We prove the following result: Let (M, g 0 ) be a compact manifold of dimension n ≥ 12 with positive isotropic curvature. Then M is diffeomorphic to a spherical space form, or a compact quotient of S n−1 × R by standard isometries, or a connected sum of a finite number of such manifolds. This extends recent work of Brendle, and implies a conjecture of Schoen in dimensions n ≥ 12. The proof uses Ricci flow with surgery on compact orbifolds with isolated singularities.