Ancillary treatment of patients with lung disease due to non-tuberculous mycobacteria: a narrative review

Youssefnia, Artmis; Pierre, Alicia; Hoder, Jeffrey; MacDonald, Michelle; Shaffer, Monica; Friedman, Jessica; Mehler, Philip S.; Bontempo, Amanda; Silva, Francisco C. N. da; Chan, Edward D.

doi:10.21037/jtd-22-410

Cited by 7 publications

(1 citation statement)

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“…Moreover, patients with pulmonary NTM infection will require life-long attention to their bronchiectasis, irrespective of the status of their NTM infection, namely cured, cleared or persistent [ 103 ]. Limited data are available on airway clearance techniques and pulmonary rehabilitation specifically for NTM-PD [ 104 , 105 ]. However, the application of current physiotherapy recommendations for bronchiectasis, including active cycle of breathing techniques, autogenic drainage and positive expiratory pressure devices, seems reasonable in NTM-PD patients to reduce the impact of cough, improve quality of life and reduce exacerbation risk [ 106 ].…”

Section: Treatment Of Ntm Infection In Bronchiectasismentioning

confidence: 99%

Growing from common ground: nontuberculous mycobacteria and bronchiectasis

Van Braeckel,

Bosteels

2024

Eur Respir Rev

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Bronchiectasis and nontuberculous mycobacteria (NTM) are intricately intertwined, with NTM capable of being both a cause and consequence of bronchiectatic disease. This narrative review focuses on the common ground of bronchiectasis and NTM pulmonary disease (NTM-PD) in terms of diagnostic approach, underlying risk factors and treatment strategies. NTM-PD diagnosis relies on a combination of clinical, radiological and microbiological criteria. Although their epidemiology is complicated by detection and reporting biases, the prevalence and pathogenicity of NTM species vary geographically, withMycobacterium aviumcomplex andMycobacterium abscessussubspecies most frequently isolated in bronchiectasis-associated NTM-PD. Diagnosis of nodular bronchiectatic NTM-PD should prompt investigation of host factors, including disorders of mucociliary clearance, connective tissue diseases and immunodeficiencies, either genetic or acquired. Treatment of NTM-PD in bronchiectasis involves a multidisciplinary approach and considers the (sub)species involved, disease severity and comorbidities. Current guideline-based antimicrobial treatment of NTM-PD is considered long, cumbersome and unsatisfying in terms of outcomes. Novel treatment regimens and strategies are being explored, including rifampicin-free regimens and inclusion of clofazimine and inhaled antibiotics. Host-directed therapies, such as immunomodulators and cytokine-based therapies, might enhance antimycobacterial immune responses. Optimising supportive care, as well as pathogen- and host-directed strategies, is crucial, highlighting the need for personalised approaches tailored to individual patient needs. Further research is warranted to elucidate the complex interplay between host and mycobacterial factors, informing more effective management strategies.

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