Andrew Fielding Huxley (1917–2012)

Huang, Christopher L.‐H.

doi:10.1113/jphysiol.2012.238923

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2014

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Huxley, Andrew Fielding

Huang

2014

Encyclopedia of Life Sciences

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Andrew Huxley (1917–2012) graduated in Natural Sciences at Cambridge (1935–1939), beginning research on nerve excitation with Alan Hodgkin in 1939. During World War II he worked on operational anti‐aircraft and naval gunnery. He returned to Cambridge in 1945, moved to University College London in 1960 and returned to Cambridge as Master of Trinity College (1984–1990). Huxley made major contributions on nerve conduction and muscle activation. He analysed nerve action potentials invoking underlying transmembrane ion movements, and their saltatory propagation in myelinated nerves. His muscle work demonstrated the action of the transverse tubules conveying surface excitation to the interior thereby initiating contraction. He established the sliding filament theory for actin–myosin interaction involving actions of cross‐bridges formed between them. Huxley was awarded the 1963 Nobel Prize in Physiology or Medicine with Hodgkin and John Eccles, elected to the Royal Society in 1955, knighted in 1974 and created Order of Merit in 1983.

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