Ancient schwannoma in oral cavity: a report of two cases

Abstract

(J Korean Assoc Oral Maxillofac Surg 2011;37:530-4) This paper reports two cases of schwannomas arising from the oral cavity. One is an intraoral ancient schwannoma located at the left cheek, which evolved over a period of 13 years. The tumor was a well-demarcated buccal mass, which was located in the left lower first premolar area, with an obliterated the buccal vestibule, leaving the overlying mucosa intact. The second case was a central intraosseous schwannoma located from the left lower 1st molar periapical area to the left 3rd molar periapical area. Pathologically, the first mass was composed of the spindle shaped tumor cells with wavy nuclei beneath the fibroconnective tissue of the gingiva but second case mass was not. Occasional nuclear pleomorphism was observed but mitosis or necrosis was absent. There were Antoni A and B areas along with strong, diffuse staining with the S-100 protein. Ancient schwannomas were diagnosed. Schwannoma is a slow-growing benign tumor, and an ancient schwannoma that shows cellular atypism is a variant of a schwannoma caused by purely degenerative changes. To date, only limited cases of ancient schwannomas in the oral cavity have been reported.

Ancient schwannoma of gingiva - A rare case report

“…[ 3 ] Oral AS is seen mostly in the tongue followed by buccal mucosa, labial mucosa, and palate; the present case was reported in the palatal surface of anterior maxillary gingiva. [ 3 4 ]…”

“…[ 2 ] Ancient schwannomas (ASs) are considered as long-standing variants of schwannoma, histologically characterized by hemorrhage, hemosiderin pigmentation, and pleomorphism of cells. [ 3 ] AS arising in oral cavity is exceedingly rare and only 18 cases have been reported in the literature as per our best knowledge. [ 4 ] An exhaustive review of literature could not reveal a single case of oral AS in a pediatric patient.…”

Giant paratracheal ancient schwannoma in 57-year-old male patient: case report

“…Cautious surgical treatment includes extra capsular "peeling" or even intra capsular enucleation of the tumor from its origin. This can avoid transitory or permanent neurological functional defects [12].…”

Histogenetic Concepts, Terminology and Categorization of Biphasic Tumours of the Oral and Maxillofacial Region

“…Microscopically, the tumour is characterized by the presence of two patterns which are called Antoni A and Antoni B [56]. The Antoni A pattern is demonstrated by streaming fascicles of spindle shaped cells.…”