Ancrod reduces intracerebral hemorrhage quantified in vivo by magnetic resonance imaging in rats

Elger, Bernd; Hornberger, Wilfried; Schwarz, Margarete; Seega, Jürgen; Zahn, W.

doi:10.1016/s1052-3057(98)80016-5

Cited by 1 publication

(2 citation statements)

References 33 publications

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“…104 It has been trialled for ischemic stroke therapy with inconsistent outcomes, [105][106][107][108][109] attributed to the induced formation of fibrin and microvascular occlusion observed in vitro. 110 Elger et al 19 found a 50% reduction in ICH volume in rats treated with a low dose of ancrod instead of aggravating the bleed. Treatment started after collagenase injection, and effects were observed 24 h after injury; however, results were inconclusive about impact on levels of cerebral edema.…”

Section: Hematoma Clearancementioning

confidence: 97%

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Revisiting promising preclinical intracerebral hemorrhage studies to highlight repurposable drugs for translation

Crilly

Withers

Allan

et al. 2020

International Journal of Stroke

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Intracerebral hemorrhage is a devastating global health burden with limited treatment options and is responsible for 49% of 6.5 million annual stroke-related deaths comparable to ischemic stroke. Despite the impact of intracerebral hemorrhage, there are currently no effective treatments and so weaknesses in the translational pipeline must be addressed. There have been many preclinical studies in intracerebral hemorrhage models with positive outcomes for potential therapies in vivo, but beyond advancing the understanding of intracerebral hemorrhage pathology, there has been no translation toward successful clinical application. Multidisciplinary preclinical research, use of multiple models, and validation in human tissue are essential for effective translation. Repurposing of therapeutics for intracerebral hemorrhage may be the most promising strategy to help relieve the global health burden of intracerebral hemorrhage. Here, we have reviewed the existing literature to highlight repurposable drugs with successful outcomes in preclinical models of intracerebral hemorrhage that have realistic potential for development into the clinic for intracerebral hemorrhage.

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Section: Hematoma Clearancementioning

confidence: 97%

“…110 Elger et al. 19 found a 50% reduction in ICH volume in rats treated with a low dose of ancrod instead of aggravating the bleed. Treatment started after collagenase injection, and effects were observed 24 h after injury; however, results were inconclusive about impact on levels of cerebral edema.…”

Section: Introductionmentioning

confidence: 97%