Änderungen der TNM-Klassifikation gynäkologischer Tumoren

Abstract

Based on the results of clinical and histomorphological studies in recent years, a revision of the TNM classification of malignant tumours of the female genital organs became necessary. Vulvar cancer saw the most significant changes. In the T1 category the new system recognises tumour size and its relation to the infiltration of adjacent structures by the tumour. The number of positive regional lymph nodes has also been included in the new staging system. For cervical cancer, there is a new subdivision of the category T2a depending on tumour size with a breakpoint of ≤ 4 cm versus > 4 cm and a subdivision into T2a1 und T2a2. In endometrial cancer, the previous pT1a and pT1b were merged to pT1a. The former category T1c has changed into T1b. The category pT1c is no longer used. For the first time, there is a TNM classification system for uterine sarcomas.

Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: Emergence of new molecular targets

“…Thirty-eight endometrioid EnCa tumors were grouped according to the Tumor – (Lymph) Nodes – Metastasis (TNM) classification stages T1a to T3b and differentiation growth patterns G1 (differentiated) to G3 (undifferentiated). T1a represents tumor localisation to the endometrium; T1b endometrial localisation with over 50% myometrial growth, T2 demonstrates tumor infiltration into the stroma of cervix uteri; and T3 and T4 with distant metastasis [65]. According to the above classifications our EnCa cohort represented T1a/G1 (n=8), T1a/G2 (n=4), T1a/G3 (n=3), T1b/G1 (n= 3), T1b/G2 (n=5), T1b/G3 (n= 2), T2/G1 (n=4), T2/G2 (n=5), T2/G3 (n=2), T3a/G3(n=1) and T3b/G3 (n=1) (mean age: 67.71 +/− 1.73 yr).…”

Abstract 4800: Reactivation of codogenic endogenous retroviral (ERV) envelope genes in human endometrial carcinoma and prestages: emergence of new molecular targets.

“…Thirtyeight endometrioid EnCa tumors were grouped according to the Tumor -(Lymph) Nodes -Metastasis (TNM) classification stages T1a to T3b and differentiation growth patterns G1 (differentiated) to G3 (undifferentiated). T1a represents tumor localisation to the endometrium; T1b endometrial localisation with over 50% myometrial growth, T2 demonstrates tumor infiltration into the stroma of cervix uteri; and T3 and T4 with distant metastasis [65]. According to the above classifications our EnCa cohort represented T1a/G1 (n=8), T1a/G2 (n=4), T1a/G3 (n=3), T1b/G1 (n= 3), T1b/G2 (n=5), T1b/G3 (n= 2), T2/ G1 (n=4), T2/G2 (n=5), T2/G3 (n=2), T3a/G3(n=1) and T3b/G3 (n=1) (mean age: 67.71 +/-1.73 yr).…”