adhesion mechanisms for metazoan development is integrinmediated adhesion and signaling. The integrin adhesion complex mediates critical interactions between cells and the extracellular matrix, modulating several aspects of cell physiology. To date this machinery has been considered strictly metazoan specific. Here we repo… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

10
280
2

Year Published

2010
2010
2021
2021

Publication Types

Select...
5
4

Relationship

1
8

Authors

Journals

citations
Cited by 229 publications
(292 citation statements)
references
References 66 publications
10
280
2
Order By: Relevance
“…For instance, centrioles and cilia are entirely missing in Filasteria and Nucleariida, which use actin-based filopodia to crawl along a substrate (figure 1) [45,51,52,55,56,63]. A possible scenario is that the last common ancestor of all Amorphea or even of all eukaryotes was capable of both flagellar and actin-based motility, and different lineages lost one or the other (or both) while adapting to their specific environment [26,27,[64][65][66]. It is thus necessary when attempting to reconstitute the evolutionary history of the microtubule cytoskeleton to consider these aspects as well.…”
Section: Evolution Of Cytoskeleton Architecture In Amorpheamentioning
confidence: 99%
“…For instance, centrioles and cilia are entirely missing in Filasteria and Nucleariida, which use actin-based filopodia to crawl along a substrate (figure 1) [45,51,52,55,56,63]. A possible scenario is that the last common ancestor of all Amorphea or even of all eukaryotes was capable of both flagellar and actin-based motility, and different lineages lost one or the other (or both) while adapting to their specific environment [26,27,[64][65][66]. It is thus necessary when attempting to reconstitute the evolutionary history of the microtubule cytoskeleton to consider these aspects as well.…”
Section: Evolution Of Cytoskeleton Architecture In Amorpheamentioning
confidence: 99%
“…UNICORN is obtaining the genome sequence of several holozoans and holomycots, with the aim to better understand the origins of both fungi and animals. A first look at what this data can show us is provided by the analysis of the integrin-mediated signalling and adhesion machinery that conclusively shows that choanoflagellates (and fungi) have suffered some lineage-specific gene losses of this important machinery (Sebe´-Pedro´s et al, 2010). This should be taken as a cautionary tale, because gene loss is undoubtedly an important, and sometimes neglected, player in evolutionary history and that broad taxonomic sampling is critical in comparative genomic analyses.…”
Section: Opisthokonts An Evolutionary Window To Understanding the Unmentioning
confidence: 99%
“…To further explore the origin of the Ca 2+ signaling machinery, we have more recently reported the examination of several genomes at the Origins of Multicellularity Database [14,15], the Broad Institute and the NCBI genomic databases including the genomes of three basal fungi Allomyces macrogynus, Spizellomyces punctatus, and Batrachochytrium dendrobatidis [16]. Surprisingly, our analysis revealed the presence of P2X receptor homologs in the three basal fungi (AmaP2X, SpuP2X, and BdeP2X) ( Fig.…”
mentioning
confidence: 88%